DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and STARD13

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_821074.1	Gene:	STARD13 / 90627	HGNCID:	19164	Length:	1113	Species:	Homo sapiens

Alignment Length:	384	Identity:	92/384 - (23%)
Similarity:	168/384 - (43%)	Gaps:	62/384 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 TIQFPRNRSVSDPFCSIGRSKESRSENDARS-QKKKSSEVLSASENECGRLLPMPYNVLSFESIC 285
            |:.|..| |||:     ||:..|..|.|..| .:.:...|....::..|..|..|...|.:.|.
Human   533 TLDFEGN-SVSE-----GRTTPSDVERDVTSLNESEPPGVRDRRDSGVGASLTRPNRRLRWNSF- 590

  Fly   286 RDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELATIFDRNKVSLDKR------K 344
                      .|.....|:.....:...:.:.:..||....|.|..|.:::.:| :|.      .
Human   591 ----------QLSHQPRPAPASPHISSQTASQLSLLQRFSLLRLTAIMEKHSMS-NKHGWTWSVP 644

  Fly   345 PFKRRRK----EEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGG 405
            .|.:|.|    ::..:|||.:...::|..|.       :|..:::.:..|......:.||.|..|
Human   645 KFMKRMKVPDYKDKAVFGVPLIVHVQRTGQP-------LPQSIQQALRYLRSNCLDQVGLFRKSG 702

  Fly   406 HKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTL 470
            .|.:...| .::...|   |:|::  :...:.::::.::|::.|:||:||.||:|.:.|...:..
Human   703 VKSRIHAL-RQMNENF---PENVN--YEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQY 761

  Fly   471 PSIDQ-MNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMF------- 527
            .|.:| :.|:.....||..|||..|::||.|.|.::||.:.|:|...|:|..:|||:|
Human   762 VSKEQRLQAVQAAILLLADENREVLQTLLCFLNDVVNLVEENQMTPMNLAVCLAPSLFHLNLLKK 826

  Fly   528 --PPRYIHPS------DNNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVESQKT 578
              .||.|...      |...:.|.:..|.....    :|:..::||:||:.|:.:|:.:
Human   827 ESSPRVIQKKYATGKPDQKDLNENLAAAQGLAH----MIMECDRLFEVPHELVAQSRNS 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	61/235 (26%)
STARD13	NP_821074.1	SAM_DLC2	57..120	CDD:188991
		SAM	61..120	CDD:197735
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..254
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	307..346
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..580		14/49 (29%)
		RhoGAP_DLC1	657..874	CDD:239840	60/233 (26%)
		START_STARD13-like	900..1104	CDD:176918
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810