DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and BEM2

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_011082.3	Gene:	BEM2 / 856899	SGDID:	S000000957	Length:	2167	Species:	Saccharomyces cerevisiae

Alignment Length:	511	Identity:	115/511 - (22%)
Similarity:	196/511 - (38%)	Gaps:	117/511 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 LNKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTR---------SRSATPDSLDSLQIDEAWTNNS 147
            :||..|.:|    |:..:...:...|.|||....         .|.|.  .|:.|...|....||
Yeast  1696 VNKVYRKKT----KKVSESEAISERFQEQGVFNEILVNEIEKIKREAR--KLEVLLDQEKILKNS 1754

  Fly   148 LPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADIFRGSQVRCDIPLYSADGV 212
            ......|.:||.::.|.....|:..: ..|:.:.....|..|:..:....::.|.|
Yeast  1755 AALHQAVPKKNRKSVIISGTHSDNDH-SYNINKNTGQTPSLGSVMESNNSARNRRD--------- 1809

  Fly   213 ELLGYSRIGTIQFPRNRS--VSD----------------PFCSIG---RSKESRSENDARSQKKK 256
                 ||   ..|..|||  ||:                || |||   .|..:.|.|...||:..
Yeast  1810 -----SR---ASFSTNRSSVVSNSSHNGVSKKIGGFFRRPF-SIGGFNTSSSNYSLNSILSQEVS 1865

  Fly   257 SSEVLSAS---ENECGRL--LPMPYNVLSFE--SICRDSSSLDSCEVLDTCDIPSTLFTDVVLIS 314
            |::.:..|   |.:..:|  |...|::.:||  ||         .|:::..:||:..:...:::.
Yeast  1866 SNKSILPSILPEVDSMQLHDLKPSYSLKTFEIKSI---------MEIINHRNIPAYYYAFKIVMQ 1921

  Fly   315 ETDMKRLQTIL------WLELATIFDRNKVSLDKRKPF---KRRRKEEGNLFGVSINALIRRDQQ 370
            ......:||..      |:::        :...||..|   |.:.|....:|||.:..:..|
Yeast  1922 NGHEYLIQTASSSDLTEWIKM--------IKASKRFSFHSKKYKGKTHNKIFGVPLEDVCER--- 1975

  Fly   371 VTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLF--- 432
                :::|:|..:.||:.|:..||..|.||.||.|.......|.|.     :......||.|
Yeast  1976 ----ENTLIPTIVVKLLEEIELRGLDEVGLYRIPGSIGSINALKNA-----FDEEGATDNSFTLE 2031

  Fly   433 --RTATVHELSSLLKRWLRELPQPLLTNELIQLF------YQCHTLPSIDQMNALSILCHLLPPE 489
              |...|:.::...|.:|||||..|.::.::..|      |:.|.:.:.:....::.|...||..
Yeast  2032 DDRWFEVNAIAGCFKMYLRELPDSLFSHAMVNDFTDLAIKYKAHAMVNEEYKRMMNELLQKLPTC 2096

  Fly   490 NRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSD-NNSIAEQV 544
            ...||:.::...|.:......|||:..|:|.:.:.|     :|:..| .||:..::
Yeast  2097 YYQTLKRIVFHLNKVHQHVVNNKMDASNLAIVFSMS-----FINQEDLANSMGSRL 2147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	50/201 (25%)
BEM2	NP_011082.3	RasGEF	592..860	CDD:214539
		REM	1120..1291	CDD:413353
		PH	<1877..1948	CDD:395117	14/87 (16%)
		RhoGAP	1981..2134	CDD:395495	41/162 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910