DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and si:dkey-33c9.6

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_021327566.1	Gene:	si:dkey-33c9.6 / 795086	ZFINID:	ZDB-GENE-130530-592	Length:	829	Species:	Danio rerio

Alignment Length:	667	Identity:	152/667 - (22%)
Similarity:	236/667 - (35%)	Gaps:	198/667 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DQDFSEFLNEYYLQSNSQSIEPEASYEDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTT 76
            ||.|...........:|.:::.:.::|              ..|.||.::   |.|..|  :|..
Zfish   205 DQRFRILAESMMSSKSSDNVKTKYTFE--------------ALLYKPLDR---VMKTTL--VLHD 250

  Fly    77 LSK----PHAEAIVQLVRTLNKTVRVRTK-----------------SRPKRKPDIRDVF-REFDE 119
            |.|    .|.::|     ||.:.:|:.:.                 .|.:|:..:||.| .:..|
Zfish   251 LWKHTPPEHPDSI-----TLQEALRLSSSFMSGVNERSQCKQPVMLCRGERRQLMRDGFVVDVCE 310

  Fly   120 QGTVTRSRSATPDSLDSLQIDEA--------------------WTNNSLPTFVNVYE-KNTETAI 163
            .|...|......|.|...::..|                    ||...||:  :.|: |.::|.:
Zfish   311 SGHNLRHLFLYTDMLLCAKLTNAGRQAQYRFCWYLPLVGLKLHWTAEHLPS--SEYQMKISKTRV 373

  Fly   164 QCVEQSNEIYLKQNLRRTPSAPPKSGTYA-DIFRGSQVRCDIPLYSADGVELLGYSRIGTIQFPR 227
            :..:      |||.|.:.......|.:.| |..|.....|:|.|.:            .|..|
Zfish   374 KMYQ------LKQALLQHMKGSKGSVSRAVDRLRRKLEECEIWLLT------------NTPSF-- 418

  Fly   228 NRSVSDPFCSIGRSKESR--SENDARSQKKKSSEVLSASENECGRLL-PMPYNVLSFESIC---- 285
               ..|...:.|:|...|  |..|....|       .|.|.:||..: .:|.::||..|.|
Zfish   419 ---TLDLHSTSGKSHTVRLLSLYDLNEWK-------DAIEKQCGNCIETVPPDLLSVTSSCIKLR 473

  Fly   286 ----------RDSSSLDSC-----EVLDTCDI--PSTLFTDVVLISETD-----MKRLQTIL--- 325
                      :.:.|...|     .|...|.:  ||:.:..|    |.|     .:|.||.|
Zfish   474 MTQQPPLHCVQSNESAQICGSLYVMVQSACGLQHPSSAYVCV----EVDGFECYDRRKQTSLSAF 534

  Fly   326 -----W-LELATIFD-----------------------RNKVSLDKRKPFKRRRKEEGNLFGVSI 361
                 | .||..|.|                       |..::||....||:.:|...:|..|.:
Zfish   535 CVTPQWDEELVFIVDGAKQLFLVFVCQYENDTQNDIVGRTVLNLDPDNMFKKWKKVTCSLGHVDV 599

  Fly   362 NALIRRDQ----------------------QVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIG 404
            ...::...                      ||...:|.|||..:...:.|:.|||.:|||:.||.
Zfish   600 TLSLKYVPHPLEPPSTTPILQEPVFCVPIGQVAMQESVLVPHIVRSCVEEVERRGLKEEGIYRIS 664

  Fly   405 GHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHT 469
            |  ..||:  ..|:..|..|.....:..|:..|:.:|..||.:.||||.||:..|..........
Zfish   665 G--ASTEI--QALKYAFNTNYREAVSKLRSVDVNAVSGTLKLYFRELPLPLIPCEHFSELSDALD 725

  Fly   470 L--PSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYI 532
            :  |.:...:.||:| ..||..|||||..||.....:...|:.|||::.|:||:..||:..|
Zfish   726 IADPFVRADSLLSLL-QSLPDVNRNTLLFLLHHLRRVAERKEENKMSLSNLATVFGPSLLRP--- 786

  Fly   533 HPSDNNSIAEQVRMAAQ 549
             |.....|:::|.:..|
Zfish   787 -PVSRVDISQEVEVQVQ 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	62/218 (28%)
si:dkey-33c9.6	XP_021327566.1	RhoGEF	71..281	CDD:214619	19/99 (19%)
		PH-like	297..453	CDD:327399	39/187 (21%)
		C2	495..605	CDD:326325	24/113 (21%)
		RhoGAP	624..812	CDD:295372	60/188 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910