DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and stard13a

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_683100.5	Gene:	stard13a / 555484	ZFINID:	ZDB-GENE-091116-18	Length:	1138	Species:	Danio rerio

Alignment Length:	785	Identity:	151/785 - (19%)
Similarity:	275/785 - (35%)	Gaps:	258/785 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SDDQDFSEFLNEYYLQSNSQSIEPEASYEDGEMEAEWLVSAGYPELTKPFE--QGLEVSKKDLEP 72
            ||::|.....|.:..:.||:.   .:..:|    .::|:  |..|...|.|  :||..:... |.
Zfish   158 SDEEDLLAISNRWTFEWNSRR---WSRLQD----IDYLL--GRAEERSPSEVGEGLRTTVSS-ES 212

  Fly    73 ILTTLSKP-----HAE------------AIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQ 120
            |||.||:|     |:|            ..:.|.|.|.....:..|||.:.:...:|..|..:..
Zfish   213 ILTDLSEPEICSLHSEDSLAAMPDSASLTPLHLPRELPHYGSLPAKSRRRGRTRAKDFLRRMETL 277

  Fly   121 G-----TVTRSR-----------SATPDSLDSLQIDEAWTNNSLPTFVNVYEKNTETA------I 163
            |     ::.||.           .:.|::|.:|:..:.:  |..|    :..:||..|      :
Zfish   278 GRTWGPSMGRSERRSLVISSPVLQSEPEALKTLRCVQIF--NGAP----INAENTPPADNLPNSL 336

  Fly   164 QCVEQSNEIYLKQNLRRTPS--------APP--KSGTY---ADIFRGSQVRCDIPLYSADGVELL 215
            ...|.|::.....:...||:        .||  ::|.|   .|:..|:..| ..|:..:...|..
Zfish   337 PSSEASSQSETSGSAGSTPNNAGRLSKLYPPGKRAGVYLEDIDVLAGAPQR-RRPVEQSRKNEFR 400

  Fly   216 GYSRI----------GTIQFPRNRSVS-------------------DPF-CSIGRSKESR----- 245
            .|..:          ||  ||:..|:.                   .|| |.....:|.|
Zfish   401 SYDELLVHIPKDHKPGT--FPKALSIESLTLANKEHGNWKVLDSEPQPFKCRKVGGREVRPVTRC 463

  Fly   246 --------------------SENDARSQKKK-----------------------SSEVLSASENE 267
                                |..|....:|:                       |..||..||.|
Zfish   464 CPRGSRISVYDNVPGSHLYASTGDLLDLEKEDIFPHLDDILQHVNGLQQIVDHWSKNVLPESEGE 528

  Fly   268 CGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETD--------------- 317
            ..........::..:|..:.:...:...|::....||....|.|.:::||
Zfish   529 GDGGRGQDKRMIDGQSSSQITLDFEGTSVIEGLTTPSDGNRDGVSLNDTDTSSTRERRDSGVGAS 593

  Fly   318 ---------------------------------MKRLQTILWLELATIFDRNKVSLDKR------ 343
                                             :..||....|.|..|.::..:| :|.
Zfish   594 LTRPRLRWPSFRMSNLLSQSGISLQISSQSVGQLSLLQKFSLLRLTAIMEKYSMS-NKHGWTWSV 657

  Fly   344 KPFKRRRK----EEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIG 404
            ..|.:|.|    ::..:|||.:...::|       ....:|:.|:..:..|..:...:.||.|..
Zfish   658 PKFMKRIKGPDYKDKTVFGVPLIVHVQR-------YGHPLPMCLQLALRFLRSQCLDQVGLFRKS 715

  Fly   405 GHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHT 469
            |.|.:.:.|....|:    :|:|::  :...:.::::.::|::.|:||:||||:::.:.|...:.
Zfish   716 GVKSRIQALRQMCET----SPENVN--YDDQSAYDVADMVKQFFRDLPEPLLTSKMGETFLHIYQ 774

  Fly   470 -LPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMF------ 527
             :|...::.|:.....|:..|||..|::||.|.|.:.:..:.|:|...|:|..:|||:|
Zfish   775 YVPKEQRLQAVQAAIMLMADENREVLQTLLCFLNDVTSSVEENQMTPMNLAVCLAPSLFHLNIMK 839

  Fly   528 ----PPRYIHPS-----------DNNSIAEQ--VRMAAQCCRLTNILILRGEKLFQVPNNLIVES 575
                .||.|...           :.|..|.|  ..|.|:|           ..||::|..::.:|
Zfish   840 NDNLSPRSIQRKYATGRPDQKDLNENLAATQGLAHMIAEC-----------NHLFEIPQEMVSQS 893

  Fly   576 QKTMM 580
            :.:.|
Zfish   894 RNSYM 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	56/243 (23%)
stard13a	XP_683100.5	SAM_DLC2	82..145	CDD:188991
		SAM	86..145	CDD:197735
		RhoGAP_DLC1	671..889	CDD:239840	56/241 (23%)
		SRPBCC	929..1129	CDD:301327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810