DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment conu and Arhgap29

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_001343453.1	Gene:	Arhgap29 / 214137	MGIID:	2443818	Length:	1266	Species:	Mus musculus

Alignment Length:	653	Identity:	131/653 - (20%)
Similarity:	241/653 - (36%)	Gaps:	177/653 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LNEYYLQSNSQSIEPEASYEDGEM-------------------EAEWLVSAGYPELTKPFEQGLE 64
            :.:.:.|..::.:|.|.:.:..::                   |.|.|.|:  ..|.|...:.||
Mouse   307 IKDLWKQQQNKLLETETALKKAKLLCMQRQDEYEKAKSSMFRAEEEQLSSS--VGLAKNLNKQLE 369

  Fly    65 VSKKDLEPILTTLSKPHAEAIVQLVRTLNKTVRVRTKSRPKRKPDIRDVFREFDEQGTVTRSR-- 127
             .::.||           |..:|.|...|:..:|...:..:|:.|:.:..||.     :|:.|
Mouse   370 -KRRRLE-----------EEALQKVEEANEHYKVCVTNVEERRNDLENTKREI-----LTQLRTL 417

  Fly   128 ---------SATPDSLDSLQIDEAWTNNSLPTF---VNVYEKNTETAIQCVEQSNEIYLKQNL-- 178
                     :.|.:.....|:..|...|||.:.   ..:|:...|.: :.|:.::...|::.:
Mouse   418 VFQCDLTLKAVTVNLFHMQQLQAASLANSLQSLCDSAKLYDPGQEYS-EFVKATSSSELEEKVDG 481

  Fly   179 ---RRTPSAPPKSG-----TYADIFR-------GSQVRCDIPLYSADGVELLGYSRIGTIQFPRN 228
               ::..::|..||     :..|:.|       ..:.||      ::..::.|.|.:.:.:|
Mouse   482 NVNKQMTNSPQTSGYEPADSLEDVARLPDSCHKLEEDRC------SNSADMTGPSFVRSWKF--- 537

  Fly   229 RSVSDPFCSIGRSKESRSENDARSQKKKSSEVLSASENECGRLLPMPYNVLSFESICRDSSSLDS 293
                        ...|.||:...|.:.:|.:..|.|..:..|.||.          ...|.::.|
Mouse   538 ------------GMFSDSESTGGSSESRSLDSESISPGDFHRKLPR----------TPSSGTMSS 580

  Fly   294 CEVLDTCDIPS--------------TLFTDVVLI-------SETDMKRLQTILWL------ELAT 331
            .:.||..:.||              ||.:...|.       |.|..:....|:..      |...
Mouse   581 ADDLDEREPPSPSEAGPNSLGAFKKTLMSKAALTHKFRKLRSPTKCRDCDGIVMFPGVECEECLL 645

  Fly   332 IFDRNKVSLDKRKPFKRRRKEEG--NLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLRRG 394
            :..|.  .|:........:|.:|  ::||...       .||...:...:|..|:....|:..|.
Mouse   646 VCHRK--CLENLVIICGHQKLQGKMHIFGAEF-------IQVAKKEPDGIPFVLKICASEIENRA 701

  Fly   395 SREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLTNE 459
            ...:|:.|:.|:|.|||.|...||     |..:|.::...:: |::..:||.:||:||:|.:...
Mouse   702 LCLQGIYRVCGNKIKTEKLCQALE-----NGMHLVDISEFSS-HDICDVLKLYLRQLPEPFILFR 760

  Fly   460 LIQLFYQC----------------------HTLPSIDQMNALSI----LCHLLPPENRNTLRSLL 498
            |.:.|...                      |...|| ::|.:.:    |...||..:.|:|..|:
Mouse   761 LYKEFIDLAKEIQHVNEEQEAKKDSPEDKKHPHVSI-EVNRILLKSKDLLRQLPASHFNSLHYLI 824

  Fly   499 SFFNIIINLKDINKMNVHNVATIMAPSMFPPR-YIHPSDNNSIAEQVRMAAQCCRLTNILILRGE 562
            :....:::..:.||||..|:..|..|::..|| ...|...:|:||....|    ||...||...:
Mouse   825 AHLRRVVDHAEENKMNSKNLGVIFGPTLIRPRPTTAPVTISSLAEYSNQA----RLVEFLITYSQ 885

  Fly   563 KLF 565
            |:|
Mouse   886 KIF 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	60/237 (25%)
Arhgap29	NP_001343453.1	BAR	220..436	CDD:325158	25/147 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..501		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..601		15/68 (22%)
		C1	614..659	CDD:197519	6/46 (13%)
		RhoGAP	671..883	CDD:295372	58/229 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1039..1081
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1116..1157
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1209..1266
		Interaction with PTPN13/PTPL1. /evidence=ECO:0000250	1263..1266
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910