DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and ARHGAP31

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_065805.2	Gene:	ARHGAP31 / 57514	HGNCID:	29216	Length:	1444	Species:	Homo sapiens

Alignment Length:	232	Identity:	61/232 - (26%)
Similarity:	100/232 - (43%)	Gaps:	18/232 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 KRKPFKRRRKEEG--NLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIG 404
            |.|..|::.|.:|  :.||..:...:    :.:|.|   ||..| |...|.:......:|:.|:.
Human     2 KNKGAKQKLKRKGAASAFGCDLTEYL----ESSGQD---VPYVL-KSCAEFIETHGIVDGIYRLS 58

  Fly   405 GHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHT 469
            |.....:.|..|..|.  |.||....:: ...:|.:.||.|.:.||||.||||.||.:.|.:..:
Human    59 GVTSNIQRLRQEFGSD--QCPDLTREVY-LQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVS 120

  Fly   470 -LPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIH 533
             .|...|:..:..:...|||.:..||..|:.....|.:......|:..|:|.:.||::...:.|.
Human   121 HCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKEIE 185

  Fly   534 PSDNNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNN 570
            .:..|..|..:.:..|...:..||    ..:.|:.||
Human   186 ATGCNGDAAFLAVRVQQVVIEFIL----NHVDQIFNN 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	56/216 (26%)
ARHGAP31	NP_065805.2	RhoGAP_CdGAP	17..211	CDD:239849	53/208 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..427
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..631
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..893
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..1108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1211..1346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910