DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and srgap3

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_005166172.1	Gene:	srgap3 / 561567	ZFINID:	ZDB-GENE-060524-4	Length:	1094	Species:	Danio rerio

Alignment Length:	745	Identity:	129/745 - (17%)
Similarity:	240/745 - (32%)	Gaps:	269/745 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 EDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTKS 102
            :|.|:.||      |....|.....|....|.||        ..:||.:||::.|.:..|
Zfish     9 KDKEIIAE------YETQVKEIRNQLVEQFKCLE--------QQSEARIQLLQDLQEFFR----- 54

  Fly   103 RPKRKPDIR-DVFREFDEQGTVTRSRSATP----------------------DSLDSLQIDEAWT 144
               ||.:|: :..|..::......|:...|                      :|.|...:::.:.
Zfish    55 ---RKAEIQLEYSRSLEKLAERFSSKIRGPRKEQHLLSSVNCWYLVLNQTRRESRDHATLNDIYI 116

  Fly   145 NNSL-------PTFVNVYEKNTETAIQCVEQ----SNEIYLKQNLRRTPSAPPKSGTYADIFRGS 198
            ||.:       ...:.:::|:.|..||..|:    :||:|....            || .::...
Zfish   117 NNVIVRLAQISEDVIRLFKKSKEIGIQMHEELVKVTNELYTVMK------------TY-HMYHTE 168

  Fly   199 QVRCDIPLYSADGVELLGYSRIGTIQF--------PRNRSVSDPFCSIGRSKESR----SENDAR 251
            .:..:..|..|:..|...:|:.|.:..        |:.||   ....|.:.||.|    |||..:
Zfish   169 SISAESKLKDAEKQEEKQFSKSGDLNVNLLRHEDRPQRRS---SVRKIEKMKEKRQAKYSENKLK 230

  Fly   252 SQKKKSSEVLS-ASEN---------------ECGRL-------------LPMPYNV--------- 278
            ..|.::..:|: |:.|               :|..|             |...||:
Zfish   231 CTKARNDYLLNLAATNAVVAKYYIHDVSDMIDCCDLGYHASLARTLRTYLSAEYNLETSRHEGLD 295

  Fly   279 -----------------------------LSFE-------SICRDSS------------------ 289
                                         :.||       .:|:.|:
Zfish   296 IIENAVDNLDPRSDKHKIMDMYNQVFCPPMRFEFLPHMGDEVCQVSAQQPVQTELLMRFHQLQSR 360

  Fly   290 ----SLDSCEVLDTCDIPSTLFTDVVLI----------------------SETDMKRLQ------ 322
                .:::.||..|.|.......|::.:                      ||:.|.:|.
Zfish   361 LATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESIKSVASESYMSKLNIAKRRA 425

  Fly   323 -------------------TILWLELATIFDRNKVSLDK---------------------RKPFK 347
                               :.|.::|....|..|.:|.:                     ||| :
Zfish   426 NQQETEVFYFTKFKEYLNGSNLIIKLQAKHDLLKQTLGEGERAECGTTRPPTLPPKPQKLRKP-R 489

  Fly   348 RRRKEEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTEL 412
            .|......||..::.:.|:...|.       :||.:|..|..:...|.:::|:.|:.|    :::
Zfish   490 PRSVYNHKLFNGNMESFIKDSGQA-------IPLVVESCIRYINLYGLQQQGIFRVPG----SQV 543

  Fly   413 LYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNE-LIQLFYQCHTLPSIDQM 476
            ..|:::::|.:..|.|.:......::.::.:||.:.|.|..||...| .:.:........|.::.
Zfish   544 EVNDIKNSFERGEDPLVDDQSDHDINSVAGVLKLYFRGLENPLFPKERFLDMISTVKLESSAERA 608

  Fly   477 NALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSDNNSIA 541
            :.:..:...||......||.|.:|.|.:....|.|.|:.:|:|....|::.|    .|...:.:|
Zfish   609 HHIQQIIVTLPRTVIIVLRYLFAFLNHLSQYSDENMMDPYNLAICFGPTLMP----IPDGQDPVA 669

  Fly   542 EQVRMAAQCCRLTNILILRGEKLFQVPNNL 571
            .|    |....:...:|:..|.:|..|..|
Zfish   670 CQ----AHVNEVIKTIIMHNEIIFPSPREL 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	47/217 (22%)
srgap3	XP_005166172.1	BAR	26..273	CDD:299863	51/278 (18%)
		RhoGAP_srGAP	497..684	CDD:239848	43/205 (21%)
		SH3_srGAP1-3	741..793	CDD:212888
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910