Protein Alignment conu and ARHGAP40

DIOPT Version :9

• Sequence 1: NP_001036454.1
• Gene: conu / 3355133
• FlyBaseID: FBgn0039994
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001157903.1
• Gene: ARHGAP40 / 343578
• HGNCID: 16226
• Length: 674
• Species: Homo sapiens
• Alignment Length: 658
• Identity: 152/658 - (23%)
• Similarity: 244/658 - (37%)
• Gaps: 220/658 - (33%)

  Fly    34 EASYEDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRV 98
            |....:||.|::||...|...|....  ||:   .|.:.:|:||::....|:.:.:....::||
Human   107 EGQLPEGEAESQWLQDTGLSGLLGGL--GLD---GDHQELLSTLTQTQVAAVCRRLDIYARSVR- 165

  Fly    99 RTKSRPKRKPDIRDVFREFD------------------EQGTVTRSRSATPDSL-DSLQIDEAWT 144
            |....|.|  |:||||..|:                  ..|......:|.|..| :....:||:.
Human   166 RQHKTPVR--DVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGLQEQAGREEAFN 228

  Fly   145 NNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADIFRGSQVRCDIPLYSA 209
            .:|      .|.:.....:|                 .|.|.:.||.|      ..:|.:|.::.
Human   229 MDS------AYSEQAAVLLQ-----------------RSRPSRGGTSA------WGKCSLPKFTV 264

  Fly   210 DGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKESRSENDARSQKKKSSEVLSASENECGRLLPM 274
            .... ||.:|||.:.....|.|
Human   265 PKGR-LGVTRIGDLSLQDMRKV------------------------------------------- 285

  Fly   275 PYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELATIFDRNKVS 339
                          .||...|:...|||..           .|:||.:...|
Human   286 --------------PSLALIELTALCDILG-----------LDLKRSKAGKW------------- 312

  Fly   340 LDKRKPFKRRRKEEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIG 404
                      :..|..||||.:::|:..|.:|  ..|:.|||.|:.|:..|.:||...||:||:.
Human   313 ----------KAAETRLFGVPLDSLLEADHKV--LPSTQVPLVLQALLSCLEKRGLDMEGILRVP 365

  Fly   405 GHKQKTELLYNELESTFYQNPDNLDNLFRTATVH--ELSSLLKRWLRELPQPLLTNELIQLFYQC 467
            |.:.:.:.|..:||..||.      .||....||  :.|.||||::|:||.||||.|.:..|...
Human   366 GSQARVKGLEQKLERDFYA------GLFSWDEVHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVV 424

  Fly   468 HTLPSIDQ-MNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMF---- 527
            ..:|::.| :..|.:|..:||..|||.|::||.|...::..:..|||.:.||:|:|||::|
Human   425 PNIPNLKQRLQVLHLLILILPEPNRNALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLFLHQG 489

  Fly   528 -PPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVESQKTM-----------M 580
             ||:.  |.     .::.::|.....:..|::...:.|:.|.:.|:.:.:|..           .
Human   490 RPPKL--PK-----GKEKQLAEGAAEVVQIMVHYQDLLWTVASFLVAQVRKLNDSSSRRPQLCDA 547

  Fly   581 GKKGWHRHRNSN--------EITAK-------------------PSGKASNVGVGHDSTVINKYS 618
            |.|.|.|..:::        |.|.|                   ||.|     |.|   |:.:::
Human   548 GLKTWLRRMHADRDKAGDGLEATPKVAKIQVVWPIKDPLKVPLTPSTK-----VAH---VLRQFT 604

  Fly   619 TNLKHLHP 626
               :||.|
Human   605 ---EHLSP 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	75/227 (33%)
ARHGAP40	NP_001157903.1	RhoGAP	319..532	CDD:295372	75/227 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148558
Domainoid	1	1.000	114	1.000	Domainoid score	I6069
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	185	1.000	Inparanoid score	I3952
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D309300at33208
OrthoFinder	1	1.000	-	-		FOG0002326
OrthoInspector	1	1.000	-	-		otm42220
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860