DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and Arhgap21

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_006497601.1	Gene:	Arhgap21 / 71435	MGIID:	1918685	Length:	1957	Species:	Mus musculus

Alignment Length:	662	Identity:	137/662 - (20%)
Similarity:	242/662 - (36%)	Gaps:	172/662 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LQSNSQSIEPEASYEDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTTLSKPHAEAIVQL 88
            |..:.:|:.|.:.  ||:..::       .|.:|.:::||:..::|.:     ||..|..::
Mouse   861 LSHDQESVGPPSL--DGQHSSK-------TERSKSYDEGLDDYREDAK-----LSFKHVSSL--- 908

  Fly    89 VRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTRSRSATPDSLDSLQIDEAW---------- 143
                 |.::            |.|..:..::.|    ||..:...:.|....|.|
Mouse   909 -----KGIK------------ITDSQKSSEDSG----SRKGSSSEVFSDAAREGWLQFRPLVTDK 952

  Fly   144 ---TNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRR--TPSAPPK---------SGTYAD- 193
               ...|:..:..:|         .|.:.:.:||.::.|.  |||...:         ..:|::
Mouse   953 GKRVGGSIRPWKQMY---------VVLRGHSLYLYKDRREQTTPSEEEQPISVNACLIDISYSET 1008

  Fly   194 ----IFRGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESRSENDARSQK 254
                :||.:...|:....:.|..::|.:  |.|||...|.:..|         ...:..|..|::
Mouse  1009 KRRNVFRLTTSDCECLFQAEDRDDMLSW--IKTIQESSNLNEED---------TGVTNRDLISRR 1062

  Fly   255 KKSSEVLSASENECGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLF-------TDVVL 312
            .|....|.:|:.|  :|...|...||...           .:|.....|.|..       ::..|
Mouse  1063 IKEYNSLLSSKTE--QLPKTPRQSLSIRQ-----------TLLGAKSEPKTQSPHSPKEESERKL 1114

  Fly   313 ISETDM---KRLQTILWLELATIFDRNKVSLDKRKPFKRRRKEEGNLFGVSINALIRRDQQVTGT 374
            :|:.|.   |...|  |        |..:....||.|:::....|. |||      |.|......
Mouse  1115 LSKDDTSPPKDKGT--W--------RRGIPSIVRKTFEKKPAATGT-FGV------RLDDCPPAH 1162

  Fly   375 DSSLVPLFLE---KLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTAT 436
            .:..:||.::   ||:.|   ||....|:.|:.|:......:..||.... .:.|..|:.:|...
Mouse  1163 TNRYIPLIVDICCKLVEE---RGLEYTGIYRVPGNNAAISSMQEELNKGM-ADIDIQDDKWRDLN 1223

  Fly   437 VHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPS-IDQMNALSILCHLLPPENRNTLRSLLSF 500
            |  :|||||.:.|:||:||.||:....|.:.:.... :|::..|..|.|.||..:..||:.|.:.
Mouse  1224 V--ISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLRTLKRLIHDLPEHHFETLKFLSAH 1286

  Fly   501 FNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLF 565
            ...:....:.|||...|:|.:..|::     :..|::|.......|..| .::...||...:..|
Mouse  1287 LKTVAENSEKNKMEPRNLAIVFGPTL-----VRTSEDNMTHMVTHMPDQ-YKIVETLIQHHDWFF 1345

  Fly   566 ---------------------QVPNNLIVESQKTMMGKKGWHRHRNSNEITAKPSGKASNVGVGH 609
                                 .|||   ::...|.:|:.|......|:..|:..:....:.|.|.
Mouse  1346 TEEGAEEPLTAVQEENTVDSQPVPN---IDHLLTNIGRTGVLPGDVSDSATSDSAKSKGSWGSGK 1407

  Fly   610 DSTVINKYSTNL 621
            |     :||..|
Mouse  1408 D-----QYSREL 1414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	59/244 (24%)
Arhgap21	XP_006497601.1	PDZ_signaling	55..162	CDD:238492
		PH_ARHGAP21-like	938..1047	CDD:269955	22/119 (18%)
		RhoGAP_ARHGAP21	1150..1345	CDD:239860	55/213 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910