DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and LRG1

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_010041.2	Gene:	LRG1 / 851358	SGDID:	S000002399	Length:	1017	Species:	Saccharomyces cerevisiae

Alignment Length:	557	Identity:	122/557 - (21%)
Similarity:	216/557 - (38%)	Gaps:	188/557 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 VRTLNKTVRVRTKSRPKR-----------------KPDIRDVFREFDEQGTVTRSRSATPDSLDS 136
            :||||...|:|::....|                 :.|:.|..::.|.:..|
Yeast   534 IRTLNDIKRLRSRRESVRVTHNKQQARKSVILETAETDLNDPTKQGDSKNLV------------- 585

  Fly   137 LQIDEAWTNNSLPTFVNVYEKNTET-------AIQCVEQSNEI---------YLKQNLRRTPS-A 184
            :|.|:..::..:.|..||: .||:|       .|...||:.|:         .||:....|.: .
Yeast   586 IQTDDPSSSQQVSTRENVF-SNTKTLTLDDISRIVAAEQARELRPNAFAHFKKLKETDDETSNVV 649

  Fly   185 PPKSGTYADIFRGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESRSEND 249
            |.|||.|                         ||.:.|::....|::|   .|:...|:..|:.|
Yeast   650 PKKSGVY-------------------------YSELSTMELSMIRAIS---LSLLAGKQLISKTD 686

  Fly   250 ARSQKKKSSEVLSASENECGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLIS 314
            ..                                                       :|.:|.:.
Yeast   687 PN-------------------------------------------------------YTSLVSMV 696

  Fly   315 ETDMKRLQTILWLELATIFDRNKV--SLDKRKPFKRRRKEEGNLFGVSINALIRRDQQVTGTDSS 377
            .::.|::....|       :|.|:  |::.:||..:      .:||..::.|..:    .|.||.
Yeast   697 FSNEKQVTGSFW-------NRMKIMMSMEPKKPITK------TVFGAPLDVLCEK----WGVDSD 744

  Fly   378 L--------VPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRT 434
            |        :|:.:::||..|.:.....||:.|..|:.::...|...::|...:.||     |..
Yeast   745 LGVGPVKIRIPIIIDELISSLRQMDMSVEGIFRKNGNIRRLRELTANIDSNPTEAPD-----FSK 804

  Fly   435 ATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQMNALSILCH-LLPPENRNTLRSLL 498
            ....:||:|||:::||||||:|:.:|.:|:.:...:...|:...:.:|.: |||..|||.|.:||
Yeast   805 ENAIQLSALLKKFIRELPQPILSTDLYELWIKAAKIDLEDEKQRVILLIYSLLPTYNRNLLEALL 869

  Fly   499 SF------FNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQ----VRMAAQ---- 549
            ||      |:.|.|... :||::||::|::.|::...|:...|::|...|.    |...||
Yeast   870 SFLHWTSSFSYIENEMG-SKMDIHNLSTVITPNILYLRHKEISNDNVPDEPESGLVDSFAQNKGE 933

  Fly   550 ----CCRLTNILILRGEKLFQVPN---NLI--VESQK 577
                ...:.:.||...|::..||.   ||:  |:.||
Yeast   934 NYFLAIEIVDYLITHNEEMAMVPKFLMNLLKDVQLQK 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	71/251 (28%)
LRG1	NP_010041.2	LIM1_Lrg1p_like	28..90	CDD:188777
		LIM	98..149	CDD:259829
		LIM3_Lrg1p_like	419..475	CDD:188779
		RhoGAP_fLRG1	728..959	CDD:239862	68/240 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I2077
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910