DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and GMIP

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_057657.2	Gene:	GMIP / 51291	HGNCID:	24852	Length:	970	Species:	Homo sapiens

Alignment Length:	385	Identity:	87/385 - (22%)
Similarity:	141/385 - (36%)	Gaps:	108/385 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 SIGRSKESRSEND--------ARSQKKKSSEVLSASEN------------ECGRLLPMPYNVLSF 281
            |:|...||||.:.        .|...|.||....:|::            |.|  |..|:...:.
Human   425 SVGGGSESRSLDSPTSSPGAGTRQLVKASSTGTESSDDFEERDPDLGDGLENG--LGSPFGKWTL 487

  Fly   282 ESIC--------RDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKR---------LQTILWLEL 329
            .|..        |..:....||..              ::|.|:.:.         |:|:|.|
Human   488 SSAAQTHQLRRLRGPAKCRECEAF--------------MVSGTECEECFLTCHKRCLETLLIL-- 536

  Fly   330 ATIFDRNKVSLDKRKPFKRRRKEEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRG 394
                 .....|..|.|          ||||....|.|...:.       ||..:.|...|:..|.
Human   537 -----CGHRRLPARTP----------LFGVDFLQLPRDFPEE-------VPFVVTKCTAEIEHRA 579

  Fly   395 SREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNE 459
            ...:|:.|:.|.:.:.|.|...     ::|...|..|...:. |::||:|||:|:||.:|::...
Human   580 LDVQGIYRVSGSRVRVERLCQA-----FENGRALVELSGNSP-HDVSSVLKRFLQELTEPVIPFH 638

  Fly   460 LIQLFYQ-CHTL------------PSIDQMNALSILCHLLPPENRNTLRSLLS-FFNIIINLKDI 510
            |...|.. ..||            ||.:.:.:|..|...||..|.||||.|:: .|.:.....:
Human   639 LYDAFISLAKTLHADPGDDPGTPSPSPEVIRSLKTLLVQLPDSNYNTLRHLVAHLFRVAARFME- 702

  Fly   511 NKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQVRM-----AAQCCRLTNILILRGEKLF 565
            |||:.:|:..:..|::     :.|.|....|..:.:     :....:|...||:..|::|
Human   703 NKMSANNLGIVFGPTL-----LRPPDGPRAASAIPVTCLLDSGHQAQLVEFLIVHYEQIF 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	59/229 (26%)
GMIP	NP_057657.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..76
		BAR	93..164	CDD:325158
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..263
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..478		13/54 (24%)
		C1	492..537	CDD:197519	9/65 (14%)
		RhoGAP_GMIP_PARG1	549..752	CDD:239843	56/221 (25%)
		Marek_A	760..>874	CDD:332932
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..878
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..932
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910