DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and ARHGAP15

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_060930.3	Gene:	ARHGAP15 / 55843	HGNCID:	21030	Length:	475	Species:	Homo sapiens

Alignment Length:	331	Identity:	76/331 - (22%)
Similarity:	143/331 - (43%)	Gaps:	59/331 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   251 RSQKKKSSEVLSASENECGRLLPMPYNVL--------SFESICRDSSSLDSC--EVLDTCDIPST 305
            :|.:|...::.:.|.||......:.:.:|        :.:.:.:||    ||  ..|:...|..:
Human   150 KSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPKDS----SCPSRNLELFKIQRS 210

  Fly   306 LFTDVVLISETDMKR--------LQTILWLELATIFDRNKVS--LDK---RKPFKRRRKEEG--- 354
            ..|:::...::|:|.        |...|....:...|:|:|.  |.|   |:|..:..:|:|
Human   211 SSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIK 275

  Fly   355 -NLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHK---QKTELLYN 415
             .:||..::.:..|       ::|.||.|:::.|..:.:||...:|:.|:.|:.   ||...:.|
Human   276 DQIFGSHLHKVCER-------ENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVN 333

  Fly   416 ELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSID---QMN 477
            :.|..      |||: .:...:|.::..||.:.||||:||......:.|.:  .:...|   ::.
Human   334 QEEKL------NLDD-SQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVE--AIKKQDNNTRIE 389

  Fly   478 ALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPR------YIHPSD 536
            |:..|...|||.||:|::.|......|:.....|.|:..::..:..|::....      .||...
Human   390 AVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVY 454

  Fly   537 NNSIAE 542
            .|.|||
Human   455 QNQIAE 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	50/199 (25%)
ARHGAP15	NP_060930.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		PH	80..188	CDD:278594	6/37 (16%)
		PH_ARHGAP9-like	81..190	CDD:270053	6/39 (15%)
		RhoGAP_ARHGAP27_15_12_9	279..465	CDD:239868	50/198 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910