Protein Alignment conu and SRGAP3

DIOPT Version :9

• Sequence 1: NP_001036454.1
• Gene: conu / 3355133
• FlyBaseID: FBgn0039994
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: XP_016863063.1
• Gene: SRGAP3 / 9901
• HGNCID: 19744
• Length: 1117
• Species: Homo sapiens
• Alignment Length: 688
• Identity: 126/688 - (18%)
• Similarity: 231/688 - (33%)
• Gaps: 228/688 - (33%)

  Fly    57 KPFEQGLEVSKK------DLEPILTTLSKPHAEAI----------VQLVRTLNKT-----VRVRT 100
            |..|.||::.::      :|..::.|....|||:|          .|..:..||:     ..:|.
Human   159 KSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRH 223

  Fly   101 KSRPKRKPDIRDVFREFDEQGTVTRSRSATPDSLDSLQIDEAWTNNSLPTFVNVYEKNTETAIQC 165
            :.||:|:..::.:.:       :...|.|                           |.:|..::|
Human   224 EDRPQRRSSVKKIEK-------MKEKRQA---------------------------KYSENKLKC 254

  Fly   166 VEQSNEIYLKQNLRRTPSAPPKSGTY--ADI-------FRGSQVRCDIPLYSAD-GVELLGYSRI 220
            .:..|:..|  ||..|.:|..|...:  :|:       |..|..|......||: .:|...:..:
Human   255 TKARNDYLL--NLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGL 317

  Fly   221 GTIQFPRNRSVSDPFCSIGRSKESRSEN-DARSQKKKSSEVLSASENECGRLLPMPYNVLSFE-- 282
            ..|                   |:..:| |:||.|....::       |.::...|   |.||
Human   318 DVI-------------------ENAVDNLDSRSDKHTVMDM-------CNQVFCPP---LKFEFQ 353

  Fly   283 -----SICRDSS----------------------SLDSCEVLDTCDIPSTLFTDVVLI------- 313
                 .:|:.|:                      .:::.||..|.|.......|::.:
Human   354 PHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSD 418

  Fly   314 ---------------SETDMKRLQ-------------------------TILWLELATIFDRNKV 338
                           |||.|.::.                         :.|..:|....|..|.
Human   419 AFQHSRSTESVKSAASETYMSKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQ 483

  Fly   339 SLDK---------------RKPFKRRRKE-----EGNLFGVSINALIRRDQQVTGTDSSLVPLFL 383
            :|.:               .||.|.||..     ...||..|:.|.|:...|.       :||.:
Human   484 TLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQA-------IPLVV 541

  Fly   384 EKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWL 448
            |..|..:...|.:::|:.|:.|    :::..|:::::|.:..|.|.:......::.::.:||.:.
Human   542 ESCIRYINLYGLQQQGIFRVPG----SQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYF 602

  Fly   449 RELPQPLLTNELIQLFYQCHTLPS-IDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINK 512
            |.|..||...|..|.......|.: .::::.:..:...||......:|.|.:|.|.:....|.|.
Human   603 RGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENM 667

  Fly   513 MNVHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVES-- 575
            |:.:|:|....|::     :|..|..   :.|...|....:...:|:..|.:|..|..|  |.
Human   668 MDPYNLAICFGPTL-----MHIPDGQ---DPVSCQAHINEVIKTIIIHHEAIFPSPREL--EGPV 722

  Fly   576 -QKTMMGKKGWHRHRNSNEITAKPSGKASNVG-VGHDS 611
             :|.|.|         ..|....|..:...:. |.||:
Human   723 YEKCMAG---------GEEYCDSPHSEPGAIDEVDHDN 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	49/223 (22%)
SRGAP3	XP_016863063.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910