DRSC/TRiP Functional Genomics Resources

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Protein Alignment conu and Arhgap40

DIOPT Version :10

Sequence 1:NP_001036454.1 Gene:conu / 3355133 FlyBaseID:FBgn0039994 Length:629 Species:Drosophila melanogaster
Sequence 2:NP_001138487.1 Gene:Arhgap40 / 545481 MGIID:3649852 Length:672 Species:Mus musculus


Alignment Length:654 Identity:156/654 - (23%)
Similarity:252/654 - (38%) Gaps:175/654 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 QDFSEFLNEYYLQSNSQSIEPEASYEDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTTL 77
            |..:|...|...:..||.:|       |:.|::||...|...|....  ||:   .|.:.:|:||
Mouse    91 QQRAEVKKEDCGEGRSQLLE-------GDTESQWLQDTGLSGLAGGL--GLD---GDHQGLLSTL 143

  Fly    78 SKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTRSRSATPDSLDSLQIDEA 142
            ::....|:.:.:....::.|.|.|: |.|  |:||:|      |..|....|..:.:..::    
Mouse   144 TQTQVAAVCRRLDIYARSARRRQKA-PVR--DVRDIF------GVFTSRELAPENGVSGMK---- 195

  Fly   143 WTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADIFRGSQVRCDIPLY 207
            ||        .:..:::.:.::..|              |..|.:.....::|.....      |
Mouse   196 WT--------KINSEDSASPLRSAE--------------PGGPQELAGMEEVFNMDSA------Y 232

  Fly   208 SADGVELL--------GYSRIGTIQFPRNRSVSDPFCSIGRSKESRSENDARSQKKKSSEVLSAS 264
            |.....||        |.:..|....||.|...                                
Mouse   233 SEQAAVLLQRAWPSPGGTTAWGKGPLPRFRIPK-------------------------------- 265

  Fly   265 ENECGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLEL 329
                |||           .:.|...                       :|..|||::..:..:||
Mouse   266 ----GRL-----------GVTRIGD-----------------------LSSRDMKKIPPLALIEL 292

  Fly   330 ATIFDRNKVSLDKRKPFKRRRKEEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRG 394
            ..::|...:.|.:.|..|.:..:.| ||||.:::|:..|.:|  ..|:.|||.|:.|:..|.:||
Mouse   293 TALYDILGLDLKRCKGGKWKGPDSG-LFGVPLHSLLEADHRV--FPSTQVPLLLQALLSCLEKRG 354

  Fly   395 SREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVH--ELSSLLKRWLRELPQPLLT 457
            ...||:||:.|.:.:.:.|..:||..||....:.|.      ||  :.|.||||:||:||.||||
Mouse   355 LDTEGILRVPGSQARVKGLEQKLERDFYAGLVSWDK------VHPNDASDLLKRFLRKLPVPLLT 413

  Fly   458 NELIQLFYQCHTLPSIDQ-MNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATI 521
            .|.:..|.....:|.:.| :.||.:|..|||..|||||::||.|...:...:..|||.:.||:|:
Mouse   414 AEYLPAFASVPDIPDLKQRLQALHLLVLLLPEPNRNTLKALLEFLRKVAAQEQHNKMTLWNVSTV 478

  Fly   522 MAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVE-----------S 575
            |.||:|.||...|.......:....||:   :..:::...:.|:.|.:.|:.:           |
Mouse   479 MVPSLFLPRGRPPKLTKGGKQLAEGAAE---VVCMMVQYQDLLWTVASFLVAQVRKLNDSNGRRS 540

  Fly   576 QKTMMGKKGW----HRHRNSN----EITAK----------PSGKASNVGVGHDSTVINKYSTNLK 622
            |....|.|.|    |..|:..    |.|.|          ||.....|.:...:.|.:......:
Mouse   541 QLCDGGLKTWLWRTHVDRDKAGEGLEATPKVAKIQVQATWPSMDLLQVPLNPSTRVTHVLKLFTE 605

  Fly   623 HLHP 626
            ||:|
Mouse   606 HLNP 609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
conuNP_001036454.1 RhoGAP_ARHGAP18 356..576 CDD:239856 78/233 (33%)
Arhgap40NP_001138487.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 43..68
RhoGAP 318..530 CDD:470621 78/222 (35%)
Blue background indicates that the domain is not in the aligned region.

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