DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and arhgap22

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_690970.4	Gene:	arhgap22 / 562503	ZFINID:	ZDB-GENE-090313-87	Length:	698	Species:	Danio rerio

Alignment Length:	490	Identity:	114/490 - (23%)
Similarity:	189/490 - (38%)	Gaps:	142/490 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 LKQNLRRTPSAPPKSGTYADIFRGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCSI 238
            |...:|::..|..||....::.|||                   ||      |.:.|:.:.....
Zfish     5 LSPKIRQSRRARSKSMVMGELSRGS-------------------SR------PSSPSLQEQVVKA 44

  Fly   239 GRSKESRS----------------------ENDARSQ---KKKSSEV--LSASENECGRLLPMPY 276
            |..|:.||                      |.:.:.|   ..:.|:|  |:|:.:|.||.|
Zfish    45 GWLKKQRSIMKNWQLRWFVLRTDHLYFYKDEEETKPQGCIPLQGSQVNELTANPDEPGRHL---- 105

  Fly   277 NVLSFESI--C---RDSSSLDSCEVLDTCDIPSTLFTDVVLISETDM----KRLQTILWLELATI 332
                ||.:  |   :|.|:|.....|            ::..|:.||    |.::.::|
Zfish   106 ----FEIVPGCTGEKDRSALSHEAFL------------LMANSQNDMEDWVKAIRRVIW------ 148

  Fly   333 FDRNKVSLDKRKPFKRRRKEEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSRE 397
                       .||      .|.:||..:...::.:::.   ...|.||.:|:.:..:..:|.:|
Zfish   149 -----------APF------GGGIFGQHLEDTVQYERKF---GPRLAPLLVEQCVDFIREQGLKE 193

  Fly   398 EGLLRIGGHKQKTELLYNELESTFYQNPDNLDN-LFRTAT-VHELSSLLKRWLRELPQPLLTNEL 460
            |||.|:.|...    |..||:..|    |..|. ||.:.| ||.::||||.:|||||:|::....
Zfish   194 EGLFRMPGQAN----LVKELQDAF----DCGDKPLFDSNTDVHTVASLLKLYLRELPEPVIPFNK 250

  Fly   461 IQLFYQCHTLPSIDQMNALSIL---CHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIM 522
            .:.|..|..|...|:...|..|   ...||..|.|.|:.:..|.:.:.:..:.|||:|.|:||:.
Zfish   251 YEDFLTCAQLLLKDEEMGLGELVKQVSTLPQANYNLLKYICKFLDEVQSHSNENKMSVQNLATVF 315

  Fly   523 APSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVESQKT---MMGKKG 584
            .|::..|:...|      ...:....|..:|..:||...|:|: |.|...|.|..|   ..|::|
Zfish   316 GPNILRPKIEDP------VSMMEGTTQVQQLMTVLISEHERLY-VGNERDVSSDHTGSCPRGQRG 373

  Fly   585 WHRHRNSNE------------ITAKPSGKASNVGV 607
            .....:..|            :....||.|:::.:
Zfish   374 MVEWISDEELLNCSSPSQISKVVESVSGSATSLDI 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	65/224 (29%)
arhgap22	XP_690970.4	PH-like	39..154	CDD:302622	28/157 (18%)
		PH	41..147	CDD:278594	25/125 (20%)
		RhoGAP_ARHGAP22_24_25	154..352	CDD:239855	61/214 (29%)
		BAR	<577..>683	CDD:299863
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910