DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and Ophn1

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001300683.1	Gene:	Ophn1 / 94190	MGIID:	2151070	Length:	802	Species:	Mus musculus

Alignment Length:	726	Identity:	138/726 - (19%)
Similarity:	258/726 - (35%)	Gaps:	211/726 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DDQDFSEFLNEYY---LQSNSQSIEPEASYEDGEMEAEWLVSA--GYPELTKPFEQGLEVSKKDL 70
            |..||.:.| :||   |:..::.|:.  ..:||..    |:||  .|....:.|.|.|:..:.|.
Mouse    14 DSPDFRQRL-KYYEEELERTNKFIKD--VIKDGSA----LISAMRNYSSAVQKFSQTLQSFQFDF 71

  Fly    71 EPILTTLSKPH---AEAIVQLVRTLNKTVRVR-------------------------TKSRPKRK 107
              |..||:...   ||:..:....||:....|                         ||.|.|:.
Mouse    72 --IGDTLTDDEINIAESFKEFAELLNEVENERMMMVQNASDLLIKPLETFRKEQIGFTKERKKKF 134

  Fly   108 PDIRDVFREFDEQGTVTRSRSATPDSLDS-LQIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNE 171
            ....:.|....::.....|:......|:: ||:|:...|....:...||:      ||.|::|.:
Mouse   135 EKDGERFYSLLDRHLHLSSKKKESQLLEADLQVDKERHNFFESSLDYVYQ------IQEVQESKK 193

  Fly   172 IYLKQNLRRTPSAPPKSGTYADIFRGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFC 236
            ..:.:         |.......:|..:.:..::.      .:.|.|.:  .:|.....:
Mouse   194 FNIVE---------PVLAFLHSLFISNSLTVELT------QDFLPYKQ--QLQLSLQNT------ 235

  Fly   237 SIGRSKESRSENDARSQKKKSSEV-------------------------LSASENECG------- 269
               |:..|.:..:....||:..|.                         :|.::..|.
Mouse   236 ---RNHFSSTREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWAKYYCRYEKETRM 297

  Fly   270 -RLLPM---------PYNVLSFESICRDSSSLDS--CEVLDTCDIPSTLFTDVVLISETDMKRLQ 322
             .::||         |.::.....:.|.:.|:|.  |..::|.:.|.|    :.|.:.::..|.
Mouse   298 LTMIPMEQKPGAKQGPVDLTLKYCVRRKTESIDKRFCFDIETNERPGT----ITLQAPSEANRR- 357

  Fly   323 TILWLELATIFDRNKVSLDKRKPFKR---RRKEEGNLFGVSINALIRRDQQVTGTDSSLVPLFLE 384
              ||:|          ::|.::|...   .::||..|..|...                   |:.
Mouse   358 --LWME----------AMDGKEPIYHTPITKQEEMELNEVGFK-------------------FVR 391

  Fly   385 KLIGELLRRGSREEGLLR-IGGHKQKTELLYNELESTFY--QNPDNLDNLFRTATVHELSSLLKR 446
            |.|..:..:|.:.|||.| :|.:.|..:|||     .|:  :.|.::|.......:..::|.||.
Mouse   392 KCINFIETKGIKTEGLYRTVGSNIQVQKLLY-----AFFDPKCPGDVDFHNSDWDIKTITSSLKF 451

  Fly   447 WLRELPQPLLTNELIQLFYQCHTLPSID-QMNALSILCHLLPPENRNTLRSLLS-FFNIIINLKD 509
            :||.|.:|::|.:|.:.........::| ::.|:..|.:.||.:||..|..|:. ..|:..:.|:
Mouse   452 YLRNLSEPVMTYKLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIKHLVNVCEHSKE 516

  Fly   510 INKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLF-------QV 567
             |.|...|:..|..|::.      .:..:::|..:.:..|.. :..|||....|::       ||
Mouse   517 -NLMTPSNMGVIFGPTLM------RAQEDTVAAMMNIKFQNI-VVEILIEHFGKIYLGPPEDSQV 573

  Fly   568 P-----------NNLIVESQKTMMGKKGWHRHRNSNEITAKPSGKASNVGVGHDSTVINKYSTN- 620
            |           :..|..|::.:..|..::           .|....|....|..|.....::|
Mouse   574 PPVPPPRVTARRHKPITISKRLLREKTVFY-----------TSSLDENKDESHHQTPNGTITSNL 627

  Fly   621 -----LKHLHP 626
                 |:||.|
Mouse   628 DPPKLLQHLKP 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	53/242 (22%)
Ophn1	NP_001300683.1	BAR_OPHN1	19..225	CDD:153317	43/235 (18%)
		PH	266..363	CDD:278594	17/113 (15%)
		BAR-PH_GRAF_family	267..370	CDD:269953	19/119 (16%)
		RhoGAP_Graf	363..559	CDD:239839	52/227 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..665		8/33 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	681..802
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910