DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and ARHGAP12

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_060757.4	Gene:	ARHGAP12 / 94134	HGNCID:	16348	Length:	846	Species:	Homo sapiens

Alignment Length:	601	Identity:	124/601 - (20%)
Similarity:	232/601 - (38%)	Gaps:	128/601 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SNTDLHHSDDQDFSEFLNEYYLQSNSQS-----IEPEASYEDGEMEAEWLVSAGYPE---LTKPF 59
            |..|..:..||:.......||..|.|||     ..|....|:.:.....|.::.|..   |....
Human   305 SKGDFQNPGDQELLSSEENYYSTSYSQSDSQCGSPPRGWSEELDERGHTLYTSDYTNEKWLKHVD 369

  Fly    60 EQGLEV------SKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFR--- 115
            :||.:.      |:.:.|     |.|.:|.:..|     .:.::.|:..|..::|.:...:|
Human   370 DQGRQYYYSADGSRSEWE-----LPKYNASSQQQ-----REIIKSRSLDRRLQEPIVLTKWRHST 424

  Fly   116 ---EFDEQGTVTRSRSATPDSLDSLQIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQN 177
               :.:::.:.|.|:...|:            |.|.|:    ..|:.:||....:|  |.|...|
Human   425 IVLDTNDKESPTASKPCFPE------------NESSPS----SPKHQDTASSPKDQ--EKYGLLN 471

  Fly   178 LRRTPSAPPKSGTYADIFRGSQVRCDIPLYSADGVELLGYSRI-------GTIQFPRNRSVSDPF 235
            :.:...            .|.:||.:   :.:....|.|.|.:       .|..|..|:|..:..
Human   472 VTKIAE------------NGKKVRKN---WLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFT 521

  Fly   236 CSIGRSKESRSENDARSQK-------KKSSEVLSASENECGRLLPMPYNVLSFESICRDSSSLDS 293
            ..:..:....:..|..|:|       ::.:|:|..|:|:  .::...:.||| .:|...:...|.
Human   522 VDLKGATIEMASKDKSSKKNVFELKTRQGTELLIQSDND--TVINDWFKVLS-STINNQAVETDE 583

  Fly   294 CEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELATIFD----RNKVSLDK---RKPFKRRRK 351
            ....:..|.|.....|    .|.:.|..:.:...::::|..    :.|.:|.|   |:|..:..:
Human   584 GIEEEIPDSPGIEKHD----KEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVR 644

  Fly   352 EEG----NLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHK---QK 409
            |:|    .:||.::..|.:|:   .||    ||.|::..|..:...|...:|:.|:.|:.   ||
Human   645 EKGYIKDQVFGSNLANLCQRE---NGT----VPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQK 702

  Fly   410 TELLYNELESTFYQNPDNLD-NLFRTATVHELSSLLKRWLRELPQPLLT----NELIQLFYQCHT 469
            .....|        :.:.|| |..:...:|.::..||.:.||||:||.|    |:.:....|
Human   703 LRFAVN--------HDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQ--- 756

  Fly   470 LPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPR---- 530
             ....::.|:..|...||..|::|::.|......:|...:.|:|...::|.:..|::..|.
Human   757 -EPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETG 820

  Fly   531 --YIHPSDNNSIAEQV 544
              .:|....|.|.|.:
Human   821 NIAVHTVYQNQIVELI 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	49/203 (24%)
ARHGAP12	NP_060757.4	SH3-WW_linker	71..266	CDD:293224
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..241
		WW	268..298	CDD:238122
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..316		3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..466		10/55 (18%)
		PH_ARHGAP9-like	465..576	CDD:270053	24/128 (19%)
		PH	479..574	CDD:278594	20/100 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	580..629		8/52 (15%)
		RhoGAP_ARHGAP27_15_12_9	654..839	CDD:239868	49/202 (24%)
		SH3_ARHGAP12	15..74	CDD:213003
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910