DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and Arhgap12

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001100827.2	Gene:	Arhgap12 / 307016	RGDID:	1310017	Length:	838	Species:	Rattus norvegicus

Alignment Length:	727	Identity:	141/727 - (19%)
Similarity:	257/727 - (35%)	Gaps:	225/727 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNSNTDLHH------SDDQD-----------FSEFLNEYYLQ------SNSQSIE-----PEASY 37
            :|.:.||.|      ||...           |..|....:|.      |..||.:     .|.::
  Rat   144 LNLSLDLTHNNGKFNSDSHSPKVSSQNRTRLFGHFPGPEFLDIEKTSFSQEQSCDSAGEGSERTH 208

  Fly    38 EDGEMEAEWLVSAGYPEL--TKPFEQG------------LEVSKKDLEPILTTLSKPHAEAIVQL 88
            :|.|...| |.|:...::  |.|..||            |::|:..|.|:      |.:.|| |:
  Rat   209 QDSESGDE-LSSSSTEQMRATTPPNQGRPDSPVYANLQELKISQSALPPL------PGSPAI-QV 265

  Fly    89 -------------VRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQG----------------TVT 124
                         ....|:|.:.||...|:...|: ...|:|...|                :.:
  Rat   266 NGEWETHKDSSGRCYYYNRTTQERTWKPPRWARDV-STSRDFQSPGEQEPLSSEENYHSSCFSQS 329

  Fly   125 RSRSATPDSLDSLQID-------------EAWTNN-------------------SLPTFVNVYEK 157
            .|:..:|....|.::|             |.|..:                   .||.    |..
  Rat   330 DSQCGSPPRGWSEELDERGHTLYTSDYTKEKWLKHVDDQGRQYYYSADGSRSEWELPK----YNA 390

  Fly   158 NTETAIQCVE-----------------QSNEIYLKQNLRRTPS----------APPKSGTYAD-- 193
            :::...:.::                 :.:.|.|..|.:.:|:          :||.|..:.|
  Rat   391 SSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDSNDKDSPTSTKLCLPENESPPTSTKHQDPG 455

  Fly   194 ------------IFRGSQVRCDIPLYSADGVELLGYSRI-------GTIQFPRNRSVSDPFCSIG 239
                        ...|.:||.:   :.:....|.|.|.:       .|..|..|:|..:....:.
  Rat   456 QEKYGLLNVTKITENGKKVRKN---WLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLK 517

  Fly   240 RSKESRSENDARSQK-------KKSSEVLSASENECGRLLPMPYNVLSFESICRDSSSLDSCEVL 297
            .:....:..|..|:|       ::.:|:|..|:|:.  ::...:.||| .:|....:..|.....
  Rat   518 GAAIEMASKDKSSKKNVFELKTRQGTELLIQSDNDA--VINDWFKVLS-STINNQVAEADEAAEE 579

  Fly   298 DTCDIPSTLFTDVVLISETDMKRLQTILWLELATIFD----RNKVSLDK---RKPFKRRRKEEG- 354
            :..|.|.....|    .|.|.|.|:.:..::.:::..    :.|.:|.|   |:|..:..:|:|
  Rat   580 EAPDSPGVEKQD----KEKDQKELKKLRSMKGSSMDSSEQKKTKKNLKKFLTRRPTLQAVREKGY 640

  Fly   355 ---NLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHK---QKTELL 413
               .:||.::..|.:|:   .||    ||.|::..|..:...|...:|:.|:.|:.   ||....
  Rat   641 IKDQVFGSNLANLCQRE---NGT----VPKFVKLCIEHVEEHGLDVDGIYRVSGNLAVIQKLRFA 698

  Fly   414 YNELESTFYQNPDNLD-NLFRTATVHELSSLLKRWLRELPQPLLT----NELIQLFYQCHTLPSI 473
            .|        :.:.|| |..:...:|.::..||.:.||||:||.|    |:.:....|    ...
  Rat   699 VN--------HDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQ----EPR 751

  Fly   474 DQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPR------YI 532
            .::.|:..|...||..|::|::.|......:|...:.|:|...::|.:..|::..|.      .:
  Rat   752 QRVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVFGPTLLKPERETGNIAV 816

  Fly   533 HPSDNNSIAEQV 544
            |....|.|.|.:
  Rat   817 HTVYQNQIVELI 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	49/203 (24%)
Arhgap12	NP_001100827.2	SH3_ARHGAP12	13..72	CDD:213003
		SH3-WW_linker	69..264	CDD:406914	29/127 (23%)
		WW	266..296	CDD:238122	5/29 (17%)
		PH_ARHGAP9-like	457..568	CDD:270053	21/116 (18%)
		RhoGAP_ARHGAP27_15_12_9	646..831	CDD:239868	49/202 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910