DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and OPHN1

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_002538.1	Gene:	OPHN1 / 4983	HGNCID:	8148	Length:	802	Species:	Homo sapiens

Alignment Length:	667	Identity:	125/667 - (18%)
Similarity:	227/667 - (34%)	Gaps:	222/667 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 DDQDFSEFLNEYYLQSNSQSIEPEASY-EDGEMEAEWLVSA--GYPELTKPFEQGLEVSKKDLEP 72
            |..||.|.|..|     .|.:|....: :|...:...|:||  .|....:.|.|.|:..:.|.
Human    14 DSPDFRERLKCY-----EQELERTNKFIKDVIKDGNALISAMRNYSSAVQKFSQTLQSFQFDF-- 71

  Fly    73 ILTTLSKPH---AEAIVQLVRTLNKTVRVR-------------------------TKSRPKR-KP 108
            |..||:...   ||:..:....||:....|                         ||.|.|: :.
Human    72 IGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFRKEQIGFTKERKKKFEK 136

  Fly   109 DIRDVFREFDEQGTVTRSRSATPDSLDSLQIDEAWTN---NSLPTFVNVYEKNTETAIQCVEQ-- 168
            |....:...|....::..:..:......||:|:...|   :||.....:.|.........||.
Human   137 DGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVL 201

  Fly   169 --------SNEIYL---------KQNL----------------------RRTPSAPPKSGTYADI 194
                    ||.:.:         ||.|                      :|...||.
Human   202 AFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQ-------- 258

  Fly   195 FRGSQVRCDIP--------LYSAD----GVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESRSE 247
                  .|.:|        ||:.:    |:..:.|                 :|
Human   259 ------TCKLPGQPTIEGYLYTQEKWALGISWVKY-----------------YC----------- 289

  Fly   248 NDARSQKKKSSEVLSASENECGRLLPM---------PYNVLSFESICRDSSSLDS--CEVLDTCD 301
                 |.:|.::.|:        :.||         |.::.....:.|.:.|:|.  |..::|.:
Human   290 -----QYEKETKTLT--------MTPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNE 341

  Fly   302 IPSTLFTDVVLISETDMKRLQTILWLELATIFDRNKVSLDKRK-----PFKRRRKEEGNLFGVSI 361
            .|.|:  .:..:||.:.:     ||:|          ::|.::     |..::::.|.|..|..
Human   342 RPGTI--TLQALSEANRR-----LWME----------AMDGKEPIYHSPITKQQEMELNEVGFK- 388

  Fly   362 NALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLR-IGGHKQKTELLYNELESTFY--Q 423
                                |:.|.|..:..:|.:.|||.| :|.:.|..:||     :.|:  :
Human   389 --------------------FVRKCINIIETKGIKTEGLYRTVGSNIQVQKLL-----NAFFDPK 428

  Fly   424 NPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSID-QMNALSILCHLLP 487
            .|.::|.......:..::|.||.:||.|.:|::|..|.:.........::| ::.|:..|.:.||
Human   429 CPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLP 493

  Fly   488 PENRNTLRSLL-SFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCC 551
            .:||..|..|: ...|:..:.|: |.|...|:..|..|::.      .:..:::|..:.:..|..
Human   494 EKNREMLELLIRHLVNVCEHSKE-NLMTPSNMGVIFGPTLM------RAQEDTVAAMMNIKFQNI 551

  Fly   552 RLTNILILRGEKLFQVP 568
             :..|||....|::..|
Human   552 -VVEILIEHFGKIYLGP 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	48/218 (22%)
OPHN1	NP_002538.1	BAR_OPHN1	19..225	CDD:153317	39/212 (18%)
		PH	266..363	CDD:278594	23/154 (15%)
		BAR-PH_GRAF_family	267..370	CDD:269953	24/160 (15%)
		RhoGAP_Graf	363..559	CDD:239839	50/229 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	569..588
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..666
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..770
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	783..802
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910