Protein Alignment conu and ARHGAP28

DIOPT Version :10

• Sequence 1: NP_001036454.1
• Gene: conu / 3355133
• FlyBaseID: FBgn0039994
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001353159.1
• Gene: ARHGAP28 / 79822
• HGNCID: 25509
• Length: 729
• Species: Homo sapiens
• Alignment Length: 664
• Identity: 160/664 - (24%)
• Similarity: 268/664 - (40%)
• Gaps: 150/664 - (22%)

  Fly     1 MNSNTDLHHSDDQDFSEFLNEYYLQSNSQSIEPEASYED-------------------------- 39
            |.||..||   ...||        :|||::....||.||
Human    53 MLSNESLH---PPAFS--------RSNSEASVDSASMEDFWREIESIKDSSMGGQEEPPPAEVTP 106

  Fly    40 ---GEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTK 101
               ||:|||||...|...|....|:      :|.:.:|:||::..|.|:.:...|..:|:|.:.|
Human   107 VDEGELEAEWLQDVGLSTLISGDEE------EDGKALLSTLTRTQAAAVQKRYHTYTQTMRKKDK 165

  Fly   102 SRPKRKPDIRDVFREFDEQGTVTRSRSATPDSLDSLQIDEAWTNNSLPTFVNVYEKNTETAIQCV 166
            ...:   |:||:|      |.   |.|...|:                               |.
Human   166 QSIR---DVRDIF------GV---SESPPRDT-------------------------------CG 187

  Fly   167 EQSNEIYLKQNLRRTPSAPPKSGTYADIFRGSQVRCDIPLYS---ADGVELLGYSRIGTIQFPRN 228
            ..:|::...:..|..|.....||:..|         |..|.|   :|..:    .:.|:...||:
Human   188 NHTNQLDGTKEERELPRVIKTSGSMPD---------DASLNSTTLSDASQ----DKEGSFAVPRS 239

  Fly   229 RSVSD-------PFCSIGRSKESRSENDARSQKKKSSEVLSASENECGRLLPMPYNVLSFESICR 286
            .||:.       |..|.|..:..:...:|.|......:.:.....|..  ..:.|:.:..|::.|
Human   240 DSVAILETIPVLPVHSNGSPEPGQPVQNAISDDDFLEKNIPPEAEELS--FEVSYSEMVTEALKR 302

  Fly   287 DSSSLDSCE----VLDTCDIPSTLF--TDVVLISETDMKRLQTILWLELATIFDRNKVSLDKRKP 345
            :.......:    ||...::..|.|  |:...:|..|||:::.:..:||...||...:.|.:.|.
Human   303 NKLKKSEIKKEDYVLTKFNVQKTRFGLTEAGDLSAEDMKKIRHLSLIELTAFFDAFGIQLKRNKT 367

  Fly   346 FKRRRKEEGNLFGVSINALIRRDQQVTGTDSSL-VPLFLEKLIGELLRRGSREEGLLRIGGHKQK 409
            .|.:.::.| :|||.:..|:..|::   .|..: |||.|:|...::...|...||:.|:.|...|
Human   368 EKVKGRDNG-IFGVPLTVLLDGDRK---KDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAK 428

  Fly   410 TELLYNELESTFYQNPDNLDNLFRTATVH-ELSSLLKRWLRELPQPLLTNELIQLFYQ-CHTLPS 472
            .:....||::.|     |.|........| |.:.:||.:.||||..|...|.|..|.. ....|.
Human   429 VKQYREELDAKF-----NADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPH 488

  Fly   473 ID-QMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSD 536
            :. |..||.::...||..||:..::|::|||.:|..:..|:|::.|::|:|||::|..|..|
Human   489 VKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKH--- 550

  Fly   537 NNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVE----SQKTMMGKKGWH------RHRNS 591
              |..|::.:|.....:..:::...:.|::||:.||.:    ::.||:.||...      |.:..
Human   551 --SDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLRRKTL 613

  Fly   592 NEITAKPSGKASNV 605
            ...||.|  |.|.|
Human   614 ERETASP--KTSKV 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	65/227 (29%)
ARHGAP28	NP_001353159.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..42
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	55..105		13/60 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	176..236		16/106 (15%)
		RhoGAP_ARHGAP18	377..588	CDD:239856	65/223 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	612..631		6/16 (38%)