DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and myo9ab

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_021326243.1	Gene:	myo9ab / 562199	ZFINID:	ZDB-GENE-080424-6	Length:	2343	Species:	Danio rerio

Alignment Length:	687	Identity:	139/687 - (20%)
Similarity:	232/687 - (33%)	Gaps:	223/687 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 PILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTRSR-------SA 129
            |:|:....||:.:                      .|||..||....|..:....:       |.
Zfish  1500 PVLSCTRPPHSPS----------------------SPDIDCVFHSDSEMSSQKEQKRIQKTMSSG 1542

  Fly   130 TPDSLDSLQIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADI 194
            ....:|||:...:.|::.:...:..:.|:.....:...:......:...||..| ||.|..:|.:
Zfish  1543 DLGKMDSLRKSMSQTDSRVRGKMRFWSKSKHGDKKISSRGRSADSELTDRRNDS-PPGSPEHAGV 1606

  Fly   195 FRGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSV-------------SDPFCSIGRSKESRS 246
               |:.|.|    |.:..|.:    :|.:...|.||:             :|....:..:.:.||
Zfish  1607 ---SERRRD----SKENREPM----LGMMSMKRRRSLKISSVSLESTAWQNDALHILTSTADYRS 1660

  Fly   247 ENDARSQKKKSSEVLSASENECGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVV 311
            .||  ...||.|: |.|.:.:....:.:.:.....|......:|..:...:|  |..|..:.|:.
Zfish  1661 MND--FLMKKISD-LDAEDGQKDTAVDVVFKKALKEFRLNIFNSYSTALAMD--DGRSIRYKDLY 1720

  Fly   312 LISETDMK---RLQTILWLE--LATIFDRNKVSLD----KRKPF------------KRRRKEEGN 355
            .:.|..::   ||:...|.|  :....:..||.||    :.||.            |:|||:|.:
Zfish  1721 ALFEHILEKSMRLEQRDWSESPVKVWVNTFKVFLDEFMTEYKPMDGTISKAPKPERKKRRKKESD 1785

  Fly   356 L---------------------------------------------------------------- 356
            .
Zfish  1786 TVEEHMGHIFKSTQYSIPTYCEFCSSLIWMMDKACVCKLCRYACHKKCCLRMTTKCSKKFDPELS 1850

  Fly   357 ---FGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELE 418
               |||.::.|.        :|...|||.:||||..:...|...||:.|..|...|.:.|...|:
Zfish  1851 SRQFGVELSRLT--------SDERSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELKQGLD 1907

  Fly   419 STFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPS----------- 472
            :.  .|..|||:.    .:|.::|:||:|||:||.||:|.||.:.|.:...|..
Zfish  1908 TD--ANSVNLDDY----NIHVIASVLKQWLRDLPNPLMTFELYEEFLRAMGLQDKREVVQGVYSI 1966

  Fly   473 IDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSDN 537
            |||::.    .||      |||..|:.....|...::.|:|:.:.:|.:.||.:     :...|.
Zfish  1967 IDQLSR----THL------NTLERLIFHLVRISFQEETNRMSANALAIVFAPCI-----LRCPDT 2016

  Fly   538 NSIAEQVRMAAQCCRLTNILILRGEKLFQVP----NNL-------------IVESQKTMM----- 580
            ....:.||..::......::|....:.::..    |.|             |..|.|.::
Zfish  2017 TDPLQSVRDISKTTACVELIICEQMRKYKARLKDINTLEFAENKAKSRLTHIRRSMKPVLIAVRF 2081

  Fly   581 ------------GKKGWHRHRNSNEITAKP--SGKAS 603
                        .|||..|.|.|...|..|  |.:||
Zfish  2082 IGISRTVTSPNAAKKGKSRARKSGHHTPSPPLSPRAS 2118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	62/314 (20%)
myo9ab	XP_021326243.1	UBQ	7..111	CDD:320785
		MYSc_Myo9	163..991	CDD:276836
		C1	1793..1841	CDD:237996	0/47 (0%)
		RhoGAP_myosin_IXA	1854..2039	CDD:239871	59/213 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910