DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and Mylk

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	NP_647461.3	Gene:	Mylk / 107589	MGIID:	894806	Length:	1950	Species:	Mus musculus

Alignment Length:	880	Identity:	202/880 - (22%)
Similarity:	357/880 - (40%)	Gaps:	203/880 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EKVKINSLHCND--AVLSSLQASPSATSPQSVPSKANVVTEASII-EKTNQPHNVQEDNNYNR-- 63
            |:.|::|....|  :||:. :.:|....|:..|.||......|:: .|...|    .:|..|.
Mouse   938 EERKVHSPQQVDFRSVLAK-KGTPKTPVPEKAPPKAATPDFRSVLGGKKKSP----SENGGNSAE 997

  Fly    64 --DCDSPESSSSEQDKE----LDDLRNLHSSSLTNSVVVGKSTGSLNGVYSITSVTSETKTLESV 122
              :..:.||.:...|.:    |..:.|...:.....:...|.|.:|..|.:    |...:||:.:
Mouse   998 VLNVKAGESPTPAGDAQAIGALKPVGNAKPAETPKPIGNAKPTETLKPVGN----TKPAETLKPI 1058

  Fly   123 VTTNSASGSACLSNTPTADHIK-----KRIPSSRTPTRKALRIKFYRNGDRFYPGITIPVSNERY 182
            .....:.....::|...|:..|     |...:|: |..|. .:|..:|......|......||:.
Mouse  1059 ANAQPSGSLKPVTNAQPAEPQKPVGNAKSAETSK-PAGKE-EVKEVKNDVNCKKGQVGATGNEKR 1121

  Fly   183 RS-------FERLFEDL-----TRLLEENVKIPGAVRTI-YNLCGKKI----------------T 218
            ..       |:...:|:     .:||.:...|.....|: ::|.||.:                .
Mouse  1122 PESQGSAPVFKEKLQDVHVAEGEKLLLQCQVISDPPATVTWSLNGKTLKTTKFIVLAQEGSRFSV 1186

  Fly   219 SLDEL--ED------------GQSYVCSC--------NNENFKKVEYNTGSQPLSNL-PLSNSRS 260
            |:::.  ||            ||: .|||        .:||.|..|..: .:|.|:| |:..:.|
Mouse  1187 SIEKALPEDRGLYKCVAKNSAGQA-ECSCQVTVDDAQTSENTKAPEMKS-RRPKSSLPPVLGTES 1249

  Fly   261 NSHRLAKCRPSSPLKN------------------------GLLAGSSPFPAC------------- 288
            ::....|..|.:|.|.                        |.:||:.|. .|
Mouse  1250 DATVKKKPAPKTPTKAAMPPQIIQFPEDQKVRAGEPVELFGKVAGTQPI-TCKWMKFRKQIQESE 1313

  Fly   289 -----GGGTGNGSPLIASRLSDRVTVVHPRIVTLI---RSGTKPRRIMRLLLNKRNSPSFDHVLT 345
                 .|.:|:...::|:|..      |....||:   :.|::..::...:::|.:.|:.    |
Mouse  1314 HIKVENGESGSKLTILAARQE------HCGCYTLVVENKLGSRQAQVNLTVVDKPDPPAG----T 1368

  Fly   346 AITQVVRLDTGYVRKVFTLSGIPVVRLSDFFGS-------------------DDVFFAYGTERIN 391
            .....:|..:      .|||         ::||                   |.|:....|.|..
Mouse  1369 PCASDIRSSS------LTLS---------WYGSSYDGGSAVQSYNVEIWDTEDKVWKELATCRST 1418

  Fly   392 T--AEDFKLEAEEQ---RAINV--IRKTMRTTGTTCKGPKPKMPIKSKKVYPPLVDSEPFKAETT 449
            :  .:|...:.|.:   ||:||  ..:..:.:..|..|.||:.|....:|    .|.:    |..
Mouse  1419 SFNVQDLLPDREYKFRVRAVNVYGTSEPSQESELTAVGEKPEEPKDEVEV----SDDD----EKE 1475

  Fly   450 PEDDRHAALLTSTGMEINELPSNIRNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCK 514
            ||.| :..:..:|..:::::       |.:...:|.|.|..||::..::||..:|.|.......|
Mouse  1476 PEVD-YRTVTVNTEQKVSDV-------YDIEERLGSGKFGQVFRLVEKKTGKIWAGKFFKAYSAK 1532

  Fly   515 GKEHYIDAEVRVMKKLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFD-AITQVTRFSENQSRIM 578
            .|:: |..|:.:|..|:||.::..:.:.::..|:.:|||.||||:||: .|.:....:|.:....
Mouse  1533 EKDN-IRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKY 1596

  Fly   579 IRHLGAAMTYLHSMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLACEVNDL--LYAVCGTPTY 641
            :|.:...:.|:|..||||.|:||||::. :::.|.  .:||.|||||..:.:.  |..:.|||.:
Mouse  1597 MRQISEGVEYIHKQGIVHLDLKPENIMC-VNKTGT--RIKLIDFGLARRLENAGSLKVLFGTPEF 1658

  Fly   642 VAPEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGD 706
            ||||::.....|...|:|:.|:|.|||:.|..||:. ||..|.|.: :.|..::|.|..:.:|.|
Mouse  1659 VAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMG-DNDNETLAN-VTSATWDFDDEAFDEISD 1721

  Fly   707 GVRDLIANMLQADPDVRFTSEDILDHSWTIGNKGN 741
            ..:|.|:|:|:.|...|......|.|.|.:.:..|
Mouse  1722 DAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKN 1756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711	28/141 (20%)
		DCX	308..396	CDD:214711	17/111 (15%)
		PKc_like	477..734	CDD:304357	86/259 (33%)
		S_TKc	477..734	CDD:214567	86/259 (33%)
Mylk	NP_647461.3	I-set	42..132	CDD:254352
		Ig	42..131	CDD:299845
		I-set	165..254	CDD:254352
		Ig	183..251	CDD:143165
		23ISL	255..409	CDD:293226
		I-set	411..501	CDD:254352
		Ig	428..498	CDD:143165
		I-set	511..597	CDD:254352
		IGc2	524..587	CDD:197706
		I-set	620..709	CDD:254352
		Ig	637..706	CDD:143165
		I-set	718..806	CDD:254352
		Ig	721..806	CDD:299845
		I-set	1129..1218	CDD:254352	17/89 (19%)
		IGc2	1142..1208	CDD:197706	10/65 (15%)
		Ig	1269..1366	CDD:299845	14/103 (14%)
		I-set	1269..1358	CDD:254352	13/95 (14%)
		FN3	1362..1453	CDD:238020	18/109 (17%)
		STKc_MLCK1	1492..1750	CDD:271093	86/270 (32%)
		Pkinase	1495..1750	CDD:278497	86/260 (33%)
		I-set	1840..1930	CDD:254352
		IGc2	1853..1920	CDD:197706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010