DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and Arhgap12

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_006526377.1	Gene:	Arhgap12 / 75415	MGIID:	1922665	Length:	843	Species:	Mus musculus

Alignment Length:	678	Identity:	130/678 - (19%)
Similarity:	244/678 - (35%)	Gaps:	208/678 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LQSNSQSIEPEASYEDGEMEAEWLVSAGYPELTKPFE---QGLEVSKKDLEPILTTLSKPHAEAI 85
            :|.:|:|.:..:|....:|.|....:.|.|:  .|..   |.|::|:..|.|:      |.:.||
Mouse   207 IQQDSESGDELSSSSTEQMRATTPPNQGRPD--SPVYANLQELKISQSALPPL------PGSPAI 263

  Fly    86 VQL-------------VRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQG---------------- 121
             |:             ....|:|.:.||...|:...|: ...|:|...|
Mouse   264 -QVNGEWETHKDSSGRCYYYNRTTQERTWKPPRWARDV-STSRDFQSPGEQEPLSSEENYHSSCF 326

  Fly   122 TVTRSRSATPDSLDSLQID-------------EAWTNN-------------------SLPTFVNV 154
            :.:.|:..:|....|.::|             |.|..:                   .||.
Mouse   327 SQSDSQCGSPPRGWSEELDERGHTLYTSDYTKEKWLKHVDDQGRQYYYSADGSRSEWELPK---- 387

  Fly   155 YEKNTETAIQCVE-----------------QSNEIYLKQNLRRTPS----------APPKSGTYA 192
            |..:::...:.::                 :.:.|.|..|.:.:|:          :||.|..:.
Mouse   388 YNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDSNDKDSPTTTKLCLPENESPPTSSKHQ 452

  Fly   193 DIFRGSQVRCDIPLYSADGVE---LLGYSRI--------------------GTIQFPRNRSVSDP 234
            |           |..|..|.|   ||..::|                    .::.|.:.:..|..
Mouse   453 D-----------PAGSLKGQEKYGLLNVTKITENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTS 506

  Fly   235 FCSIGRSK------------------ESRSENDARSQKKKSSEVLSASENECGRLLPMPYNVLSF 281
            :....:||                  :|..:|....:.::.:|:|..|:|:.  ::...:.|||
Mouse   507 WFGSNQSKPEFTVDLKGAVIEMASKDKSSKKNVFELKTRQGTELLIQSDNDA--VINDWFKVLS- 568

  Fly   282 ESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELATIFD----RNKVSLDK 342
            .:|....:..|.....:|.|.|.....|    .|.|.|.|:.:..::.:::..    :.|.:|.|
Mouse   569 STINNQVAEADEAAEEETPDSPGVEKHD----KEKDQKELKKLRSMKGSSMDSSEQKKTKKNLKK 629

  Fly   343 ---RKPFKRRRKEEG----NLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGL 400
               |:|..:..:|:|    .:||.::..|.:|:   .||    ||.|::..|..:...|...:|:
Mouse   630 FLTRRPTLQAVREKGYIKDQVFGSNLANLCQRE---NGT----VPKFVKLCIEHVEEHGLDVDGI 687

  Fly   401 LRIGGHK---QKTELLYNELESTFYQNPDNLD-NLFRTATVHELSSLLKRWLRELPQPLLT---- 457
            .|:.|:.   ||.....|        :.:.|| |..:...:|.::..||.:.||||:||.|
Mouse   688 YRVSGNLAVIQKLRFAVN--------HDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHF 744

  Fly   458 NELIQLFYQCHTLPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIM 522
            |:.:....|    ....::.|:..|...||..|::|::.|......:|...:.|:|...::|.:.
Mouse   745 NDFVNAIKQ----EPRQRVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVF 805

  Fly   523 APSMFPPR------YIHPSDNNSIAEQV 544
            .|::..|.      .:|....|.|.|.:
Mouse   806 GPTLLKPERETGNIAVHTVYQNQIVELI 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	49/203 (24%)
Arhgap12	XP_006526377.1	SH3_ARHGAP12	13..72	CDD:213003
		SH3-WW_linker	69..264	CDD:374675	17/65 (26%)
		PRP40	257..>409	CDD:227435	22/163 (13%)
		WW	266..296	CDD:238122	5/29 (17%)
		PH_ARHGAP9-like	462..573	CDD:270053	18/113 (16%)
		RhoGAP_ARHGAP27_15_12_9	651..836	CDD:239868	49/202 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910