DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and Arhgap11a

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_852081.2	Gene:	Arhgap11a / 228482	MGIID:	2444300	Length:	987	Species:	Mus musculus

Alignment Length:	253	Identity:	61/253 - (24%)
Similarity:	108/253 - (42%)	Gaps:	43/253 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 RRRKE------EGNLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGEL----------LRRGSR 396
            |||.|      :|.:|||..|:|          ..|:||.|     |.:          |:....
Mouse    32 RRRHETAATEIKGKVFGVPFNSL----------PHSVVPEF-----GHIPSFLVDACASLKEHIH 81

  Fly   397 EEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNELI 461
            .|||.|..|...:.:.|.::|        |..:....:|...:::.|||::.||||:|:|..:|.
Mouse    82 TEGLFRKSGSVVRLKALKSKL--------DQGEACLSSALPCDVAGLLKQFFRELPEPVLPADLH 138

  Fly   462 QLFYQCHTLPSIDQMNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATIMAPSM 526
            :..::...|.:.::..|..:|..|:.....:.||...:|...:......|||:..|:|.|.||::
Mouse   139 EALFKAQQLGAEERNKATLLLSCLMANPTVDILRYFFNFLKSVSLRASENKMDSSNLAVIFAPNL 203

  Fly   527 FPPRYIHPSDNNSIAEQVRMAAQCCRLTNILILRGEKLFQVPNNLIVESQKTMMGKKG 584
            ......|...:.:..:::|:.|   .:....|.....:.:|| :.|:|....|:|..|
Mouse   204 LQTSEGHEKMSANTEKKLRLQA---AVVQTFIDCASDIGRVP-DFILEKIPAMLGIDG 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	53/229 (23%)
Arhgap11a	NP_852081.2	RhoGAP-ARHGAP11A	46..246	CDD:239859	51/226 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..341
		SH3-RhoG_link	371..>464	CDD:293215
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..669
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..756
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	960..987
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910