DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and Myo9a

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_006511271.1	Gene:	Myo9a / 270163	MGIID:	107735	Length:	2633	Species:	Mus musculus

Alignment Length:	655	Identity:	136/655 - (20%)
Similarity:	223/655 - (34%)	Gaps:	194/655 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DLHHSDDQDFSEFLNEYYLQSNSQ----SIEPEASYEDGEMEAEWLVSAG-YPELTKPFEQGLEV 65
            |....|..|..|.|......|:|:    |...:||:.|.||.::...|.. ..:|.|...|| |:
Mouse  1750 DTEEDDYDDIIEPLLSLDQASHSELGPVSSLGQASHSDSEMTSQRFSSVDEQAKLHKAMSQG-EI 1813

  Fly    66 SKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTRSRSAT 130
            :|..:....:.|......|.::......:..:..|:.:|..:.:|...|...|    ||   .|.
Mouse  1814 TKLAVRQKASDLDIRPQRAKMRFWAKGKQGEKKTTRVKPASQSEISSFFPGPD----VT---PAH 1871

  Fly   131 PDSLDSLQIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPKSGTYADIF 195
            |.|      ||....:..|..      :.|....|.::     .|:|...:|.|..|.|.
Mouse  1872 PFS------DELTQYHPTPPL------SPELPGSCRKE-----FKENKEPSPKAKRKRGV----- 1914

  Fly   196 RGSQVRCDIPLYSADGVELLGYSRIGTIQFPRNRSVSDPFCSIGRSKES---RSENDARSQKKKS 257
            :.|.|..|...:..|.|:::.             |.||.     :|.:.   :..||..::..|.
Mouse  1915 KISSVALDSMHWQNDSVQIIA-------------SASDL-----KSMDEFLLKKMNDLDNEDSKK 1961

  Fly   258 SEVLSASENECGRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQ 322
            ..::.....:.  |.....|:.         ||..|...:|  |..|..:.|:..:.|..:::..
Mouse  1962 DTLVDVVFKKA--LKEFRQNIF---------SSYSSALAMD--DGKSIRYKDLYALFEQILEKTM 2013

  Fly   323 TI-----------LWLELATIF-DR--NKV-SLDKRKP------FKRRRKEEGNL---------- 356
            .:           :|:....:| |.  |:. :||...|      .|:|||:|.:|
Mouse  2014 RLEQRDWNESPVRVWVNTFKVFLDEYMNEFKTLDSTAPKVLKTERKKRRKKETDLVEEHNGHIFK 2078

  Fly   357 ---------------------------------------------------------FGVSINAL 364
                                                                     |||.::.|
Mouse  2079 ATQYSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVELSRL 2143

  Fly   365 IRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLD 429
            ...|:        .|||.:||||..:...|...||:.|..|...|.:.|...|::.  ....|||
Mouse  2144 TSEDR--------AVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTD--AESVNLD 2198

  Fly   430 NLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPS-----------IDQMNALSILC 483
            :.    .:|.::|:.|:|||:||.||:|.||.:.|.:...|..           |||::.    .
Mouse  2199 DY----NIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSR----T 2255

  Fly   484 HLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAA 548
            ||      |||..|:.....|...:|.|:|:.:.:|.:.||.:.  |....:|.....:.:....
Mouse  2256 HL------NTLERLIFHLVRIALQEDTNRMSANALAIVFAPCIL--RCPDTTDPLQSVQDISKTT 2312

  Fly   549 QCCRL 553
            .|..|
Mouse  2313 TCVEL 2317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	59/276 (21%)
Myo9a	XP_006511271.1	RA_Myosin-IXa	15..110	CDD:340736
		MYSc_Myo9	160..1006	CDD:276836
		DUF5401	<968..>1283	CDD:375164
		IQ	1117..1138	CDD:197470
		PEHE	<1827..1891	CDD:373705	15/82 (18%)
		C1	2075..2123	CDD:237996	0/47 (0%)
		RhoGAP_myosin_IX	2136..2321	CDD:239842	58/208 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910