Protein Alignment conu and SRGAP1

DIOPT Version :9

• Sequence 1: NP_001036454.1
• Gene: conu / 3355133
• FlyBaseID: FBgn0039994
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_065813.1
• Gene: SRGAP1 / 57522
• HGNCID: 17382
• Length: 1085
• Species: Homo sapiens
• Alignment Length: 734
• Identity: 135/734 - (18%)
• Similarity: 230/734 - (31%)
• Gaps: 282/734 - (38%)

  Fly    67 KKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQGT--------- 122
            |||.| |:........|...|||.. .|.:..:|:.|.:...|::|.||:..|..|
Human     8 KKDKE-IIAEYESQVKEIRAQLVEQ-QKCLEQQTEMRVQLLQDLQDFFRKKAEIETEYSRNLEKL 70

  Fly   123 ----VTRSRSA-------------TP-------------DSLDSLQIDEAWTNNSLPTFVNV--- 154
                :.::||.             :|             :|.|...:.:.:.||.:..|:.:
Human    71 AERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDIYLNNVIMRFMQISED 135

  Fly   155 ----YEKNTETAIQCVEQ----SNEIYLKQNLRRTPSAPPKSGTYADIFRGSQVRCDIPLYSADG 211
                ::|:.|.|.|..|.    .||:|....            || .::....:..:..|..|:.
Human   136 STRMFKKSKEIAFQLHEDLMKVLNELYTVMK------------TY-HMYHAESISAESKLKEAEK 187

  Fly   212 VELLGYSRIGTIQF--------PRNRSVSDPFCSIGRSKESR----SENDARSQKKKSSEVLS-- 262
            .|.....|.|...|        .|..||.    .|.:.||.|    |||..:|.|.::..:|:
Human   188 QEEKQIGRSGDPVFHIRLEERHQRRSSVK----KIEKMKEKRQAKYSENKLKSIKARNEYLLTLE 248

  Fly   263 --------------------------ASENECGR-LLPMPYNV---------------------- 278
                                      ||.|...| .|...||:
Human   249 ATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLDIIENAVDNLEPRS 313

  Fly   279 ----------------LSFE-------SICRDSS----------------------SLDSCEVLD 298
                            :.||       .:|:.|:                      .:::.||..
Human   314 DKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRYQQLQSRLATLKIENEEVKK 378

  Fly   299 TCDIPSTLFTDVVLISETDMKRL---------------QTIL----------------------- 325
            |.:.......|:|.|.:.|:...               :|.|
Human   379 TTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYLSKPSIAKRRANQQETEQFYFMKL 443

  Fly   326 --WLELATIFDRNKVSLD----------------------KRKPFKRRRKE-----EGNLFGVSI 361
              :||.:.:..:.:...|                      ..||.|.|:..     ...||...:
Human   444 REYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRPPNVPPKPQKHRKSRPRSQYNTKLFNGDL 508

  Fly   362 NALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFY--QN 424
            ...::...||       :||.:|..|..:...|.:.:|:.|:.|    :::..|:::::|.  :|
Human   509 ETFVKDSGQV-------IPLIVESCIRFINLYGLQHQGIFRVSG----SQVEVNDIKNSFERGEN 562

  Fly   425 P--DNLDNLFRTATVHELSS---LLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQMNALSI--L 482
            |  |:..|       |:::|   :||.:.|.|..||...|.......|..:.::.: .||.|  |
Human   563 PLADDQSN-------HDINSVAGVLKLYFRGLENPLFPKERFNDLISCIRIDNLYE-RALHIRKL 619

  Fly   483 CHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFP-PRYIHPSDNNSIAEQVRM 546
            ...||......:|.|.:|.|.:....|.|.|:.:|:|....|::.| |         .|.:||..
Human   620 LLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMPVP---------EIQDQVSC 675

  Fly   547 AAQCCRLTNILILRGEKLF 565
            .|....:...:|:..|.:|
Human   676 QAHVNEIIKTIIIHHETIF 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	53/220 (24%)
SRGAP1	NP_065813.1	F-BAR_srGAP1	26..278	CDD:153367	51/269 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..496		4/20 (20%)
		RhoGAP_srGAP	502..689	CDD:239848	51/214 (24%)
		SH3_srGAP1-3	747..799	CDD:212888
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	808..954
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	997..1038
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1051..1085

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910