DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and Ralbp1

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001380593.1	Gene:	Ralbp1 / 84014	RGDID:	621134	Length:	647	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	97/499 - (19%)
Similarity:	168/499 - (33%)	Gaps:	154/499 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 IGTIQFP---RNRSVSDPFCSIGRSKESRSENDARSQKKKSSEVLSASENECGRLLPMPYNVLSF 281
            |...:||   |....|.|...:....:..|:::....|||            |:..........:
  Rat    33 ISPTKFPGLYRTGEPSPPHDILHEPPDIVSDDEKDHGKKK------------GKFKKKEKRTEGY 85

  Fly   282 ESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELATIFDRNKVSLDKRKPF 346
            .:...|||.       |..:.||            .|||.:.|      .:|.:...|..|.|.|
  Rat    86 AAFQEDSSG-------DEAESPS------------KMKRSKGI------HVFKKPSFSKKKEKDF 125

  Fly   347 K------------RRRKEEGN------------------------------------------LF 357
            |            .:.|||.:                                          :|
  Rat   126 KIKEKPKEEKHKEEKHKEEKHKEKKCKDLTAADVVKQWKEKKKKKKPTQEPEVPQTDAPSLRPIF 190

  Fly   358 GVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTF- 421
            |..:...:.|....   |...:|....:.:..:.:.|.:.||:.|:.|.|.|.:    ||::.:
  Rat   191 GAPLADAVERTMMY---DGIRLPAVFRECVDYMEKHGMKCEGIYRVSGIKSKVD----ELKAAYD 248

  Fly   422 YQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQ-CHTLPSIDQMNALSILCHL 485
            .:...||:. :...||   :||||::||:||:.|||.||:..|.: |.....::::.....|...
  Rat   249 REESPNLEE-YEPNTV---ASLLKQYLRDLPENLLTKELMPRFEEACGRTTEVEKVQEFQRLLRE 309

  Fly   486 LPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPS-----------------MF------ 527
            ||..|...|..|:...:.:|..:...|||:.|::.:::|:                 :|
  Rat   310 LPEYNHLLLSWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVLFTHVQELFGTVVLK 374

  Fly   528 ----PPRYIH-------PSDNNSIAEQVRMAAQCCRLTNIL----------ILRGEKLFQVPNNL 571
                |.|:.:       |.....|.|::|...   .|.|.|          :.:.|:|::|...|
  Rat   375 QVTRPLRWSNMATMPTLPETQAGIKEEIRRQE---FLLNCLHRDLQGGIKDLSKEERLWEVQRIL 436

  Fly   572 IVESQKTMMGKKGWHRHRNSNEITAKPSGKASNVGVGHDSTVIN 615
            ....:|....|:.....:.:.||.:......|......:..|||
  Rat   437 TALKRKLREAKRQECETKIAQEIASLSKEDVSKEETNENEEVIN 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	59/265 (22%)
Ralbp1	NP_001380593.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..151		30/154 (19%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9PT60	102..119		5/22 (23%)
		Mediates association with membranes and could form transmembrane domains. /evidence=ECO:0000250\|UniProtKB:Q15311	154..219		5/67 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..186		0/22 (0%)
		RhoGap_RalBP1	190..371	CDD:239846	46/191 (24%)
		SMC_prok_B	<395..>594	CDD:274008	18/89 (20%)
		Mediates interaction with RALA and RALB. /evidence=ECO:0000250\|UniProtKB:Q15311	403..499		16/81 (20%)
		Mediates interaction with REPS1 and REPS2. /evidence=ECO:0000269\|PubMed:9395447, ECO:0000269\|PubMed:9422736	500..647
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..550
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..647
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910