Protein Alignment conu and Arhgap18

DIOPT Version :9

• Sequence 1: NP_001036454.1
• Gene: conu / 3355133
• FlyBaseID: FBgn0039994
• Length: 629
• Species: Drosophila melanogaster
• Sequence 2: NP_001164046.1
• Gene: Arhgap18 / 293947
• RGDID: 1305053
• Length: 665
• Species: Rattus norvegicus
• Alignment Length: 682
• Identity: 173/682 - (25%)
• Similarity: 280/682 - (41%)
• Gaps: 199/682 - (29%)

  Fly    25 QSNSQSI---EPEASYEDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTTLSKPHAEAIV 86
            |...::|   ||    ::||:|.|||..||   |:..|.:..:.|::.: ..|:||::..|.|:.
  Rat    92 QEGQEAIVVKEP----DEGELEEEWLKEAG---LSNLFGESADDSQESI-VFLSTLTRTQAAAVQ 148

  Fly    87 QLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTRSRSATPDSLDSLQIDEAWTNNSLPTF 151
            :.|.|:::|  :|.||:....||:||:|         .:.|.|...|.|...:....||
  Rat   149 KRVETVSQT--LRKKSKQYHIPDVRDIF---------AQQREAQEKSPDDSDLRSVRTN------ 196

  Fly   152 VNVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADIFRGSQVRCDIPLYSADGVELLG 216
                 :|.:........|..:..|:.:.|.|...|.|.|            ||.|
  Rat   197 -----ENEDQGKDDQPSSGAVDNKEPIPRVPEDIPASET------------DINL---------- 234

  Fly   217 YSRIGTIQFPRNRSVSDPFCSIGRSKESRSENDA-----RSQKKKSSEVLSASENECGRLLPMPY 276
                 .:.| ..::|:....|..|.:::|. |||     |..|.|:      .....|.|.|.
  Rat   235 -----EVSF-AEQAVNQKELSKERMQKTRG-NDASLPSFRLPKDKT------GTTRIGDLAPQ-- 284

  Fly   277 NVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELATIFDRNKVSLD 341
                                                    |||::..:..:||..::|...|.|.
  Rat   285 ----------------------------------------DMKKVCYLSLIELTALYDVLGVELK 309

  Fly   342 KRKPFKRRRKEEGNLFGVSINALIRRDQ-QVTGTDSSLVPLFLEKLIGELLRRGSRE-EGLLRIG 404
            ::|..|.:.::.| |||:.:..|:.:|| :|.||   .:||..:||| ..:..||.| ||||||.
  Rat   310 QQKAVKIKTRDSG-LFGIPLTILLEQDQRKVPGT---RIPLIFQKLI-SCIEEGSLETEGLLRIP 369

  Fly   405 GHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHT 469
            |...:.:.|..|||:.||:...|.:::.:    |:.:||||.:|||||||||:.|.::.|.....
  Rat   370 GAAMRVKNLCQELEAKFYEGTFNWESVKQ----HDAASLLKLFLRELPQPLLSTEYLKAFQAVQN 430

  Fly   470 LPS-IDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIH 533
            ||: .:|:.||::|..|||..||:||::||.|...:|:.|:.|||...|||.:|||::|   ..|
  Rat   431 LPTKKEQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTAVNVAMVMAPNLF---MCH 492

  Fly   534 PSD-NNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVE--------------SQKTMMGKK 583
            ... .:|...:..|||......::||...:.|:.:|..::.:              :.|.::.|.
  Rat   493 ALGLKSSEHREFEMAAGTANTMHLLIRYQKLLWTIPKFIVNQVRKHNTAHQKKERRAMKKLLKKM 557

  Fly   584 GWHRHRNSNEITAK-----PSG----------------------KASNV---------------- 605
            .:.|.::..:..|.     |.|                      |||:|
  Rat   558 AYDREKHEKQDRAANGADVPQGVIRVQAPHLSKVSMAIQLTEELKASDVLARFLSQESGVAQTLK 622

  Fly   606 -----------GVGHDSTVINKYSTNLKHLHP 626
                       .:|......:.|..:|.||:|
  Rat   623 KGEVFLYEIGGNIGERCLDDDTYMKDLYHLNP 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	84/237 (35%)
Arhgap18	NP_001164046.1	RhoGAP_ARHGAP18	323..536	CDD:239856	84/223 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342453
Domainoid	1	1.000	109	1.000	Domainoid score	I6215
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3829
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D309300at33208
OrthoFinder	1	1.000	-	-		FOG0002326
OrthoInspector	1	1.000	-	-		otm46373
orthoMCL	1	0.900	-	-		OOG6_108161
Panther	1	1.100	-	-	O	PTHR14963
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760