DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and Arhgap22

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	XP_006519017.1	Gene:	Arhgap22 / 239027	MGIID:	2443418	Length:	738	Species:	Mus musculus

Alignment Length:	307	Identity:	78/307 - (25%)
Similarity:	135/307 - (43%)	Gaps:	48/307 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 SETDM----KRLQTILWLELATIFDRNKVSLDKRKPFKRRRKEEGNLFGVSINALIRRDQQVTGT 374
            |:.||    :.::.::|..|.....|:. .:...||.      ...:||..:...:..:::.
Mouse   155 SQRDMEDWVQAIRRVIWAPLGRGTSRSS-HVHPVKPL------SAGIFGQRLEDTVHHERKF--- 209

  Fly   375 DSSLVPLFLEKLIGELLRRGSREEGLLRIGGHKQKTELLYNELESTF--YQNPDNLDNLFRTAT- 436
            ...|.||.:|:.:..:..||..||||.|:.|...    |..:|:.:|  .:.|     ||.:.|
Mouse   210 GPRLAPLLVEQCVDFIRERGLSEEGLFRMPGQAN----LVRDLQDSFDCGEKP-----LFDSTTD 265

  Fly   437 VHELSSLLKRWLRELPQPLLTNELIQLFYQCHTLPSIDQMNA---LSILCHLLPPENRNTLRSLL 498
            ||.::||||.:|||||:|::.....:.|..|..|.:.|:...   |:.....||..|.|.||.:.
Mouse   266 VHTVASLLKLYLRELPEPVIPFARYEDFLSCAQLLTKDEGEGTVELAKQVSNLPQANYNLLRYIC 330

  Fly   499 SFFNIIINLKDINKMNVHNVATIMAPSMFPPRYIHP---SDNNSIAEQVRMAAQCCRLTNILILR 560
            .|.:.:....|:|||:|.|:||:..|::..|:...|   .:..|:.:         .|..:||.:
Mouse   331 KFLDEVQAHSDVNKMSVQNLATVFGPNILRPQIEDPVTIMEGTSLVQ---------HLMTVLIRK 386

  Fly   561 GEKLFQVPNNLIVESQKTMMGKKGWHRHRNSNEITAKPSGKASNVGV 607
            ..:||...:   :|...:..|...|    .|.|:|....|:..:.|:
Mouse   387 HGQLFAATS---LEEPASPHGTVEW----GSEEVTRDHRGEPGSPGL 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	63/228 (28%)
Arhgap22	XP_006519017.1	PH-like	62..177	CDD:388408	5/21 (24%)
		RhoGAP_ARHGAP22_24_25	193..391	CDD:239855	60/218 (28%)
		Macoilin	<529..>719	CDD:370635
		HCR	<638..719	CDD:284517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910