DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and si:dkeyp-23e4.3

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_005161485.1	Gene:	si:dkeyp-23e4.3 / 566257	ZFINID:	ZDB-GENE-091118-19	Length:	1067	Species:	Danio rerio

Alignment Length:	894	Identity:	169/894 - (18%)
Similarity:	290/894 - (32%)	Gaps:	350/894 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TDLHHSDDQDFSEFLNEYYLQSNSQSIEPEASYEDGEMEAEWLVSAGYPELTKPFEQ-----GLE 64
            |.|..|..:...:..|:.:......:.|...|..:.:...:||.:||:|:..:.|..     .::
Zfish     9 TPLRRSFSEHVKDSTNKAWDTFWKSAREKRLSEIEAKEACDWLHAAGFPQYAQLFTDCCFPIDID 73

  Fly    65 VSKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTK-SRPKRKPD------------------- 109
            ..|.|.:    .|.|...:::.:.:.||||:|.::.: ||.||:.|
Zfish    74 WVKSDYD----FLDKDALDSLCRRLSTLNKSVEMKLELSRSKRRRDEEEEEDLYAISPKWTFDRK 134

  Fly   110 IRDVFREFDEQ---------GTVTRSRSATPDSLDSLQIDE-----AWTNN-----SLPTFVNVY 155
            .|...||.|.:         ..:.||.|......|:.:..|     :.:||     |.|......
Zfish   135 SRRWIREDDGELPHTLRGPISNLRRSGSCEASLSDNGECHELCSTHSSSNNDSDGGSAPNKTTEE 199

  Fly   156 EKNTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADI-------------------------- 194
            .:.:.::.:|  .||  |..|:...:.|.||....:..:
Zfish   200 PETSRSSSRC--SSN--YKPQSPDTSSSRPPSPSEHHTLSSEEFLPEKPPLKKGKGLLRKMEKLR 260

  Fly   195 FRGS---------QVRCDI--PL----YSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKES 244
            .|||         :.|..|  |:    :..:.::.|....:.:||   |::.|...||......|
Zfish   261 LRGSTQQSQSHSGKARLVISGPIIQEGFDEETLKHLQCLDLASIQ---NKTESPASCSPPSGSSS 322

  Fly   245 RSENDA-----------RSQKKKSSEVLSASENE-----------CGRLLPMPY--------NVL 279
            .||:.:           ||..|:...:....|.|           ...:..:|:        .||
Zfish   323 TSESSSAVSTPSPVTKVRSNCKRPGVLKQEVEQEQINTQHFNNKQVNPVFKIPHGHKPGTFPTVL 387

  Fly   280 SFESI-----------------------CRDSSSLD---SC--------------------EVLD 298
            |..:.                       |:.:||.|   :|                    ::||
Zfish   388 SHNNAFLPIDNTSVNWRTGSFHGYRGRRCKSNSSKDQEQACSPLASSDHRVSFYDNVPDPVQILD 452

  Fly   299 -------------TCDI--------------------------PSTLFTDVVL----ISETD--- 317
                         .||:                          ||:| ||:.|    ..|||
Zfish   453 DDVFSALDSVMERICDLQQLVTSWTDKLSEDGDSDFSHSGSPSPSSL-TDIHLEIKEPEETDEAA 516

  Fly   318 ---------------------MKRLQTILW-----LEL------------ATIFDRNKVSL---- 340
                                 ..|:|...|     |.|            |.:....::||
Zfish   517 LEEMYNKSPEAFECTAQPTEHTDRIQRPHWSSAQMLSLSSPGTGIEAKSAAHVSMLQRLSLLRLT 581

  Fly   341 ---DKRKPFKRR----------RK------EEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKL 386
               ||..||.::          ||      :...:|.|.:.      |.|..:...|.|..|..:
Zfish   582 ALMDKHSPFSKQGWNWTVPKLYRKVKPSEHKSRKVFEVPLL------QSVQQSGKPLPPSILRAM 640

  Fly   387 IGELLRRGSREE-GLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRE 450
              |.||....:: ||.|..|.|.:.:.|.:.:|:    :||.:.  |...:..:::.::|::.|:
Zfish   641 --EFLRTKCLDQVGLFRKSGVKSRIQNLRDMVEA----DPDGVS--FENQSAFDVADMVKQYFRD 697

  Fly   451 LPQPLLTNELIQLFYQCHT-LPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMN 514
            ||:|:.:::|.:.|...:. .|...|...:....:|||.|||..|:|||.|...::...:.|:|.
Zfish   698 LPEPIFSSKLCESFLHIYQYFPKDQQFVGVQAAIYLLPDENREALQSLLLFLQEVVACVEENQMT 762

  Fly   515 VHNVATIMAPSMF---------------PPRY-IHPSDNNSIAEQV-------RMAAQCCRLTNI 556
            ..|:|..:|||:|               ..:| :...|...::|.:       .|..:|.|
Zfish   763 PTNIAVCLAPSLFHLNSFKRDRTSMRSRQRKYSLGRPDQRDLSENLAATQGLSHMVTECSR---- 823

  Fly   557 LILRGEKLFQVPNNLIVESQKTMMGKKGWHRH------RNSNEITAKPS 599
                   |||:|              |.|..|      .:|.:..|.||
Zfish   824 -------LFQIP--------------KYWETHGAGSFKEDSQQNDAVPS 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	58/244 (24%)
si:dkeyp-23e4.3	XP_005161485.1	SAM_superfamily	41..104	CDD:301707	15/66 (23%)
		RhoGAP	614..831	CDD:295372	59/255 (23%)
		START_RhoGAP	865..1060	CDD:176878
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810