DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and arhgap32a

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_690921.4	Gene:	arhgap32a / 562449	ZFINID:	ZDB-GENE-060503-918	Length:	1676	Species:	Danio rerio

Alignment Length:	681	Identity:	138/681 - (20%)
Similarity:	239/681 - (35%)	Gaps:	179/681 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 HSDDQDFSEFLNEYYLQSNSQSIEP--EASYEDGEMEAEWLVSAGYPELTK-PFEQGL------- 63
            |.::.:..|          .:|::|  .|.:||    |..:::.|.|.:.: |.|..|
Zfish    32 HPEEDEGEE----------DRSLQPAETAGWED----AIAVMARGAPTVPELPAESSLRSCVSTA 82

  Fly    64 -----EVSKKDLE----PILTTLSKPHAEAI----VQLVRTLNKTVRVRTKSRPKRKPDIRDVFR 115
                 .|.|..|.    |.|...:..|.|.:    |||..|
Zfish    83 SMKVKNVKKLSLTKRHFPKLAECAHFHYENVDFGSVQLSLT------------------------ 123

  Fly   116 EFDEQGTVTRSRSATPDSLDSLQI---DEAWT-NNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQ 176
              |||..:|.:...:.:|:..:||   ...|| ..|...| .|.:|:...   |:.......|.:
Zfish   124 --DEQNDLTNNGLDSKESVYLIQICCQGRKWTVRRSYEEF-RVLDKHLHL---CIYDRRFSQLPE 182

  Fly   177 NLRRTPSAPPKSGTYADIFRGSQVRCDIPLYSADGVELLGY-SRIGTIQFPRNRSVSDP---FCS 237
             |.|..|...|:||.:.:                   |..| ||:..|  ..|:....|   :..
Zfish   183 -LPRIDSLKDKTGTLSQM-------------------LTAYISRLSAI--ADNKINCGPALTWME 225

  Fly   238 IGRSKESRSENDARSQK--------------KKSSEVLSASENECGRLLPMP------------- 275
            |.........||..|..              .::::.||....:...::.||
Zfish   226 IDNKGNHLLVNDESSINVPAVAAAHVIKRYIAQAADELSFEVGDIVSVIDMPPKEDTGWWRGKHG 290

  Fly   276 YNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELATIFDRNKVSL 340
            :.|..|.|         .|..|.:..|||.:.:.  |......|..:.|.:|.          :.
Zfish   291 FQVGFFPS---------ECVELISEKIPSNVTSS--LAKPVSKKHGKLITFLR----------TF 334

  Fly   341 DKRKPFKRRRKEEG----NLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLL 401
            .|.:|.|::.|:.|    .:||..:...:..    :|.|   ||..:.... |.:.|....:|:.
Zfish   335 MKSRPTKQKLKQRGILKERVFGCDLGEHLLN----SGHD---VPQVIRSCT-EFIERHGVVDGIY 391

  Fly   402 RIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQ 466
            |:.|.....:.|.:|.:|...  ||...:.: ...:|.:.||.|.:.||||.||||.:|.:.|..
Zfish   392 RLSGISSNIQKLRHEFDSEHV--PDLTKDTY-VQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSD 453

  Fly   467 CHTLPSIDQ-MNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPR 530
            ..:..:.|: :..:..:...|||.:..||..|:...:.:....::..|:..|:|.:.||::...:
Zfish   454 AVSAATDDERLVKVHDVIQQLPPPHYRTLEFLMRHLSRMGTYSNVTNMHCKNLAIVWAPNLLRSK 518

  Fly   531 YIHPS--DNNSIAEQVRMAAQCCR--LTNILILRGEKLFQV------------PNNLIVESQKTM 579
            .|..:  ...|...:||:.:....  |.::.:|...||..:            |.:|:|.|..|.
Zfish   519 QIESACFSGTSAFMEVRVQSVVVEFILNHVDVLFSPKLSTLIRHSTGHTTLARPKSLLVSSPSTK 583

  Fly   580 MGKKGWHRHRNSNEITA--KPSGKASNVGVG 608
            :......:.|...::.:  .|..|..:||.|
Zfish   584 LLSLEEAQARTQAQLNSPVSPDSKYIDVGEG 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	53/236 (22%)
arhgap32a	XP_690921.4	PX_domain	112..226	CDD:295365	32/165 (19%)
		SH3_ARHGAP32_33	248..301	CDD:212769	7/61 (11%)
		RhoGAP_CdGAP	353..547	CDD:239849	47/204 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910