Protein Alignment conu and Arhgap18

DIOPT Version :9

• Sequence 1: NP_001036454.1
• Gene: conu / 3355133
• FlyBaseID: FBgn0039994
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_789807.1
• Gene: Arhgap18 / 73910
• MGIID: 1921160
• Length: 663
• Species: Mus musculus
• Alignment Length: 614
• Identity: 161/614 - (26%)
• Similarity: 274/614 - (44%)
• Gaps: 141/614 - (22%)

  Fly    10 SDDQD-FSEFLNEYYLQ------SNSQSIEPEASY-----EDGEMEAEWLVSAGYPELTKPFEQG 62
            |..|| ..|.:..|:.:      ||....|.:.:.     ::||:|.|||..||   |:..|.:.
Mouse    63 SSSQDSLDESMEAYWTELENIKRSNENRQEGQEAIVVKEPDEGELEEEWLKEAG---LSNLFGES 124

  Fly    63 LEVSKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTRSR 127
            ::..::.: ..|:||::..|.|:.:.|.|:::|:|.:.|....|  |:||:|.:..|      ::
Mouse   125 IDDPQESI-LFLSTLTRTQAAAVQKRVETVSQTLRKKNKQHHIR--DVRDIFAQQRE------AQ 180

  Fly   128 SATPDSLDSLQIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYA 192
            ...||..|   :....||           :|..........|..:..|:.:.|.|...|.|.|
Mouse   181 EKPPDDSD---LRSVRTN-----------ENKGQGKDDQPSSGAVDSKEQISRVPEDTPASET-- 229

  Fly   193 DIFRGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESRSENDARSQKKKS 257
                      ||.|               .:.|.........|     |||       |:||..|
Mouse   230 ----------DINL---------------EVSFAEQAVNQKEF-----SKE-------RTQKISS 257

  Fly   258 SEVLSASENECGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQ 322
            ::.|.:..      ||            :|.:.             :|...|   ::..|||::.
Mouse   258 NDSLPSFR------LP------------KDKTG-------------TTRIGD---LAPQDMKKVC 288

  Fly   323 TILWLELATIFDRNKVSLDKRKPFKRRRKEEGNLFGVSINALIRRDQ-QVTGTDSSLVPLFLEKL 386
            ::..:||..::|...:...::|..|.:.::.| |||:.:..|:.:|| :|.||   .:||..:||
Mouse   289 SLSLIELTALYDVLGLEFKQQKAVKIKTRDSG-LFGIPLTILLEQDQRKVPGT---RIPLIFQKL 349

  Fly   387 IGELLRRGSRE-EGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRE 450
            |.. :..||.| ||||||.|...:.:.|..|||:.||:...|.:::.:    |:.:||||.:|||
Mouse   350 ISR-IEEGSLETEGLLRIPGAAMRIKNLCQELEAKFYEGTFNWESVKQ----HDAASLLKLFLRE 409

  Fly   451 LPQPLLTNELIQLFYQCHTLPS-IDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMN 514
            ||||||:.|.::.|.....||: .:|:.||::|..|||..||:||::||.|...:|:.|:.|||.
Mouse   410 LPQPLLSMEYLKAFQAVQNLPTRKEQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMT 474

  Fly   515 VHNVATIMAPSMFPPRYIHPSD-NNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVE---- 574
            ..|||.:|||::|   ..|... .:|...:..|||....:.::||...:.|:.:|..::::
Mouse   475 AGNVAMVMAPNLF---MCHTLGLKSSEQREFEMAAGTANVMHLLIRYQKILWTIPKFIVIQVRKQ 536

  Fly   575 ----------SQKTMMGKKGWHRHRNSNE 593
                      :.|.::.|..:.|.::..:
Mouse   537 NIENQKKERKAMKKLLKKMAYDREKHEKQ 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	84/237 (35%)
Arhgap18	NP_789807.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	14..73		4/9 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	85..106		3/20 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..228		13/74 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..277		13/74 (18%)
		RhoGAP_ARHGAP18	321..534	CDD:239856	84/223 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838664
Domainoid	1	1.000	110	1.000	Domainoid score	I6305
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	187	1.000	Inparanoid score	I3900
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D309300at33208
OrthoFinder	1	1.000	-	-		FOG0002326
OrthoInspector	1	1.000	-	-		otm44275
orthoMCL	1	0.900	-	-		OOG6_108161
Panther	1	1.100	-	-	O	PTHR14963
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5254
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790