DRSC/TRiP Functional Genomics Resources

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Protein Alignment conu and ARHGAP12

DIOPT Version :10

Sequence 1:NP_001036454.1 Gene:conu / 3355133 FlyBaseID:FBgn0039994 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_060757.4 Gene:ARHGAP12 / 94134 HGNCID:16348 Length:846 Species:Homo sapiens


Alignment Length:601 Identity:124/601 - (20%)
Similarity:232/601 - (38%) Gaps:128/601 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SNTDLHHSDDQDFSEFLNEYYLQSNSQS-----IEPEASYEDGEMEAEWLVSAGYPE---LTKPF 59
            |..|..:..||:.......||..|.|||     ..|....|:.:.....|.::.|..   |....
Human   305 SKGDFQNPGDQELLSSEENYYSTSYSQSDSQCGSPPRGWSEELDERGHTLYTSDYTNEKWLKHVD 369

  Fly    60 EQGLEV------SKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFR--- 115
            :||.:.      |:.:.|     |.|.:|.:..|     .:.::.|:..|..::|.:...:|   
Human   370 DQGRQYYYSADGSRSEWE-----LPKYNASSQQQ-----REIIKSRSLDRRLQEPIVLTKWRHST 424

  Fly   116 ---EFDEQGTVTRSRSATPDSLDSLQIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQN 177
               :.:::.:.|.|:...|:            |.|.|:    ..|:.:||....:|  |.|...|
Human   425 IVLDTNDKESPTASKPCFPE------------NESSPS----SPKHQDTASSPKDQ--EKYGLLN 471

  Fly   178 LRRTPSAPPKSGTYADIFRGSQVRCDIPLYSADGVELLGYSRI-------GTIQFPRNRSVSDPF 235
            :.:...            .|.:||.:   :.:....|.|.|.:       .|..|..|:|..:..
Human   472 VTKIAE------------NGKKVRKN---WLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFT 521

  Fly   236 CSIGRSKESRSENDARSQK-------KKSSEVLSASENECGRLLPMPYNVLSFESICRDSSSLDS 293
            ..:..:....:..|..|:|       ::.:|:|..|:|:  .::...:.||| .:|...:...|.
Human   522 VDLKGATIEMASKDKSSKKNVFELKTRQGTELLIQSDND--TVINDWFKVLS-STINNQAVETDE 583

  Fly   294 CEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELATIFD----RNKVSLDK---RKPFKRRRK 351
            ....:..|.|.....|    .|.:.|..:.:...::::|..    :.|.:|.|   |:|..:..:
Human   584 GIEEEIPDSPGIEKHD----KEKEQKDPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVR 644

  Fly   352 EEG----NLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHK---QK 409
            |:|    .:||.::..|.:|:   .||    ||.|::..|..:...|...:|:.|:.|:.   ||
Human   645 EKGYIKDQVFGSNLANLCQRE---NGT----VPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQK 702

  Fly   410 TELLYNELESTFYQNPDNLD-NLFRTATVHELSSLLKRWLRELPQPLLT----NELIQLFYQCHT 469
            .....|        :.:.|| |..:...:|.::..||.:.||||:||.|    |:.:....|   
Human   703 LRFAVN--------HDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQ--- 756

  Fly   470 LPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPR---- 530
             ....::.|:..|...||..|::|::.|......:|...:.|:|...::|.:..|::..|.    
Human   757 -EPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETG 820

  Fly   531 --YIHPSDNNSIAEQV 544
              .:|....|.|.|.:
Human   821 NIAVHTVYQNQIVELI 836

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
conuNP_001036454.1 RhoGAP_ARHGAP18 356..576 CDD:239856 49/203 (24%)
ARHGAP12NP_060757.4 SH3_ARHGAP12 15..74 CDD:213003
SH3-WW_linker 71..266 CDD:435468
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 152..241
PRP40 259..>412 CDD:227435 25/116 (22%)
WW 268..298 CDD:238122
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 293..316 3/10 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..466 10/55 (18%)
PH_ARHGAP9-like 465..576 CDD:270053 24/128 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 580..629 8/52 (15%)
RhoGAP_ARHGAP27_15_12_9 654..839 CDD:239868 49/202 (24%)
Blue background indicates that the domain is not in the aligned region.

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