DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and Stard13

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001156965.1	Gene:	Stard13 / 243362	MGIID:	2385331	Length:	1132	Species:	Mus musculus

Alignment Length:	421	Identity:	97/421 - (23%)
Similarity:	172/421 - (40%)	Gaps:	81/421 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 ELLGYSRI----GTIQFPRNRSVSDPF----CSIGRSKESRSENDARS-QKKKSSEVLSASENEC 268
            ||..:|.:    |...||....|:..|    .|.||:..|..|.|..| .:.:::.|....::..
Mouse   510 ELQSHSTLAGDPGLSPFPSPNQVTLDFEGNSVSEGRTTPSDVERDRTSLNESEATGVRERRDSGV 574

  Fly   269 GRLLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQTILWLELATIF 333
            |..|..|...|.:.|.           .|.....||.....:...:...:..||....|.|..|.
Mouse   575 GASLTRPNRRLRWSSF-----------QLSHQPQPSPATPHISSQTAAQLNLLQRFSLLRLTAIM 628

  Fly   334 DR----NK------------------VSLDKRK--PFKRRRK----EEGNLFGVSINALIRRDQQ 370
            ::    ||                  ||::.|.  .|.:|.|    .:..:|||.:...::|..|
Mouse   629 EKYSMSNKHGWTCLSAQSAPGALHDLVSVNSRSVPKFMKRIKAPDYRDKAVFGVPLIVHVQRTGQ 693

  Fly   371 VTGTDSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTA 435
            .       :|..:::.:..|......:.||.|..|.|.:...| .::...|   |||:.  :...
Mouse   694 P-------LPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHAL-RQMNENF---PDNVS--YEDQ 745

  Fly   436 TVHELSSLLKRWLRELPQPLLTNELIQLFYQCHT-LPSIDQMNALSILCHLLPPENRNTLRSLLS 499
            :.::::.::|::.|:||:||.||:|.:.|...:. :|...::.|:.....||..|||..|::||.
Mouse   746 SAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLADENREALQTLLC 810

  Fly   500 FFNIIINLKDINKMNVHNVATIMAPSMF---------PPRYIHPS------DNNSIAEQVRMAAQ 549
            |.:.::||.|.|:|...|:|..:|||:|         .|:.|...      |...:.|.:..|..
Mouse   811 FLHDVVNLVDENQMTPMNLAVCLAPSLFHLNLLKKESSPKVIQKKYATGKPDQKDLNENLAAAQG 875

  Fly   550 CCRLTNILILRGEKLFQVPNNLIVESQKTMM 580
            ...    :|....:||:||:.::.:|:.:.:
Mouse   876 LAH----MITECNRLFEVPHEMVAQSRDSYL 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	59/235 (25%)
Stard13	NP_001156965.1	SAM_DLC2	57..120	CDD:188991
		SAM	61..120	CDD:197735
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..256
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..343
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..443
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..578		15/63 (24%)
		RhoGAP_DLC1	676..893	CDD:239840	59/233 (25%)
		SRPBCC	920..1123	CDD:301327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810