DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and Bcr

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_038955099.1	Gene:	Bcr / 309696	RGDID:	1307993	Length:	1270	Species:	Rattus norvegicus

Alignment Length:	790	Identity:	152/790 - (19%)
Similarity:	243/790 - (30%)	Gaps:	347/790 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 SAGYPELTK----PFEQGLEVSKKDLEPIL----TTLSKPHAEAIVQLVRTLNKTVRVRTKSRPK 105
            ::|..|.||    ..|:|||:.|..|..||    |.||  |.||::..::.|....   |.|:|.
  Rat   477 ASGALEPTKASELDLEKGLEMRKWVLSGILASEETYLS--HLEALLLPMKPLKAAA---TTSQPV 536

  Fly   106 -----------RKPDIRDVFREFDEQGTVTRSRSATPDSLDSLQIDEAWTNNS------------ 147
                       :.|::.::.:||.: |...|.              :.|::..
  Rat   537 LTSQQIETIFFKVPELYEIHKEFYD-GLFPRV--------------QQWSHQQRVGDLFQKLASQ 586

  Fly   148 ---LPTFVNVYEKNTETAIQCVE--------------QSNE------------------------ 171
               ...||:.|....|||.:|.:              :||:
  Rat   587 LGVYRAFVDNYGVAMETAEKCCQANAQFAEISENLRARSNKDVKDSTTKNSLETLLYKPVDRVTR 651

  Fly   172 --IYLKQNLRRTPSAPP--------------------------------KSGTYADIFRGS---- 198
              :.|...|:.|||:.|                                |.|.:..:.:.|
  Rat   652 STLVLHDLLKHTPSSHPDHSLLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVE 716

  Fly   199 --------------------------------QVRC-------DIPLYSADGVELLGYSRIGTIQ 224
                                            |..|       |:.....|.:|.|
  Rat   717 LVEGARKLRHIFLFTDLLLCTKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAL--------- 772

  Fly   225 FPRNRSVSDPFCSIGRSKESRSENDARSQKK--KSSEVL-----SASENECGRLLPMP------- 275
             |....|.|......:.|.|:.::|.:.:|:  |.|:|:     ..||.|...||..|
  Rat   773 -PNIPLVPDEELDALKIKISQIKSDIQREKRANKGSKVMERLRKKLSEQESLLLLMSPSMAFRVH 836

  Fly   276 ------YNVLSF---------ESI------CRDSSSL---------DSCEVLDTC-DIPSTL--- 306
                  |..|..         |||      |..|.||         :||..|.|. .||.|:
  Rat   837 SRNGKSYTFLISSDYERAEWRESIREQQKKCFKSFSLTSVELQMLTNSCVKLQTVHHIPLTINKE 901

  Fly   307 ---------FTDVVLISETDMKRLQTIL---------------------------W-----LEL- 329
                     |...::.|.|..|:...:.                           |     :||
  Rat   902 DDESPGLYGFLHAIVHSATGFKQSSNLYCTLEVDSFGYFVNKAKTRVYRDTTEPNWNEEFEIELE 966

  Fly   330 -------------------------------------------------ATIFDRNKVSLDKRKP 345
                                                             .|:.|.|.:.:.....
  Rat   967 GSQTLRILCYEKCYNKMKMAKEDGESADKLMGKGQVQLDPQTLQDRDWQRTVIDMNGIEVKLSVK 1031

  Fly   346 FKRR---------RKEEGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLL 401
            |..|         ||:.| :|||.|..:.:|::       |.||..:.:.:.|:.|||..|.|:.
  Rat  1032 FTSREFSLKRMPSRKQTG-VFGVKIAVVTKRER-------SKVPYIVRQCVEEIERRGMEEVGIY 1088

  Fly   402 RIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQ 466
            |:.|  ..|::  ..|::.|..|..::..:.....|:.::..||.:.||||:||.|:|....|.:
  Rat  1089 RVSG--VATDI--QALKAAFDVNNKDVSVMMSEMDVNAIAGTLKLYFRELPEPLFTDEFYPNFAE 1149

  Fly   467 CHTL--PSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPP 529
            ...|  |...:...|::|.. ||..|..|...||.....:...:.:|||::||:||:..|::
  Rat  1150 GIALSDPVAKESCMLNLLLS-LPEANLLTFLFLLDHLKRVAEKETVNKMSLHNLATVFGPTL--- 1210

  Fly   530 RYIHPSDNNS 539
              :.||:..|
  Rat  1211 --LRPSEKES 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	53/186 (28%)
Bcr	XP_038955099.1	Bcr-Abl_Oligo	3..75	CDD:401106
		RhoGEF	501..688	CDD:395496	34/206 (17%)
		PH-like	683..876	CDD:418428	34/202 (17%)
		C2_ABR	912..1032	CDD:176068	9/119 (8%)
		RhoGAP_Bcr	1051..1251	CDD:239852	53/185 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910