DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and Dlc1

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001181869.1	Gene:	Dlc1 / 50768	MGIID:	1354949	Length:	1543	Species:	Mus musculus

Alignment Length:	950	Identity:	179/950 - (18%)
Similarity:	300/950 - (31%)	Gaps:	405/950 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SDDQDFSEFLNEYYLQSNSQSIEPEAS-------------------YEDGEMEA----EWLVSAG 51
            |:.:..|..:|:..:..:|:|.:|.::                   .|..|:||    :||...|
Mouse   414 SESRTDSMAVNQTQVNLSSESTDPSSTPGSNSGTKPKAMAAPCVGEKEMAEIEAKEACDWLRVTG 478

  Fly    52 YPELTKPFEQ-----GLEVSKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPD-- 109
            :|:..:.:|.     .:.:.|::.:    .|.:...||:.:.:.||||...::.:..|.||..
Mouse   479 FPQYAQLYEDLLFPIDIALVKREHD----FLDRDAIEALCRRLNTLNKCAVMKLEISPHRKRSED 539

  Fly   110 ---------------IRDVFR-----EFDE--------QGTVTRSRSATPDSLDSLQID------ 140
                           .||..|     |||.        .|:...||..:..|.:|:..|
Mouse   540 SDEDEPCAISGKWTFQRDSKRWSRLEEFDVFSPKQDPIPGSPDNSRLQSATSHESMLTDLSEHQE 604

  Fly   141 ------EAWTNNSLPT------------------------FV----------------------- 152
                  .:.|::|:||                        ||
Mouse   605 VASVRSLSSTSSSVPTHAAHSGDATTPRTNSVISVCSSGHFVGNDDSFSSLPSPKELSSFSFSMK 669

  Fly   153 NVYEKNTET-----------------------------------------------AIQCVEQS- 169
            ..:||||::                                               .:.|||.|
Mouse   670 GHHEKNTKSKTRSLLKRMESLKLKGSHHSKHKAPSKLGLIISAPILQEGMDEAKLKQLNCVEISA 734

  Fly   170 ---NEIYLK-------QNLRRTPSAPPKSGTYADIFRGSQV-------RCD--IPLYSADGVELL 215
               |.|.:.       .|..:|.|:..:|.|.:.:...|.|       .|:  :.:| .:|.:..
Mouse   735 LNGNHINVPMVRKRSVSNSTQTSSSSSQSETSSAVSTPSPVTRTRSLSTCNKRVGMY-LEGFDPF 798

  Fly   216 GYSRIGTI--------------------------QFPRNRSVSDPFCSIGRSKES---------- 244
            ..|.:..:                          .||:..| ...||..|.|..:
Mouse   799 SQSTLNNVTEQNYKNRESYPEDTVFYIPEDHKPGTFPKALS-HGSFCPSGNSSVNWRTGSFHGPG 862

  Fly   245 ----RSENDARSQK----KKSSEVLSAS----ENECGRLL--------------------PMPYN 277
                |.||...|.|    :.||..||:.    :|..|.:|                    .:.|:
Mouse   863 HLSLRRENSHDSPKELKRRNSSSSLSSRLSIYDNVPGSILYSSSGELADLENEDIFPELDDILYH 927

  Fly   278 VLSFESI-----------------------C---------------RDSSSLDSC-----EVLDT 299
            |...:.|                       |               |..|.|||.     |..:.
Mouse   928 VKGMQRIVNQWSEKFSDEGDSDSALDSVSPCPSSPKQIHLDVDHDRRTPSDLDSTGNSLNEPEEP 992

  Fly   300 CDIP--------------------------------STLFTDVVLISETDMKRLQTILWLELATI 332
            .|||                                :::...:...|...|..||....|:|..:
Mouse   993 TDIPERRDSGVGASLTRCNRHRLRWHSFQSSHRPSLNSVSLQINCQSVAQMNLLQKYSLLKLTAL 1057

  Fly   333 FDR----NKVSLDKRKP-FKRRRK----EEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIG 388
            .::    ||.......| |.:|.|    ::.::|||.:...::|..|.       :|..:::.:.
Mouse  1058 LEKYTPSNKHGFSWAVPKFMKRIKVPDYKDRSVFGVPLTVNVQRSGQP-------LPQSIQQAMR 1115

  Fly   389 ELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQ 453
            .|......:.||.|..|.|.:.:.|....||.    .||::  :...:.::::.:||::.|:||:
Mouse  1116 YLRNHCLDQVGLFRKSGVKSRIQALRQMNESA----EDNVN--YEGQSAYDVADMLKQYFRDLPE 1174

  Fly   454 PLLTNELIQLFYQCHT-LPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHN 517
            ||:||:|.:.|.|.:. :|...::.|:.....|||.|||..|::||.|.:.:......|:|...|
Mouse  1175 PLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTLLYFLSDVTAAVKENQMTPTN 1239

  Fly   518 VATIMAPSMF----------PPRYIHPS-----------DNNSIAEQ--VRMAAQCCRLTNILIL 559
            :|..:|||:|          .||.:...           :.|..|.|  ..|.|:|
Mouse  1240 LAVCLAPSLFHLNTLKRENSSPRVMQRKQSLGKPDQKDLNENLAATQGLAHMIAEC--------- 1295

  Fly   560 RGEKLFQVPNNLIVESQKTMMGKKGWHRHRNS-NEITAKP 598
              :||||||..:              .|.||| .|...||
Mouse  1296 --KKLFQVPEEM--------------SRCRNSYTEQELKP 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	63/243 (26%)
Dlc1	NP_001181869.1	SAM_DLC1	468..527	CDD:188990	13/62 (21%)
		RhoGAP_DLC1	1087..1305	CDD:239840	63/241 (26%)
		SRPBCC	1330..1533	CDD:387369
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810