DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and arhgap29a

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_693227.4	Gene:	arhgap29a / 564805	ZFINID:	ZDB-GENE-030131-9510	Length:	1344	Species:	Danio rerio

Alignment Length:	748	Identity:	158/748 - (21%)
Similarity:	266/748 - (35%)	Gaps:	215/748 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LHHSDDQDFSEFLNEYYLQSNSQSIEPEASYEDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLE 71
            :|.:|    |.......||:..|....:|......:|.|.:..||..:|.|         ::.||
Zfish   355 MHEAD----SALRKARLLQAQRQEEYEKARSSTSRVEEEQISGAGGKQLEK---------RRKLE 406

  Fly    72 PILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTRSRSATPDSLDS 136
            . ...|....|:...:|..|   .|.|:.....|.|.:|....||...|..:| .::.|.:....
Zfish   407 E-EALLKAEEAQDHYKLCVT---DVGVKRVDLAKTKSEILTQIRELVFQCDLT-LKAVTVNWFQM 466

  Fly   137 LQIDEAWTNNSLPTFVN---------VYE----------------KNTETAIQCVEQSNEIYLKQ 176
            .|...|    |||  :|         :||                ...|:....:..::...||:
Zfish   467 QQAQVA----SLP--INFQSLCENSKLYEPGLCYTEFVKSLPSDRSRVESFSFDISSTHNTGLKR 525

  Fly   177 NLRRTPSAPPKSGTYADIFRGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRS----------V 231
            .:..||:|         :...|||..|  ..|||.||  .:.:..|.:.|..||          :
Zfish   526 AVNSTPAA---------LVHLSQVSGD--FLSADEVE--SHVQARTAKMPDGRSHSTTDVQALRI 577

  Fly   232 SDPF-----CSIGRSKESRSENDARSQKKKSSEVLSASENECGRLLPMPYNVLSFESICRDSSSL 291
            ..||     .|.|....|.||:...|.:.:|.:..:||..:..|.||.          ...:.::
Zfish   578 QGPFRVWRTSSQGGGMCSDSESAGGSSESRSMDSPTASPGDFKRRLPR----------TPSTGTM 632

  Fly   292 DSCEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELATI---FDRNKVS-------LDK-RKP 345
            .|.:.||..:.||.        |:..:..:.|    |.|:.   |...::|       |.| |.|
Zfish   633 SSADDLDEREPPSP--------SDNGLSEMVT----EAASSPGPFRNTQMSKAAQTHKLRKLRAP 685

  Fly   346 FKRR----------------------------------RKEEG--NLFGVSINALIRRDQQVTGT 374
            .|.|                                  :|.:|  :||.:..       .|....
Zfish   686 SKCRECDSLVVFHGAECEECSLACHKKCLETLAIQCGHKKLQGKLHLFAIDF-------AQAAKN 743

  Fly   375 DSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHE 439
            ....:|..::|...|:..|....:|:.|:.|.|.:.|.|....|:.  ::...|.:|:    .|:
Zfish   744 SPDGIPFIIKKCTSEIENRALNIKGIYRVNGAKSRVEKLCQAFENG--KDLVELSDLY----PHD 802

  Fly   440 LSSLLKRWLRELPQPLLT----NELIQLFYQCHTLPSIDQMNA-----------LSI-------- 481
            :|::||.:||:||:||:.    |:.|.|..:..:: .:|::.|           :|:
Zfish   803 ISNVLKLYLRQLPEPLILFRYYNDFIGLAKESQSI-IVDEVEASRGCPTSDTPQISVELNRVLFK 866

  Fly   482 ---LCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQ 543
               |...|||.:..||:.|:...:.:....|.|||...|:..|..|::..||  ......|::..
Zfish   867 IKDLLRQLPPAHYKTLQFLIQHLHRVSERADENKMTSSNLGIIFGPTLIKPR--QADAEVSLSSL 929

  Fly   544 VRMAAQCCRLTNILILRGEKLFQVP-------------NNLIVESQKTMMGKKGWHRHRNSN--- 592
            |....|.. :..:||...|.:|..|             :.|.|:|:.|.. :||....|:|.
Zfish   930 VDYPYQAL-IVELLIRHYEMIFDTPLSPLPPSSPVAESSPLPVKSRFTPQ-EKGQQLSRHSKSLV 992

  Fly   593 EITAKPSGKASNVGVGHDSTVINKYSTNLKHLH 625
            :|..:...||.         :..::|:.:..:|
Zfish   993 DIKEQQQSKAK---------MYKRHSSVIPSMH 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	58/258 (22%)
arhgap29a	XP_693227.4	BAR	230..484	CDD:299863	35/152 (23%)
		C1	675..721	CDD:197519	6/45 (13%)
		RhoGAP	733..945	CDD:295372	52/228 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910