Protein Alignment conu and ARHGAP18

DIOPT Version :9

• Sequence 1: NP_001036454.1
• Gene: conu / 3355133
• FlyBaseID: FBgn0039994
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_277050.2
• Gene: ARHGAP18 / 93663
• HGNCID: 21035
• Length: 663
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 160/583 - (27%)
• Similarity: 257/583 - (44%)
• Gaps: 132/583 - (22%)

  Fly    19 LNEYYLQSNSQSIEPEASYED-----------GEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEP 72
            :.:|:::..:.....|.|.||           ||:|.|||..||   |:..|.:.....::.: .
Human    75 MEDYWIELENIKKSSENSQEDQEVVVVKEPDEGELEEEWLKEAG---LSNLFGESAGDPQESI-V 135

  Fly    73 ILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTRSRSATPDSLDSL 137
            .|:||::..|.|:.:.|.|:::|  :|.|::..:.||:||:|.:..|      |:...|...:|
Human   136 FLSTLTRTQAAAVQKRVETVSQT--LRKKNKQYQIPDVRDIFAQQRE------SKETAPGGTES- 191

  Fly   138 QIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADIFRGSQVRC 202
                    .||.|..|.|:...:.|...|.:...|        .|...|...|
Human   192 --------QSLRTNENKYQGRDDEASNLVGEEKLI--------PPEETPAPET------------ 228

  Fly   203 DIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESRSENDARSQKKKSSEVLSASENE 267
            ||.|                                    |......|.:||:.|.|.:..|:.
Human   229 DINL------------------------------------EVSFAEQALNQKESSKEKIQKSKG- 256

  Fly   268 CGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIP--STLFTDVVLISETDMKRLQTILWLELA 330
                               |.::|.|..      :|  .|..|.:..::..|||::..:..:||.
Human   257 -------------------DDATLPSFR------LPKDKTGTTRIGDLAPQDMKKVCHLALIELT 296

  Fly   331 TIFDRNKVSLDKRKPFKRRRKEEGNLFGVSINALIRRDQ-QVTGTDSSLVPLFLEKLIGELLRRG 394
            .::|...:.|.::|..|.:.|:.| ||.|.:.||:.:|| :|.|   ..:||..:|||..:..||
Human   297 ALYDVLGIELKQQKAVKIKTKDSG-LFCVPLTALLEQDQRKVPG---MRIPLIFQKLISRIEERG 357

  Fly   395 SREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNE 459
            ...||||||.|...:.:.|..|||:.||:...|.:::.:    |:.:||||.::||||||||:.|
Human   358 LETEGLLRIPGAAIRIKNLCQELEAKFYEGTFNWESVKQ----HDAASLLKLFIRELPQPLLSVE 418

  Fly   460 LIQLFYQCHTLPS-IDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMA 523
            .::.|.....||: ..|:.||::|..|||..||:||::||.|...:|:.|:.|||.|.|||.:||
Human   419 YLKAFQAVQNLPTKKQQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMA 483

  Fly   524 PSMFPPRYIHPSD-NNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLI--VESQKTMMGKK 583
            |::|   ..|... .:|...:..|||......::||...:.|:.:|..::  |..|.|...||
Human   484 PNLF---MCHALGLKSSEQREFVMAAGTANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENHKK 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	84/224 (38%)
ARHGAP18	NP_277050.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..37
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..227		14/70 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	243..277		11/59 (19%)
		RhoGAP_ARHGAP18	321..534	CDD:239856	83/222 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148557
Domainoid	1	1.000	114	1.000	Domainoid score	I6069
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	185	1.000	Inparanoid score	I3952
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D309300at33208
OrthoFinder	1	1.000	-	-		FOG0002326
OrthoInspector	1	1.000	-	-		otm42220
orthoMCL	1	0.900	-	-		OOG6_108161
Panther	1	1.100	-	-	O	PTHR14963
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5254
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.830