DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and Stk33

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_473444.1	Gene:	Stk33 / 117229	MGIID:	2152419	Length:	491	Species:	Mus musculus

Alignment Length:	396	Identity:	125/396 - (31%)
Similarity:	203/396 - (51%)	Gaps:	69/396 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 SGIPVVRLS--------DFFGSDDVFFAYGTERINTAEDFKLEAEEQRAINVIRKTM----RTTG 417
            |.:.||.:|        :||.|.:......|.|.::.:|..:     |..||.||..    |:..
Mouse    32 SPVLVVEMSQTSSIGSTEFFASQERKKERNTSRESSLKDLSI-----RTSNVERKPQAQWSRSNV 91

  Fly   418 TTCKGPKPKMPIKSKKVYPPLVDSEPFKAETTPEDDRHAALLTSTGMEINELPSNIRNTYSLGRI 482
            |..|.|..:|                        ||         |..|.|.       |:.|||
Mouse    92 TVGKIPHIRM------------------------DD---------GAGIEEF-------YTFGRI 116

  Fly   483 IGDGNFAIVFKIKHRQTGHSYALKIIDKNKC-KGKEHYIDAEVRVMKKLNHPHIISLILSVDQNT 546
            :|.|:|.:||:...::||..:|:|.::|.|. ......::.||.::|.:||.|||.|....:...
Mouse   117 LGQGSFGMVFEAIDKETGAKWAIKKVNKEKAGSSAMKLLEREVSILKTVNHQHIIHLEQVFESPQ 181

  Fly   547 NMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKPENLLVK---L 608
            .||||:|....|:|...:.|...||||::|::|:.|.:|:.|||:..|||||:|.||::||   :
Mouse   182 KMYLVMELCEDGELKAVMDQRGHFSENETRLIIQSLASAIAYLHNKDIVHRDLKLENIMVKSSFI 246

  Fly   609 DEHGNV-LELKLADFGLACEVN-----DLLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYI 667
            |::..: |.:|:.||||:.:.:     .::...||||.|:|||::....|..:.|:|:.|:|::|
Mouse   247 DDNNEMNLNIKVTDFGLSVQKHGSRSEGMMQTTCGTPIYMAPEVINAHDYSQQCDIWSIGVIMFI 311

  Fly   668 LLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDH 732
            ||||.|||:|  |.:|.|::.|..|...|.:|.|..:.|..::.:..:::.||..|.|::::||:
Mouse   312 LLCGEPPFLA--NSEEKLYELIKKGELRFENPVWESVSDSAKNTLKQLMKVDPAHRITAKELLDN 374

  Fly   733 SWTIGN 738
            .|..||
Mouse   375 QWLTGN 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711
		DCX	308..396	CDD:214711	9/38 (24%)
		PKc_like	477..734	CDD:304357	97/266 (36%)
		S_TKc	477..734	CDD:214567	97/266 (36%)
Stk33	NP_473444.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..89		10/42 (24%)
		PKc_like	109..377	CDD:419665	98/276 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..491
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820