DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and Ocrl

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001101726.2	Gene:	Ocrl / 317576	RGDID:	1594526	Length:	899	Species:	Rattus norvegicus

Alignment Length:	719	Identity:	136/719 - (18%)
Similarity:	228/719 - (31%)	Gaps:	268/719 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QDFSEFLNEYYL--QSNSQSIEP-----------------------EA-SYEDGEMEAEWLVSAG 51
            |.|..|:..:.:  ||...|:||                       || .|.:...|.||.::.
  Rat   236 QSFRFFVGTWNVNGQSPDSSLEPWLNCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWAMAV- 299

  Fly    52 YPELTKPFEQGLEVSKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFRE 116
                    |:||....|..:              |||||.:...:.|..|.  .:...|||:..|
  Rat   300 --------ERGLPSKAKYKK--------------VQLVRLVGMMLLVFAKK--DQCQYIRDIATE 340

  Fly   117 FDEQGTVTRSRSATPDSLDSLQIDEAWT----NNSLPTFVNVYEKN----------------TET 161
              ..||....:......:....:....|    |:.|...|..:|:.                .:|
  Rat   341 --TVGTGIMGKMGNKGGVAMRFVFHNTTFCIVNSHLAAHVEEFERRNQDYKDICARMSFSVPNQT 403

  Fly   162 AIQ-------------------CVEQSNEI--------------YLKQNLRRTPSAPPKSGTYAD 193
            ..|                   |:..:||:              :.:.|::||     :...:.|
  Rat   404 LPQVNIMKHDVVIWLGDLNYRLCMPDANEVKSLINKNELQKLLKFDQLNIQRT-----QKKAFVD 463

  Fly   194 IFRG------------------SQVRCDIP------LYSADGVELLGYSRIGTIQFPRNRSVSDP 234
            ...|                  |..:|.:|      |:....|..|.|.....::...::.||..
  Rat   464 FNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWRGINVNQLHYRSHMELKTSDHKPVSAL 528

  Fly   235 FCSIGRSKESRSENDARSQKKKSSE---VLSASENECGRLLPMPYNVLSFESI------------ 284
            | .||....     |.|..:|...:   ::...||:....|.:......||::
  Rat   529 F-HIGVKVV-----DERRYRKVFEDIVRIMDRMENDFLPSLDLSRREFMFENVKFRQLQKEKFQI 587

  Fly   285 -------CRDS-----SSLDSC-------------EVLDTCDIPSTLFT--DVVLISETDMKRLQ 322
                   |..|     :....|             |..:|.||...::.  |.|.|..:...:::
  Rat   588 SNNGQVPCHFSFIPKLNDTQYCKPWLRAEPFEGYLEPNETIDISLDVYVSKDSVTILNSGEDKIE 652

  Fly   323 TILWLELATIFDRNK-----VSLDKRKPFKRRRKEEGN----LFGVSINALIR-----RDQQVTG 373
            .||.|.|    ||.|     :|              ||    .||.|:.||.|     |:..||
  Rat   653 DILVLHL----DRGKDYFLTIS--------------GNYLPSCFGTSLEALCRMKRPIREVPVT- 698

  Fly   374 TDSSLVPL----FLEK---------------------------LIGELLRRGSREEGLLRIGGHK 407
               .|:.|    ||||                           |:..|.:....:|.|.:..|.:
  Rat   699 ---KLIDLEEDSFLEKEKSLLQMVPLDEGTSERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQ 760

  Fly   408 QKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPS 472
            ::.:.:.:.|:::.   |:.:     ..:.|.::..|..:|..||:|::..||.|   :|  |.|
  Rat   761 EELQQIIDCLDTSI---PETI-----PGSNHSVAEALLIFLEALPEPVICYELYQ---RC--LDS 812

  Fly   473 IDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMF--PPRYI--- 532
            .........:...||..:||..|.|::|...::...|.|.::.:.:||:....:.  ||..:
  Rat   813 AHDPRICKQVISQLPRCHRNVFRYLMAFLRELLKFSDYNNVSTNMIATLFTSLLLRPPPNLMARQ 877

  Fly   533 HPSD 536
            .|||
  Rat   878 TPSD 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	50/222 (23%)
Ocrl	NP_001101726.2	PH_OCRL1	11..115	CDD:270182
		Clathrin box 1	73..77
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..186
		5-phosphatase. /evidence=ECO:0000250	235..561		63/362 (17%)
		INPP5c_INPP5B	238..531	CDD:197327	55/325 (17%)
		ASH. /evidence=ECO:0000250	562..676		23/131 (18%)
		RhoGAP_OCRL1	666..894	CDD:239845	53/247 (21%)
		Clathrin box 2	700..704		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910