DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and arhgap23b

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_690730.6	Gene:	arhgap23b / 562244	ZFINID:	ZDB-GENE-081031-78	Length:	1070	Species:	Danio rerio

Alignment Length:	652	Identity:	130/652 - (19%)
Similarity:	226/652 - (34%)	Gaps:	178/652 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SNTDLHHSDDQDFSEFL--------NEYYLQSNSQSIEPEASYEDGEMEAEWLVSAGYPELTKPF 59
            |..:.||....:|.:.|        :||.:...:..|.|.:..:|.             ....||
Zfish   486 SGIETHHCTSVNFIKPLSAKVLPSRSEYSVHKTNSGITPSSVEQDS-------------LAVIPF 537

  Fly    60 EQGLEVSKKD--LEPILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQGT 122
            :..|:.|::.  :..|.|..||...|.:    .|..:..||..| .|||   ::..|
Zfish   538 KGSLKKSRRSSYMLAITTERSKSCDEGL----NTFREEERVLLK-LPKR---VKSFF-------- 586

  Fly   123 VTRSRSATPDSLDSLQIDE-----------------------AWTNNSLPTFVNVYEKNTETAIQ 164
                   |.|||:||::.|                       .|.:  ....:|...|...:.::
Zfish   587 -------TDDSLESLKVAEDAHSKRHSTSELGNINLTDIRKQGWLH--YKQILNDKRKKVGSGMR 642

  Fly   165 ------CVEQSNEIYLKQNLRRTPSAPPKSGTYADIFRGSQVRCDIPLYSADGVEL-LGYSRIGT 222
                  .|..|:.::|.::.|.......::|::     |.....||...|..|..: :.||.  |
Zfish   643 QWKRVFSVLHSSLLFLYKDKREAVLHATRAGSH-----GIGQEKDIQTISIQGCLIDIAYSE--T 700

  Fly   223 IQFPRNRSVSDPFCSIGRSKESRSENDARSQKKKSSEVLSASENECGRLLPMPYNVLSFESICRD 287
            .:....|.::..||......|.|.:                              :|.:..:.|:
Zfish   701 KRKHTFRLMTQDFCEYLLQAEDRDD------------------------------MLMWIRVIRE 735

  Fly   288 SSSLDSCEVLDTCDIPSTLFTDVVLIS----------------ETDMKRLQTILWLELATIFDRN 336
            .|..::.|:         .|:..||||                :|..|..|.:....|:...:.:
Zfish   736 KSKTENEEL---------GFSRQVLISKKLNDYKKQSPTSNKPDTSPKMHQMMPPFFLSKTENAS 791

  Fly   337 KVSLDKRKP-----------FKRRRKEEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGEL 390
            .||....|.           .|:.:|.....|||      |.:..:....:..||..:|.....:
Zfish   792 AVSKAPGKDESIRAAWGINIKKKGKKMSPKTFGV------RLEDCLPAASNKFVPQIVETCCSLV 850

  Fly   391 LRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPL 455
            ...|....|:.|:.|:......|..:|:....  .|..:..::...|  :|||||.:.|:||:||
Zfish   851 EEMGLEYTGIYRVPGNNVMVSSLQEQLDKGMV--IDTAEERWKDLNV--ISSLLKSFFRKLPEPL 911

  Fly   456 LTNELIQLFYQCHTLPSI-DQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVA 519
            .|::....|...:.|... |::..:..|...||..|.:||:.|:.....:.:..:.|||...|:|
Zfish   912 FTDDKYNDFIDANRLEDTGDRLKTMRKLIRDLPDHNYHTLKFLIGHLKTVADHSEKNKMEPRNLA 976

  Fly   520 TIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLF-------QVPNNLIVESQK 577
            .:..|::     :..|::|.| |.|...|...::|..|||.....|       :.|.:   :.||
Zfish   977 LVFGPTL-----VRTSEDNMI-EMVTHMADRYKITETLILHHTWFFSDDLDTDKTPED---QKQK 1032

  Fly   578 TM 579
            .|
Zfish  1033 EM 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	54/227 (24%)
arhgap23b	XP_690730.6	PDZ_signaling	29..136	CDD:238492
		PH	618..735	CDD:278594	22/155 (14%)
		PH_ARHGAP21-like	619..740	CDD:269955	24/159 (15%)
		RhoGAP	822..1016	CDD:295372	52/209 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910