DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and Racgap1

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001240737.1	Gene:	Racgap1 / 26934	MGIID:	1349423	Length:	628	Species:	Mus musculus

Alignment Length:	647	Identity:	133/647 - (20%)
Similarity:	239/647 - (36%)	Gaps:	162/647 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QDFSEFLNEYYLQSNSQSIEPEASYEDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTTL 77
            :||.:|..:|  |..:|.:|   .::|..::||...||        .:..|:.::..::..:...
Mouse    36 KDFEDFRKKY--QRTNQELE---KFKDLLLKAETGRSA--------LDVKLKHARNQVDVEIKRR 87

  Fly    78 SKPHAEAI-----VQLVRTL-----NKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTRSRSATPD 132
            .:..||..     :||:|.:     :.::::    ..::|..:..:.|.....|....:|.:|.|
Mouse    88 QRAEAECAKLEQQIQLIRDILMCDTSGSIQL----SEEQKSALAFLNRGQASSGHAGNNRLSTID 148

  Fly   133 SLDSL-------QIDEA--WTNNSLPTF-VNVYEKNTETAIQCVEQSNEIYLKQNLRRTPSAPPK 187
            ...|:       :.||:  |.::.:..| :...||....:.|.::             .|..|.|
Mouse   149 ESGSILSDISFDKTDESLDWDSSLVKNFKMKKREKRRSNSRQFID-------------GPPGPVK 200

  Fly   188 S----GTYADIFRGSQVRCDIPLYSADGVELLGYSRIGTI-QFPRNRSVSDPFCSI-------GR 240
            .    |:..|....|.|........:||..:...|.|.|: .:.|:|..|.|...:       .|
Mouse   201 KTCSIGSTVDQANESIVAKTTVTVPSDGGPIEAVSTIETLPSWTRSRGKSGPLQPVNSDSALNSR 265

  Fly   241 SKESRSENDARSQKKKS---------SEVLSASEN--ECGRLLPMPYNVLSFESICRDSSSLDSC 294
            ..|.|::.|.....:.:         |:.:...|:  .||:.:  .:..||.:  |||...:...
Mouse   266 PLEPRTDTDNLGTPQNTGGMRLHDFVSKTVIKPESCVPCGKRI--KFGKLSLK--CRDCRLVSHP 326

  Fly   295 EVLDTCD---IPSTLFTDVVLISETDMKRLQTILWLELATIFDRNKVSLDKRKPFKRRRKEEGNL 356
            |..|.|.   ||..:.|.|                          |:.             ||.|
Mouse   327 ECRDRCPLPCIPPLVGTPV--------------------------KIG-------------EGML 352

  Fly   357 FGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTF 421
            ......|            |.::|..:...:.|:.:||..|.||.||.|    .:....||:..|
Mouse   353 ADFVSQA------------SPMIPAIVVSCVNEIEQRGLTEAGLYRISG----CDRTVKELKEKF 401

  Fly   422 YQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQMNALSILCHL- 485
            .: ...:..|.:...:|.:.||||.:||.|.:||||..|.:.|.:...:  .|:.|:.:.:...
Mouse   402 LK-VKTVPLLSKVDDIHVICSLLKDFLRNLKEPLLTFWLSKAFMEAAEI--TDEDNSTAAMYQAV 463

  Fly   486 --LPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAA 548
              ||..||:||..|:.....:....| .||::.|:|.:..|::......:|       :.|.|..
Mouse   464 SELPQANRDTLAFLMIHLQRVSQSPD-TKMDIANLAKVFGPTIVAHTVPNP-------DPVTMFQ 520

  Fly   549 QCCRLTNILILRGEKLFQVP----NNLIVESQKTMMGKKGWHRHRNSNEITAKPSGKASNVG 606
            ...|...::    |:|..:|    |..::..|:.:..::|     |.|.....|..|.|.:|
Mouse   521 DIKRQLKVV----ERLLSLPLEYWNQFMMVDQENIDSQRG-----NGNSTPRTPDVKVSLLG 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	54/226 (24%)
Racgap1	NP_001240737.1	Tropomyosin	43..>108	CDD:395200	15/77 (19%)
		Interaction with SLC26A8. /evidence=ECO:0000250	107..286		34/195 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..201		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..284		8/41 (20%)
		C1_MgcRacGAP	286..339	CDD:410371	13/56 (23%)
		RhoGAP_MgcRacGAP	347..540	CDD:239847	55/236 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910