DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and ARHGAP28

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001353159.1	Gene:	ARHGAP28 / 79822	HGNCID:	25509	Length:	729	Species:	Homo sapiens

Alignment Length:	664	Identity:	160/664 - (24%)
Similarity:	268/664 - (40%)	Gaps:	150/664 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNSNTDLHHSDDQDFSEFLNEYYLQSNSQSIEPEASYED-------------------------- 39
            |.||..||   ...||        :|||::....||.||
Human    53 MLSNESLH---PPAFS--------RSNSEASVDSASMEDFWREIESIKDSSMGGQEEPPPAEVTP 106

  Fly    40 ---GEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTK 101
               ||:|||||...|...|....|:      :|.:.:|:||::..|.|:.:...|..:|:|.:.|
Human   107 VDEGELEAEWLQDVGLSTLISGDEE------EDGKALLSTLTRTQAAAVQKRYHTYTQTMRKKDK 165

  Fly   102 SRPKRKPDIRDVFREFDEQGTVTRSRSATPDSLDSLQIDEAWTNNSLPTFVNVYEKNTETAIQCV 166
            ...:   |:||:|      |.   |.|...|:                               |.
Human   166 QSIR---DVRDIF------GV---SESPPRDT-------------------------------CG 187

  Fly   167 EQSNEIYLKQNLRRTPSAPPKSGTYADIFRGSQVRCDIPLYS---ADGVELLGYSRIGTIQFPRN 228
            ..:|::...:..|..|.....||:..|         |..|.|   :|..:    .:.|:...||:
Human   188 NHTNQLDGTKEERELPRVIKTSGSMPD---------DASLNSTTLSDASQ----DKEGSFAVPRS 239

  Fly   229 RSVSD-------PFCSIGRSKESRSENDARSQKKKSSEVLSASENECGRLLPMPYNVLSFESICR 286
            .||:.       |..|.|..:..:...:|.|......:.:.....|..  ..:.|:.:..|::.|
Human   240 DSVAILETIPVLPVHSNGSPEPGQPVQNAISDDDFLEKNIPPEAEELS--FEVSYSEMVTEALKR 302

  Fly   287 DSSSLDSCE----VLDTCDIPSTLF--TDVVLISETDMKRLQTILWLELATIFDRNKVSLDKRKP 345
            :.......:    ||...::..|.|  |:...:|..|||:::.:..:||...||...:.|.:.|.
Human   303 NKLKKSEIKKEDYVLTKFNVQKTRFGLTEAGDLSAEDMKKIRHLSLIELTAFFDAFGIQLKRNKT 367

  Fly   346 FKRRRKEEGNLFGVSINALIRRDQQVTGTDSSL-VPLFLEKLIGELLRRGSREEGLLRIGGHKQK 409
            .|.:.::.| :|||.:..|:..|::   .|..: |||.|:|...::...|...||:.|:.|...|
Human   368 EKVKGRDNG-IFGVPLTVLLDGDRK---KDPGVKVPLVLQKFFEKVEESGLESEGIFRLSGCTAK 428

  Fly   410 TELLYNELESTFYQNPDNLDNLFRTATVH-ELSSLLKRWLRELPQPLLTNELIQLFYQ-CHTLPS 472
            .:....||::.|     |.|........| |.:.:||.:.||||..|...|.|..|.. ....|.
Human   429 VKQYREELDAKF-----NADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFISLMERGPH 488

  Fly   473 ID-QMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSD 536
            :. |..||.::...||..||:..::|::|||.:|..:..|:|::.|::|:|||::|..|..|
Human   489 VKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMAPNLFFSRSKH--- 550

  Fly   537 NNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVE----SQKTMMGKKGWH------RHRNS 591
              |..|::.:|.....:..:::...:.|::||:.||.:    ::.||:.||...      |.:..
Human   551 --SDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQLPSVRKLLRRKTL 613

  Fly   592 NEITAKPSGKASNV 605
            ...||.|  |.|.|
Human   614 ERETASP--KTSKV 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	65/227 (29%)
ARHGAP28	NP_001353159.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..42
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..105		13/60 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..236		16/106 (15%)
		RhoGAP_ARHGAP18	377..588	CDD:239856	65/223 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	612..631		6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148556
Domainoid	1	1.000	114	1.000	Domainoid score	I6069
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	185	1.000	Inparanoid score	I3952
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D309300at33208
OrthoFinder	1	1.000	-	-		FOG0002326
OrthoInspector	1	1.000	-	-		otm42220
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860