DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and Srgap3

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_006506207.1	Gene:	Srgap3 / 259302	MGIID:	2152938	Length:	1104	Species:	Mus musculus

Alignment Length:	776	Identity:	137/776 - (17%)
Similarity:	252/776 - (32%)	Gaps:	276/776 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 KKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDE------------ 119
            |||.| |:........|...|||... |.:..:::||.:...|:::.||...|
Mouse     8 KKDKE-IIAEYEAQIKEIRTQLVEQF-KCLEQQSESRLQLLQDLQEFFRRKAEIELEYSRSLEKL 70

  Fly   120 ----QGTVTRSRS---------ATP-------------DSLDSLQIDEAWTNNSL-------PTF 151
                ...:..||.         .:|             :|.|...:::.:.||.:       ...
Mouse    71 AERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDV 135

  Fly   152 VNVYEKNTETAIQCVEQ----SNEIYLKQNLRRTPSAPPKSGTYADIFRGSQVRCDIPLYSADGV 212
            :.:::|:.|..:|..|:    :||:|....            || .::....:..:..|..|:..
Mouse   136 IRLFKKSKEIGLQMHEELLKVTNELYTVMK------------TY-HMYHAESISAESKLKEAEKQ 187

  Fly   213 ELLGYSRIGTIQF--------PRNRSVSDPFCSIGRSKESR----SENDARSQKKKSSEVLS-AS 264
            |...:::.|.:..        |:.||   ....|.:.||.|    |||..:..|.::..:|: |:
Mouse   188 EEKQFNKSGELSMNLLRHEDRPQRRS---SVKKIEKMKEKRQAKYSENKLKCTKARNDYLLNLAA 249

  Fly   265 EN---------------ECGRL-------------LPMPYNVLS-----FESICRDSSSLDSCE- 295
            .|               :|..|             |...||:.:     .:.|.....:|||..
Mouse   250 TNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSD 314

  Fly   296 ---VLDTC--------------------------------------DIPSTLFT------DVVLI 313
               |:|.|                                      .:.|.|.|      :|...
Mouse   315 KHTVMDMCSQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKT 379

  Fly   314 SETDMKRLQTILWLELATIFD-------------------RNKVSLDKRKPFKRRRKEEGNLF-- 357
            .:..|:.||.:|.:|...:.|                   .:|:::.||    |..::|..:|
Mouse   380 LDATMQTLQDMLTVEDFDVSDAFQHSRSTESIKSAASETYMSKINIAKR----RANQQETEMFYF 440

  Fly   358 -----GVSINALI---------------------------------------------------- 365
                 .|:.:.||
Mouse   441 TKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTSRRDGRLRLPHFPWLSCPPAPHFVPHP 505

  Fly   366 ----RRDQQVTGTDS-SLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNP 425
                ||:.:....|| ..:||.:|..|..:...|.:::|:.|:.|    :::..|:::::|.:..
Mouse   506 AFQGRRNARTRNQDSGQAIPLVVESCIRFINLYGLQQQGIFRVPG----SQVEVNDIKNSFERGE 566

  Fly   426 DNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPS-IDQMNALSILCHLLPPE 489
            |.|.:......::.::.:||.:.|.|..||...|..|.......|.: .|:::.:..:...||..
Mouse   567 DPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDLISTIKLENPADRVHPIQQILITLPRV 631

  Fly   490 NRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHPSDNNSIAEQVRMAAQCCRLT 554
            ....:|.|.:|.|.:....|.|.|:.:|:|....|::     :|..|..   :.|...|....:.
Mouse   632 VIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFGPTL-----MHIPDGQ---DPVSCQAHVNEVI 688

  Fly   555 NILILRGEKLFQVPNNLIVES---QKTMMGKKGWHRHRNSNEITAKPSGKASNVG-VGHDS 611
            ..:|:..|.:|..|..|  |.   :|.|.|         ..|....|..:...:. |.||:
Mouse   689 KTIIIHHEAIFPSPREL--EGPVYEKCMAG---------GEEYCDSPHSEPGTIDEVDHDN 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	52/287 (18%)
Srgap3	XP_006506207.1	F-BAR_srGAP3	26..278	CDD:153368	46/268 (17%)
		RhoGAP_srGAP	510..694	CDD:239848	43/195 (22%)
		SH3_srGAP1-3	753..805	CDD:212888
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910