DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and Arap1

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_006508249.1	Gene:	Arap1 / 69710	MGIID:	1916960	Length:	1452	Species:	Mus musculus

Alignment Length:	467	Identity:	100/467 - (21%)
Similarity:	170/467 - (36%)	Gaps:	150/467 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 TAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADIFRGSQVRCDIPLYSADGVELLGYSRIGTIQF 225
            |.:...||:.:....:.||...|        .::.|...|:   ||.....|.|...|..|.:.
Mouse   701 TPLALAEQAGQTLQMEFLRNNQS--------TEVPRLDSVK---PLEKHYSVTLPTVSHSGFLY- 753

  Fly   226 PRNRSVSDPFCSIGRSKESRSENDARSQK--KKSSEVLSASENECGRLLPMPYNVLSFESICRDS 288
                    ...|.|:..:.|...:..|::  ..|..|||..|||  |.:.....:.:.|.:|...
Mouse   754 --------KTASAGKPLQDRRAREEFSRRWCVLSDGVLSYYENE--RAVTPNGEIRASEIVCLAV 808

  Fly   289 SSLDSCEVLDTCDIPSTLFTD------------------VVLISET------------DMKRLQT 323
            |.||:.....|.::    :|:                  |..|::.            |.:||..
Mouse   809 SPLDTHGFEHTFEV----YTEGERLYLFGLENAELAHEWVKCIAKAFVPPLAEDLLARDFERLGR 869

  Fly   324 IL-------------WL-----ELATIFDRNKVSLDKRKPFKRRRKEEGNLFGVSINALI----- 365
            :.             |.     ||..:|...    ...:|.:.|:.:|.::.|.|.|.::
Mouse   870 LPCKAGLSLQQAQEGWFALTGSELRAVFPEG----PWEEPLQLRKLQELSIQGDSENQVLVLVER 930

  Fly   366 ---------RR----------------------DQQVTGTDSSLVPLFLEKLIGELLRRGSREEG 399
                     ||                      :||:..:|   :|:.:.:.:..:.:.|...||
Mouse   931 RRTLYIQGERRLDFMAWLGVIQKAAASLGDTLSEQQLGDSD---IPVIVYRCVDYITQCGLTSEG 992

  Fly   400 LLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTA-TVH---------ELSSLLKRWLRELPQP 454
            :.|..|...||:.|              ||:|.:.| :||         ::||.|||:||:||..
Mouse   993 IYRKCGQTSKTQRL--------------LDSLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDG 1043

  Fly   455 LLTNELIQLFYQCHTLPSIDQMNALS----ILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNV 515
            |.|......:.:...:.  |:...:|    :|.| |||.||.|:::|:|....:....|.|:||.
Mouse  1044 LFTRAQRLAWLEASEIE--DEEEKISRYRELLVH-LPPVNRATVKALISHLYCVQCFSDTNQMNT 1105

  Fly   516 HNVATIMAPSMF 527
            ||:|.:..|::|
Mouse  1106 HNLAIVFGPTLF 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	55/222 (25%)
Arap1	XP_006508249.1	SAM_Arap1,2,3	6..68	CDD:188889
		PH1_ARAP	331..422	CDD:270073
		PH2_ARAP	438..527	CDD:270074
		ArfGap_ARAP	537..652	CDD:350066
		PH3_ARAP	745..851	CDD:270076	23/120 (19%)
		PH-like	864..954	CDD:388408	14/93 (15%)
		RhoGAP_ARAP	959..1137	CDD:239850	50/179 (28%)
		RA_ARAP1	1173..1265	CDD:340746
		PH5_ARAP	1265..1404	CDD:270079
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910