DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17528 and dclk3

DIOPT Version :9

Sequence 1:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster
Sequence 2:	XP_017950468.2	Gene:	dclk3 / 100493379	XenbaseID:	XB-GENE-983282	Length:	793	Species:	Xenopus tropicalis

Alignment Length:	770	Identity:	216/770 - (28%)
Similarity:	313/770 - (40%)	Gaps:	276/770 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 LEDGQSYVCSCNNENFKKVEYNTGSQPL---SNL-PLSNSRSNSHRLAKCRPSSPLKNGLLAGSS 283
            |...:...||| .:|.      :|..||   |:: .:|.:....|::. |.|..|         .
Frog     6 LASSEYAACSC-KQNV------SGEHPLFGDSHINTISKTTDRRHQVT-CPPMGP---------R 53

  Fly   284 PFPACGGGTGN-GSPLIASR-----LSDRVTVVHPRIVTLIRSGTKPRRIMRLLLNKRNSPSFDH 342
            ||.....|..| .||.:.|:     :....:.|.|||||:::.|:.|.:.:.||||||:..:|:.
Frog    54 PFAKPFLGINNYTSPYLHSQNGFHTIHSENSPVKPRIVTVVKPGSHPLKKITLLLNKRSVQTFEQ 118

  Fly   343 VLTAITQVV---RLDTGYVRKVFTLSGIPVVRLSDFFGSDDVFFAYGTERINTA----------- 393
            ::..|::.:   |.....|||::.|.|..:..:||||..||:|.|.|.|::.|.
Frog   119 LVADISEALGFPRWKNDRVRKLYNLRGKEIRSISDFFRGDDIFIALGREKLTTKCTESVFNELYP 183

  Fly   394 ---------EDFKLEAE-EQRAINV---------------------IRKTMRTTGTTCKGPKPKM 427
                     :|.||... |.:.:::                     ..|..|.|...|:..:.|.
Frog   184 ERSAKKSKDQDGKLRCGLENKGLHIGNGNNDIDVAHNYEDSMSPRGATKFDRRTNNKCRAEETKR 248

  Fly   428 ------------------PIKS------------------------------KKVYP-------- 436
                              |||.                              :.:|.
Frog   249 IKQCDIEKCDREKFKCFGPIKRAELCCNKQNLMKCTSLSCIIRCDHCRVHKYRNIYNRDYEKDIS 313

  Fly   437 -------------------------PL--VDSEPF--------------KAETTPEDD---RHAA 457
                                     ||  :..|..              |.||...||   .:..
Frog   314 FEGSGTISLHGLHFNKEESKNCKKCPLENIQEEELRLKCKACNCKWKDTKRETIIGDDLINNNIE 378

  Fly   458 LLTSTGMEINELPS--------------------------------------------------- 471
            :...|..:.:.||.
Frog   379 MYEKTDWQESRLPKENLYRKELKKNQCRDVLDGFSVRKHLNGLLQNDSEEPKQSMSRLHGDNITI 443

  Fly   472 ----------------------------------------------------NIRNTYSLGRIIG 484
                                                                :|.:.|.:||.||
Frog   444 NNDYGNKKEKTKDPQILKTEAGPGGFPPKLRSDAKGNCLFTLKRPCCIKTSRDIESYYEIGRTIG 508

  Fly   485 DGNFAIVFKIKHRQTGHSYALKIIDKNKCKGKEHYIDAEVRVMKKLNHPHIISLILSVDQNTNMY 549
            |||||:|...:.......||:|||||:|.:|||..|:.|||::|.|:||:|:.|....:....:|
Frog   509 DGNFAVVKVCRPWNENQEYAMKIIDKSKLRGKEDIIENEVRIIKHLSHPNIVKLFSDYETEKEIY 573

  Fly   550 LVLEYVSGGDLFDAITQVTRFSENQSRIMIRHLGAAMTYLHSMGIVHRDIKPENLLVKLDEHGNV 614
            |:|||:.||||||.||:..:|:|:.:.:|:..|..|:.|:||..|||||:|||||||:.:..|:
Frog   574 LILEYIRGGDLFDVITESIKFTEHDAALMLIDLCEALKYIHSKHIVHRDLKPENLLVQHNPDGS- 637

  Fly   615 LELKLADFGLACEVNDLLYAVCGTPTYVAPEILLEVGYGLKIDVWAAGIILYILLCGFPPFVAPD 679
            ..|||||||||......::.|||||||||||||.|.|||||:|:||.|:||||||||||||.:||
Frog   638 KSLKLADFGLAIYATGPIFTVCGTPTYVAPEILSEKGYGLKVDMWATGVILYILLCGFPPFRSPD 702

  Fly   680 NQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANMLQADPDVRFTSEDILDHSW 734
            ..||.||..|.||.|||..|||..|.:.|:|||:.:|..:|::|::::.:|.|||
Frog   703 RNQEELFQIIQSGEYEFLPPYWDHISEEVKDLISKLLVLNPEIRYSAKCVLQHSW 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17528	NP_001036462.1	DCX	153..244	CDD:214711	5/20 (25%)
		DCX	308..396	CDD:214711	33/110 (30%)
		PKc_like	477..734	CDD:304357	135/256 (53%)
		S_TKc	477..734	CDD:214567	135/256 (53%)
dclk3	XP_017950468.2	DCX_DCLK3	87..171	CDD:340528	31/83 (37%)
dclk3	XP_017950468.2	STKc_DCKL3	500..757	CDD:271087	135/257 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D291886at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920