DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and ARHGAP39

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_079527.1	Gene:	ARHGAP39 / 80728	HGNCID:	29351	Length:	1114	Species:	Homo sapiens

Alignment Length:	572	Identity:	122/572 - (21%)
Similarity:	198/572 - (34%)	Gaps:	190/572 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EYYLQ-SNSQSIEPEASYEDGEMEAEWLVSAG--YPELT--KPFEQGLEVSKKDLEPILTTLSKP 80
            |.||. |.|:.:...|.:|........:.|:.  :|..|  ||      .|:.|:|...:.....
Human   646 EPYLHPSQSEDLAACAQFESSRQSRSGVPSSSCVFPTFTLRKP------SSETDIENWASKHFNK 704

  Fly    81 HAEAIVQLVRTLNKTVRVRTKSRPKRKPDI----RDVFREFDEQGTVTR----SRSATPDSLD-S 136
            |.:.:.:  |.::....:...|...:||.|    |.|.:|..|...:.:    .|.|..|.|. :
Human   705 HTQGLFR--RKVSIANMLAWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVA 767

  Fly   137 LQI-DEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRR------------TPSAPPKS 188
            |:: .:.|:...|         ..|..||...|:.|.:..::|.|            .|:  ||.
Human   768 LEVATKGWSVQGL---------RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPT--PKF 821

  Fly   189 GTYAD--IFRGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESR--SEND 249
            .:|.:  |:|.                                  .||   :..:|.::  .|..
Human   822 HSYLEGYIYRH----------------------------------MDP---VNDTKVTQHIKELL 849

  Fly   250 ARSQKKKSSEVLSASENECGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLIS 314
            .|:.||||..          |..|.||                                    :.
Human   850 ERNTKKKSKL----------RKKPKPY------------------------------------VE 868

  Fly   315 ETDMKRLQTIL-----WLELATIFDRNKVSLDKRKPFKRRRKEE----------GNLFGVSINAL 364
            |.|...:.|..     .|:.|.:       ...:|..|:...||          .::||.::
Human   869 EPDGVAISTYAKYCYHKLQKAAL-------TGAKKGLKKPNVEEIRHAKNAVFSPSMFGSAL--- 923

  Fly   365 IRRDQQVTGTD-----SSLVPLFLEKLIGELLR-RGSREEGLLRIGGHKQKTELLYNELESTFYQ 423
                |:|.|..     ...:|....:|..|:|. .|.:.||:.|:.|...:...|  :|:...::
Human   924 ----QEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNAL--KLQVDQWK 982

  Fly   424 NPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFY-QCHTLPSIDQMNALSILCHLLP 487
            .|..|::      .|..:||||.|.|||.:||:.:|    || ||  :...|...|...:.|.||
Human   983 VPTGLED------PHVPASLLKLWYRELEEPLIPHE----FYEQC--IAHYDSPEAAVAVVHALP 1035

  Fly   488 PENRNTLRSLLSFFNIIINLKD--INKMNVHNVATIMAPSMF-----PPRYI 532
            ..||..|..|:.|..:.:...:  :.||:|.|:|.:|||:..     .||.|
Human  1036 RINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQSDDPRVI 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	55/191 (29%)
ARHGAP39	NP_079527.1	WW	69..95	CDD:278809
		MyTH4	767..907	CDD:279165	38/240 (16%)
		RhoGAP_KIAA1688	919..1104	CDD:239854	55/190 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910