DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and Stard8

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_038955618.1	Gene:	Stard8 / 312113	RGDID:	1560770	Length:	1136	Species:	Rattus norvegicus

Alignment Length:	603	Identity:	127/603 - (21%)
Similarity:	238/603 - (39%)	Gaps:	164/603 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SQSIEPEASYEDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTTLSKPHAEAIVQLVRTL 92
            ::.|:.||..||.|.|.                                 |..|.:.|::.|..|
  Rat   405 AEPIQAEAEDEDEEGEG---------------------------------SYAHLDDILEHVWGL 436

  Fly    93 NKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTRSRSATPDSLDSLQIDEAWTNNSLPTFVNVYEK 157
            .:.|.:.:::   ..||:|...:|.:|:                 :.:||             ..
  Rat   437 QQRVELWSQA---MYPDLRPGDKEEEEE-----------------EEEEA-------------TS 468

  Fly   158 NTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADIFRG--SQVRCDIPLYSADG----VE-LL 215
            :.|.|...||..:|...:..              :.:.||  ::|:.::||...|.    || |:
  Rat   469 SVEIATAEVEGQDEALAQAE--------------SQVHRGFPTEVKEEVPLIVLDQAPTVVEPLV 519

  Fly   216 GYSRIGTIQFPRN--RSVSDPFC----------SIGRSKESRSENDARSQKKKSSEVLSA----- 263
            ........|.|..  .|.::|..          ||..:..|.||.|:.......::|..|
  Rat   520 QAEAPAQAQHPEQDANSAAEPISASSLSVEEGHSISDTAVSSSELDSSGNSVNEADVADALAGPN 584

  Fly   264 -------SENECGRLLPMPYNVL---SFESICRDSSSLDSCEVLDTCDIPSTLFT-DVVLISETD 317
                   .::..|..|..|...|   ||::..|.|.:.:|.|:       :..|. .:.|:.:..
  Rat   585 ASVPRERRDSGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEI-------NRQFAGQINLLHKGS 642

  Fly   318 MKRLQTILWLELATIFDRNKVSLDKRKPFKRRRKEE---GNLFGVSINALIRRDQQVTGTDSSLV 379
            :.||..  ::|..|:..:........|..||.:..:   .::|||.....::|..|.       :
  Rat   643 LLRLTG--FMEKYTVPHKQAWVWSMPKFMKRNKTPDYRGHHVFGVPPLIHVQRTGQP-------L 698

  Fly   380 PLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLL 444
            |..:::.:..|..:...:.|:.|..|.|.:.:.| .::..|   :|||:  .:...:.::::.||
  Rat   699 PQSIQQAMRYLRSQCLDQVGIFRKSGVKSRIQSL-RQMNET---SPDNV--CYEGQSAYDVADLL 757

  Fly   445 KRWLRELPQPLLTNELIQLFYQCH-TLPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLK 508
            |::.|:||:|:.|::|...|.|.: .||....:.|......|||.|||..|::||.|.:.|.:.:
  Rat   758 KQYFRDLPEPIFTSKLTTTFLQIYQLLPKEQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAE 822

  Fly   509 DINKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQVR-----------------MAAQCCRLTNI 556
            : |:|...|:|..:|||:|   :::.|..:|.:.:::                 |||  .:..:.
  Rat   823 E-NQMTAGNLAVCLAPSIF---HLNVSKKDSPSPRIKSKRSLVGRPGPRDLSENMAA--TQGLSH 881

  Fly   557 LILRGEKLFQVPNNLIVE 574
            :|...:||||||.:::|:
  Rat   882 MISDCKKLFQVPQDMVVQ 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	62/237 (26%)
Stard8	XP_038955618.1	SAM_DLC1,2-like	73..132	CDD:188937
		RhoGAP	682..896	CDD:413382	61/232 (26%)
		SRPBCC	923..1127	CDD:417480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810