DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and ARHGAP21

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_011517904.1	Gene:	ARHGAP21 / 57584	HGNCID:	23725	Length:	1992	Species:	Homo sapiens

Alignment Length:	719	Identity:	145/719 - (20%)
Similarity:	263/719 - (36%)	Gaps:	193/719 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SNTDLHHSDDQDFSEFLNEYYLQSNSQSIEPEA---SYEDGEMEAEWLVSA-------------- 50
            :||::   ...:.|.|.:.:.:||:.::.||.:   .::...:.|..::||
Human   817 NNTEM---SKPNVSLFSHAFSIQSSFRTDEPTSPSIDHDIAHIPASAVISASTSQVPSIATVPPC 878

  Fly    51 -------------------GYPEL----------TKPFEQGLEVSKKDLEPILTTLSKPHAEAIV 86
                               |.|.|          :|.:::||:..::|.:     ||..|..::
Human   879 LTTSAPLIRRQLSHDHESVGPPSLDAQPNSKTERSKSYDEGLDDYREDAK-----LSFKHVSSL- 937

  Fly    87 QLVRTLNKTVRVRTKSRP-----KRKPDIRDVFREFDEQGTVTRSRSATPDSLDSLQIDEAWTNN 146
                   |.:::....:.     .||....:||.:..::|.: ..|....|....:       ..
Human   938 -------KGIKIADSQKSSEDSGSRKDSSSEVFSDAAKEGWL-HFRPLVTDKGKRV-------GG 987

  Fly   147 SLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRR--TPSAPPK---------SGTYAD-----IF 195
            |:..:..:|         .|.:.:.:||.::.|.  |||...:         ..:|::     :|
Human   988 SIRPWKQMY---------VVLRGHSLYLYKDKREQTTPSEEEQPISVNACLIDISYSETKRKNVF 1043

  Fly   196 RGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESRSENDARSQK-KKSSE 259
            |.:...|:....:.|..::|.:  |.|||...|.:..|         ...:..|..|:: |:.:.
Human  1044 RLTTSDCECLFQAEDRDDMLAW--IKTIQESSNLNEED---------TGVTNRDLISRRIKEYNN 1097

  Fly   260 VLSASENECGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLF-------TDVVLISETD 317
            ::|.:|    :|...|...||...           .:|.....|.|..       ::..|:|:.|
Human  1098 LMSKAE----QLPKTPRQSLSIRQ-----------TLLGAKSEPKTQSPHSPKEESERKLLSKDD 1147

  Fly   318 M---KRLQTILWLELATIFDRNKVSLDKRKPFKRRRKEEGNLFGVSINALIRRDQQVTGTDSSLV 379
            .   |...|  |        |..:....||.|:::....|. |||      |.|.......:..:
Human  1148 TSPPKDKGT--W--------RKGIPSIMRKTFEKKPTATGT-FGV------RLDDCPPAHTNRYI 1195

  Fly   380 PLFLE---KLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELS 441
            ||.::   ||:.|   ||....|:.|:.|:......:..||.... .:.|..|:.:|...|  :|
Human  1196 PLIVDICCKLVEE---RGLEYTGIYRVPGNNAAISSMQEELNKGM-ADIDIQDDKWRDLNV--IS 1254

  Fly   442 SLLKRWLRELPQPLLTNELIQLFYQCHTLPS-IDQMNALSILCHLLPPENRNTLRSLLSFFNIII 505
            ||||.:.|:||:||.||:....|.:.:.... :|::..|..|.|.||..:..||:.|.:....:.
Human  1255 SLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVA 1319

  Fly   506 NLKDINKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILR---------- 560
            ...:.|||...|:|.:..|::     :..|::|.......|..| .::...||..
Human  1320 ENSEKNKMEPRNLAIVFGPTL-----VRTSEDNMTHMVTHMPDQ-YKIVETLIQHHDWFFTEEGA 1378

  Fly   561 GEKLFQVPNNLIVESQK--------TMMGKKGWHRHRNSNEITAKPSGKASNVGVGHDSTVINKY 617
            .|.|..|.....|:||.        |.:|:.|......|:..|:..:....:.|.|.|     :|
Human  1379 EEPLTTVQEESTVDSQPVPNIDHLLTNIGRTGVSPGDVSDSATSDSTKSKGSWGSGKD-----QY 1438

  Fly   618 STNL 621
            |..|
Human  1439 SREL 1442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	59/233 (25%)
ARHGAP21	XP_011517904.1	PDZ_signaling	48..155	CDD:238492
		PH_ARHGAP21-like	967..1076	CDD:269955	23/127 (18%)
		PH	968..1073	CDD:278594	22/123 (18%)
		RhoGAP_ARHGAP21	1178..1373	CDD:239860	55/213 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910