DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and stard8

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001119949.1	Gene:	stard8 / 558476	ZFINID:	ZDB-GENE-030131-9447	Length:	1076	Species:	Danio rerio

Alignment Length:	677	Identity:	150/677 - (22%)
Similarity:	263/677 - (38%)	Gaps:	209/677 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 VSKKDLEPILTTLSKPHAEAI----VQLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQ-GTVT 124
            ||:|      .||.|||...:    .||...:.|:.   :.:..:||.| |.|...||.: ||..
Zfish   312 VSQK------VTLHKPHRACLYLEDYQLTWEIPKST---SHNNRQRKED-RVVHLPFDHKPGTFP 366

  Fly   125 RSR----------SATPDSLD------SLQIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIY 173
            :|.          |.:||.:|      .|.:|.:.:.:....|::.:.:...:    :.....||
Zfish   367 KSLSIESLCPVSVSESPDHIDWAGVDGDLSLDGSVSRSGSQDFLSGFGQRRNS----ISSLGSIY 427

  Fly   174 LKQNLRRTPSAPPKSGTYADIFRGSQVR----CDIPLYSADGVE--LLGYSRIGTIQFPRNRS-- 230
              .|:..||.:|      .|||...:.:    .|..|....|::  :..:||...|| |:::|
Zfish   428 --DNVPETPGSP------GDIFDPGKKKVFQHLDDILQHVHGLQHNIEEWSRSLGIQ-PQDQSNA 483

  Fly   231 ---------------------------VSDPFCSIGRS-KESRSENDARSQKKKSSEVLSASENE 267
                                       ||| :.|.|.| .|...|.:.|.::          ::.
Zfish   484 ETVSTADTTLPSSLNYDEQSMSDVGTTVSD-YDSAGNSVNEGEGEGEMRERR----------DSG 537

  Fly   268 CGRLLPMPYNVL---SFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLEL 329
            .|..|..|...|   ||::..|.|.|..|.|:...              |...:..||....|.|
Zfish   538 VGASLTRPSRKLRWHSFQNSHRPSVSSASLEINRQ--------------SAAQLNLLQKFSLLRL 588

  Fly   330 ATIFDRNKVSLDKRK--------PFKRRRK----EEGNLFGVSINALIRRDQQVTGTDSSLVPLF 382
            ..|.:::   .|..|        .|.:|.|    ::.::|||.....::|..|.       :|..
Zfish   589 TAILEKH---TDTSKHGWNWVVPKFMKRSKVPDYKDKHVFGVPPIVNVQRTGQP-------LPQS 643

  Fly   383 LEKLIGELLRRGSREEGLLRIGGHKQKTELL--YNELESTFYQNPDNLDNLFRTATVHELSSLLK 445
            :::.:..|..:...:.|:.|..|.|.:.:.|  .||      .:||::  .::..:.::::.|:|
Zfish   644 IQQAMRYLRSQCLEKVGIFRKSGVKSRIQALRQLNE------NSPDHV--TYQGQSAYDVADLIK 700

  Fly   446 RWLRELPQPLLTNELIQLFYQCHT-LPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKD 509
            ::.|:||:|:||::|...|...:. :|:..::.|:.....|||.|||..|::||.|.:.|.:.::
Zfish   701 QYFRDLPEPVLTSKLTDTFLHVYQFVPAEQRLQAVQAAVILLPDENREVLQTLLYFLSDIASAQE 765

  Fly   510 INKMNVHNVATIMAPSMF----------PPRYIH-----PSDNNSIAEQVRMAAQCCRLTNILIL 559
             |:|...::|..:|||:.          .||.|.     ..|:..::|  .|||..|  .:.:|.
Zfish   766 -NQMTADSLAVCLAPSILHLNASKKDGASPRLISRKGGAKPDHKDLSE--NMAATHC--LSHMIT 825

  Fly   560 RGEKLFQVPNNLIVESQKTMMG----------------------------------------KKG 584
            ..:||||:|:.::::|:.:.:.                                        .||
Zfish   826 ECKKLFQIPHEMMLQSRNSYVAADAQPLPLHGLGVNALGEPVDYRAYLEDNVQCLLREASERSKG 890

  Fly   585 WHR-HRNSN-EITAKPSGKASNVGVGH 609
            ||. |...| |:..|      .||.||
Zfish   891 WHHAHGPDNTELAYK------KVGDGH 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	60/237 (25%)
stard8	NP_001119949.1	SAM_DLC1,2-like	43..102	CDD:188937
		RhoGAP_DLC1	621..837	CDD:239840	60/235 (26%)
		START_STARD8-like	863..1067	CDD:176916	12/55 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810