DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and arhgap25

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_005165226.1	Gene:	arhgap25 / 562468	ZFINID:	ZDB-GENE-060526-210	Length:	647	Species:	Danio rerio

Alignment Length:	414	Identity:	107/414 - (25%)
Similarity:	171/414 - (41%)	Gaps:	85/414 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 TIQFPRNRSVSD---PFCSIGRSKE----SRSENDARSQKKKSSE----------VLSASENECG 269
            :::.|||...|.   ....|.|||.    ..|.....|..|||.|          ..|..:|...
Zfish     2 SLRLPRNWDFSTFRAETAKIARSKSVIPGEGSPASTHSGFKKSMEKPLKTGWLKKQRSIVKNWQL 66

  Fly   270 RLLPMPYNVLSF-----ESICRDSSSLDSCEVLDTCDIPST-----LFTDVVLISETDMKRLQTI 324
            |...:..|.|::     ||..:.:..|.||:|   .::||.     ||..:.....||.:|...:
Zfish    67 RFFVLRGNSLTYHKDDKESTVQGTIPLFSCQV---NELPSNADDKFLFEIIPAGGSTDRERDAYV 128

  Fly   325 LWLELATIFDRNKVSLDK-----RKPFKRRRKEEGNLFGVSINALIRRDQQVTGTDSSLVPLFLE 384
            |   :||    ::..:::     ||....|   ...:||.|::.::..:::.   .:.|||:.:|
Zfish   129 L---MAT----SQSEMEEWVRWIRKAIGSR---SNGVFGKSLSDIMVYERKF---GARLVPILVE 180

  Fly   385 KLIGELLRRGSREEGLLRIGGH----KQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLK 445
            |....:...|..|||:.|:.|.    ||..|........:|   |.:.|       ||.::||||
Zfish   181 KCAEFIREHGLVEEGIFRLPGQDNQVKQFREAFDAGERPSF---PSDTD-------VHTVASLLK 235

  Fly   446 RWLRELPQPLLTNELIQLFYQCHTLPSIDQMNA-----LSILCHLLPPENRNTLRSLLSF-FNII 504
            .:|||||:|::.....|.|.....:  :|...|     |.....|||..|.|.|..:..| |.:.
Zfish   236 LYLRELPEPVVPWTQYQDFLDSTLM--LDATTAAGKEKLEKQISLLPKVNYNLLSYICRFLFEVQ 298

  Fly   505 INLKDINKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLFQVPN 569
            .|.| :|||:|.|:||:|..::|.|:.   .|..|:.:...|..   ::..::|...|.||....
Zfish   299 QNSK-VNKMSVENLATVMGVNLFKPQV---EDAISMMKGTPMIQ---KVMTVMIRHHELLFPPSK 356

  Fly   570 NLIV--------ESQKTMMGKKGW 585
            ::..        :|:||.....||
Zfish   357 DMKPSPLPSRKNKSKKTSNSFVGW 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	64/237 (27%)
arhgap25	XP_005165226.1	PH-like	46..155	CDD:302622	25/121 (21%)
		PH	48..148	CDD:278594	23/109 (21%)
		RhoGAP_ARHGAP22_24_25	154..352	CDD:239855	62/219 (28%)
		DUF3585	<556..>601	CDD:304905
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910