DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and bcr

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_002665983.2	Gene:	bcr / 568320	ZFINID:	ZDB-GENE-040724-43	Length:	1341	Species:	Danio rerio

Alignment Length:	815	Identity:	158/815 - (19%)
Similarity:	264/815 - (32%)	Gaps:	343/815 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 HHS-----DDQDFSEFLNEYYLQSNSQSIEPEASYEDGEMEAEWLVSAGYPELTKPFEQGLEVSK 67
            ||.     ||...|    ..:|.|.|:|.....|  .|.:|     |:...||  ..|:|||:.|
Zfish   520 HHDILPYIDDSPSS----SPHLSSKSRSSRDTLS--SGSIE-----SSKSAEL--DLEKGLEMRK 571

  Fly    68 KDLEPIL----TTLSKPHAEAIVQLVRTLNKTVRVRTKSRPK-----------RKPDIRDVFREF 117
            :.|..||    |.||  |.||::..::.|....   |.|:|.           :.|::.::.:||
Zfish   572 RVLSGILASEETYLS--HLEALLLPMKPLKAAA---TTSQPVLTVQQIETIFFKVPELYEIHKEF 631

  Fly   118 DEQGTVTRSRSATPDSLDSLQIDEAWTNNS---------------LPTFVNVYEKNTETAIQCVE 167
                         .|||  |...:.|:::.               ...||:.||...|||.:|.:
Zfish   632 -------------YDSL--LPRVQQWSHHQRVGDLFQKQASQLGLYRAFVDNYELAVETAEKCCQ 681

  Fly   168 QSNE----------------------------------------IYLKQNLRRTPSAPP------ 186
            .:.:                                        :.|...|:.|||:.|
Zfish   682 ANTQFAEISESLKVRSTKECKDLTAKYSLETLLYKPVDRVTRSTLVLHDLLKHTPSSHPDYPLLQ 746

  Fly   187 -----------------------------------KSGTYADIFRGSQVRCDIPLYS-----ADG 211
                                               |.|...::..|::....:.|::     |..
Zfish   747 DALRISQNFLSSINEESTPRRQSMTVKKGENRQLLKDGFMVELVEGARKLRHVFLFTDLLLCAKL 811

  Fly   212 VELLG----------YSRIGTIQFPRNRSVSDPFCSIGRSKES------------RSENDARSQK 254
            .:|:|          |..:..:.| :....|:|. .|.::.:.            |||.....:.
Zfish   812 KKLIGGKSQQYDSKWYIPLSDLTF-QTAEESEPL-PIPQAPDEELDAIKIKISSLRSEIQRERRA 874

  Fly   255 KKSSEVL-----SASENECGRLLPMP---------------------YNVLSFESICRDS----- 288
            .|.|:|:     ..||.|...||..|                     |....::.:.|:.
Zfish   875 NKGSKVMERLKKKLSEQESLFLLNSPNMPLRVHNRNGKSYMFLISSDYERAEWKEVIREQQKKCF 939

  Fly   289 -----SSLD------SCEVLDTC-DIPSTL------------FTDVVLISETDMKRLQTIL---- 325
                 ||::      ||..|.|. .:|.|:            |.:|::.|.:.:|:...:.
Zfish   940 KTFNLSSMELQMLTNSCVKLQTVHQLPLTVNKEEDESTGLYGFLNVIVHSASGLKQSLNLYCTLE 1004

  Fly   326 -----------------------W-----LEL--------------------------------- 329
                                   |     :||
Zfish  1005 VDSFGIFVNKAKTRVYRYTTEPKWNEEFEIELEGSHTLRLLCYEKSYNKAKVNKEDGESTDRIMG 1069

  Fly   330 -----------------ATIFDRN----KVSLD--------KRKPFKRRRKEEGNLFGVSINALI 365
                             .|:...|    |:|:.        ||.|   .||..| :|||:|:.:.
Zfish  1070 KGQMPLDPQMLQGKDWQRTVIPMNGIEVKISMKFTSREFSLKRMP---SRKPMG-VFGVNISTVT 1130

  Fly   366 RRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDN 430
            :|::       |.||..:.:.:.|:.|||..|.|:.|:.|  ..|::  ..|::.|..|..::..
Zfish  1131 KRER-------SKVPYIVRQCLEEIERRGMEEVGIYRVSG--VATDI--QALKTAFDTNNKDVSV 1184

  Fly   431 LFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTL-PSIDQMNALSILCHLLPPENRNTL 494
            :.....|:.::..||.:.||||:||.|:||...|.....| .|:.:.:.:..|...||..|..|.
Zfish  1185 MMSEMDVNAIAGTLKLYFRELPEPLFTDELYPNFAGGIALSDSVAKESCMLNLLLSLPEPNLVTF 1249

  Fly   495 RSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPP 529
            ..||.....|...:.:|||::||:||:..|::..|
Zfish  1250 LFLLDHLKRIAEKECVNKMSLHNLATVFGPTLLRP 1284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	52/175 (30%)
bcr	XP_002665983.2	Bcr-Abl_Oligo	3..75	CDD:286168
		RhoGEF	573..761	CDD:279015	35/207 (17%)
		PH-like	755..947	CDD:302622	27/193 (14%)
		C2_ABR	983..1103	CDD:176068	10/119 (8%)
		RhoGAP_Bcr	1122..1322	CDD:239852	52/174 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910